{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:27:27Z","timestamp":1785770847844,"version":"3.56.0"},"reference-count":64,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Women with hypertensive disorders of pregnancy (HDP) have a significantly higher risk of developing cardiovascular diseases later in life. The stratification of this risk using biomarkers during pregnancy can help to identify these women and apply early prevention. Objective: We aimed to determine proinflammatory cytokines and angiogenic markers, echocardiographic parameter changes after delivery and predict early cardiovascular disease risk in women with arterial hypertension and its complications during pregnancy. Methods: We conducted a literature search using the PubMed database for the last ten years. A total of 17 articles were included to our study and full text reviewed. Results: Four out of six studies found higher postpartum Interleukin-6 (IL-6) levels in women with HDP. IL\u20136 correlated positively with waist circumference, body mass index, and triglycerides, and negatively with high density lipoproteins (HDL). Two out of four studies found higher postpartum tumor necrosis factor alpha (TNF-\u03b1) levels in women with HDP but later concentration equalizes. One out of eight studies found higher placental growth factor (PlGF) and two out of eight found more elevated soluble fms-like tyrosine kinase-1 (sFlt-1) in women with HDP. With decreasing PlGF and increasing sFlt-1, common carotid artery intima and media thickness, aortic root diameter, left atrial diameter, left ventricle mass, systolic, diastolic, and mean blood pressure increased, whereas HDL decreased. One out of four studies found higher sFlt-1\/PlGF. Conclusion: IL-6 remains significantly higher after delivery. Few studies found higher TNF-\u03b1, sFlt-1, PlGF and their ratio postpartum. All studies found a correlation between angiogenic factors, IL-6, and cardiovascular disease risk factors.<\/jats:p>","DOI":"10.3390\/jcdd10100407","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T05:32:45Z","timestamp":1695360765000},"page":"407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Importance of Inflammatory and Angiogenic Markers in the Evaluation of Early Cardiovascular Disease Risk in Women with Hypertensive Disorders of Pregnancy"],"prefix":"10.3390","volume":"10","author":[{"given":"Tatjana","family":"Maselien\u0117","sequence":"first","affiliation":[{"name":"Clinics of Internal and Family Medicine, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilija","family":"Struckut\u0117","sequence":"additional","affiliation":[{"name":"Clinics of Obstetrics and Gyneacology, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u016bta","family":"Breivien\u0117","sequence":"additional","affiliation":[{"name":"Clinics of Obstetrics and Gyneacology, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1481-3558","authenticated-orcid":false,"given":"Diana","family":"Rama\u0161auskait\u0117","sequence":"additional","affiliation":[{"name":"Clinics of Obstetrics and Gyneacology, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1471-9131","authenticated-orcid":false,"given":"Vilma","family":"D\u017eenkevi\u010di\u016bt\u0117","sequence":"additional","affiliation":[{"name":"Clinics of Cardiology, Faculty of Medicine, Vilnius University, LT-01513 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccl.2020.09.005","article-title":"Hypertensive Disorders of Pregnancy","volume":"39","author":"Khedagi","year":"2021","journal-title":"Cardiol. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.bpobgyn.2011.01.006","article-title":"Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy","volume":"25","author":"Hutcheon","year":"2011","journal-title":"Best. Pract. Res. Clin. Obs. Gynaecol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: Pathophysiology, Challenges, and Perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-Eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11936-018-0653-8","article-title":"Hypertensive Disorders of Pregnancy and Cardiovascular Diseases: Current Knowledge and Future Directions","volume":"20","author":"Coutinho","year":"2018","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e003497","DOI":"10.1161\/CIRCOUTCOMES.116.003497","article-title":"Preeclampsia and Future Cardiovascular Health","volume":"10","author":"Wu","year":"2017","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/uog.22107","article-title":"Cardiovascular events following pregnancy complicated by pre-eclampsia with emphasis on comparison between early- and late-onset forms: Systematic review and