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They are involved in the regulation of multiple signaling pathways implicated in cardiovascular diseases. Autophagy is a crucial adaptive cellular response to stress stimuli. Mounting evidence suggests a strong correlation between Sirtuins and autophagy, potentially involving cross-regulation and crosstalk. Sirtuin-mediated autophagy plays a crucial regulatory role in some cardiovascular diseases, including atherosclerosis, ischemia\/reperfusion injury, hypertension, heart failure, diabetic cardiomyopathy, and drug-induced myocardial damage. In this context, we summarize the research advancements pertaining to various Sirtuins involved in autophagy and the molecular mechanisms regulating autophagy. We also elucidate the biological function of Sirtuins across diverse cardiovascular diseases and further discuss the development of novel drugs that regulate Sirtuin-mediated autophagy.<\/jats:p>","DOI":"10.3390\/jcdd10090382","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:14:14Z","timestamp":1693995254000},"page":"382","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases"],"prefix":"10.3390","volume":"10","author":[{"given":"Yuqin","family":"Wang","sequence":"first","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongnan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical College, Lanzhou University, Lanzhou 730106, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxi","family":"Shen","sequence":"additional","affiliation":[{"name":"Qinghai Provincial People\u2019s Hospital, Qinghai University, Xining 810007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/genetics\/116.1.9","article-title":"Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae","volume":"116","author":"Rine","year":"1987","journal-title":"Genetics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41569-019-0235-9","article-title":"Lysine acetyltransferases and lysine deacetylases as targets for cardiovascular disease","volume":"17","author":"Li","year":"2020","journal-title":"Nat. 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