meta-analysis","volume":"57","author":"Saccone","year":"2021","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e008337","DOI":"10.1161\/JAHA.117.008337","article-title":"Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women","volume":"7","author":"Riise","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1111\/1471-0528.15394","article-title":"Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: A systematic review and meta-analysis","volume":"125","author":"Brouwers","year":"2018","journal-title":"BJOG"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1089\/jwh.2018.7560","article-title":"Cardiovascular Disease-Related Pregnancy Complications Are Associated with Increased Maternal Levels and Trajectories of Cardiovascular Disease Biomarkers During and After Pregnancy","volume":"29","author":"Parikh","year":"2020","journal-title":"J. Womens Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1089\/jwh.2014.4811","article-title":"Cardiovascular Risk Factors One Year after a Hypertensive Disorder of Pregnancy","volume":"24","author":"Ehrenthal","year":"2015","journal-title":"J. Womens Health"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/hr.2013.81","article-title":"Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by preeclampsia","volume":"36","author":"Hamad","year":"2013","journal-title":"Hypertens. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.preghy.2018.06.019","article-title":"Postpartum evaluation of cardiovascular disease risk for women with pregnancies complicated by hypertension","volume":"13","author":"Escouto","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/heartjnl-2018-313453","article-title":"Future risk of cardiovascular disease risk factors and events in women after a hypertensive disorder of pregnancy","volume":"105","author":"Benschop","year":"2019","journal-title":"Heart"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/hr.2016.126","article-title":"Epidemiology of hypertensive disorders in pregnancy: Prevalence, risk factors, predictors and prognosis","volume":"40","author":"Umesawa","year":"2017","journal-title":"Hypertens. Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hong, K., Kim, S.H., Cha, D., and Park, H. (2021). Defective Uteroplacental Vascular Remodeling in Preeclampsia: Key Molecular Factors Leading to Long Term Cardiovascular Disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms222011202"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The role of inflammation in the pathology of preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/jch.13161","article-title":"Lipid profile and cytokines in hypertension of pregnancy: A comparison of preeclampsia therapies","volume":"20","author":"Wang","year":"2018","journal-title":"J. Clin. Hypertens."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S9.e1","DOI":"10.1016\/j.ajog.2015.08.003","article-title":"Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity","volume":"213","author":"Redman","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/HYPERTENSIONAHA.111.181735","article-title":"Angiogenic Factors in Superimposed Preeclampsia","volume":"59","author":"Perni","year":"2012","journal-title":"Hypertension"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/10641955.2020.1861462","article-title":"Soluble Flt1 levels are associated with cardiac dysfunction in Black women with and without severe preeclampsia","volume":"40","author":"Levine","year":"2021","journal-title":"Hypertens. Pregnancy"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"908649","DOI":"10.1155\/2010\/908649","article-title":"Maternal Serum Levels of TNF-Alpha and IL-6 Long after Delivery in Preeclamptic and Normotensive Pregnant Women","volume":"2010","author":"Vitoratos","year":"2010","journal-title":"Mediators Inflamm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/CIRCULATIONAHA.109.895458","article-title":"Prospective Study of Placental Angiogenic Factors and Maternal Vascular Function Before and After Preeclampsia and Gestational Hypertension","volume":"122","author":"Noori","year":"2010","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/uog.15981","article-title":"Association between angiogenic factors and signs of arterial aging in women with pre-eclampsia","volume":"50","author":"Akhter","year":"2017","journal-title":"Ultrasound Obs. Gynecol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/HYPERTENSIONAHA.111.172387","article-title":"Endothelial function and circulating biomarkers are disturbed in women and children after preeclampsia","volume":"58","author":"Kvehaugen","year":"2011","journal-title":"Hypertension"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Bokslag, A., Franssen, C., Alma, L.J., Kovacevic, I., van Kesteren, F., van Teunissen, P.W., Kamp, O., Ganzevoort, W., Hordijk, P.L., and de Groot, M. (2018). Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0198908"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Gaugler-Senden, I.P.M., Tamsma, J.T., van der Bent, C., Kusters, R., Steegers, E.A.P., and de Groot, C.J.M. (2012). Angiogenic factors in women ten years after severe very early onset preeclampsia. PLoS ONE., 7.","DOI":"10.1371\/journal.pone.0043637"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1161\/HYPERTENSIONAHA.120.15830","article-title":"Angiogenic Factors and Long-Term Cardiovascular Risk in Women That Developed Preeclampsia During Pregnancy","volume":"76","author":"Mendoza","year":"2020","journal-title":"Hypertension"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.preghy.2018.04.015","article-title":"Cardiovascular biomarkers in the years following pregnancies complicated by hypertensive disorders or delivered preterm","volume":"13","author":"Tanz","year":"2018","journal-title":"Pregnancy Hypertens."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1161\/01.HYP.0000143849.67254.ca","article-title":"Short- and Long-Term Changes in Plasma Inflammatory Markers Associated With Preeclampsia","volume":"44","author":"Freeman","year":"2004","journal-title":"Hypertension"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/NNR.0000000000000285","article-title":"Inflammatory Markers and Preeclampsia: A Systematic Review","volume":"67","author":"Black","year":"2018","journal-title":"Nurs. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12016-016-8596-x","article-title":"Tumor Necrosis Factor-Alpha and Pregnancy: Focus on Biologics. An Updated and Comprehensive Review","volume":"53","author":"Llurba","year":"2017","journal-title":"Clin. Rev. Allerg. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1093\/eurheartj\/ehv759","article-title":"Inflammatory cytokines in atherosclerosis: Current therapeutic approaches","volume":"37","author":"Tousoulis","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.placenta.2014.02.004","article-title":"Potentiating maternal immune tolerance in pregnancy: A new challenging role for regulatory T cells","volume":"35","author":"Llurba","year":"2014","journal-title":"Placenta"},{"key":"ref_35","first-page":"1205","article-title":"Tumor necrosis factor gene polymorphisms, leukocyte function, and sepsis susceptibility in blunt trauma patients","volume":"9","author":"Majetschak","year":"2002","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.jdiacomp.2016.05.011","article-title":"Altered cytokine network in gestational diabetes mellitus affects maternal insulin and placental-fetal development","volume":"30","author":"Wedekind","year":"2016","journal-title":"J. Diabetes Complicat."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1093\/humrep\/14.9.2386","article-title":"Pre-implantation endometrial leukocytes in women with recurrent miscarriage","volume":"14","author":"Quenby","year":"1999","journal-title":"Hum. Reprod."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11906-011-0224-9","article-title":"Immune mechanisms in hypertension","volume":"13","author":"Leibowitz","year":"2011","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.placenta.2009.11.005","article-title":"IL-6, TNF\u03b1 and TGF\u03b2 Promote Nonapoptotic Trophoblast Deportation and Subsequently Causes Endothelial Cell Activation","volume":"31","author":"Chen","year":"2010","journal-title":"Placenta"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.preghy.2020.12.001","article-title":"Cardiac dysfunction after preeclampsia; an overview of pro- and anti-fibrotic circulating effector molecules","volume":"23","author":"Mohseni","year":"2021","journal-title":"Pregnancy Hypertens."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.cyto.2014.12.024","article-title":"The varying faces of IL-6: From cardiac protection to cardiac failure","volume":"74","author":"Fontes","year":"2015","journal-title":"Cytokine"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1358863X20977662","article-title":"Expression of Interleukin 6 signaling receptors in carotid atherosclerosis","volume":"26","author":"Ziegler","year":"2021","journal-title":"Vasc. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1161\/HYPERTENSIONAHA.116.07252","article-title":"Circulating Antiangiogenic Factors and Myocardial Dysfunction in Hypertensive Disorders of Pregnancy","volume":"67","author":"Shahul","year":"2016","journal-title":"Hypertension"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1136\/heartjnl-2019-316215","article-title":"Global longitudinal strain: Clinical use and prognostic implications in contemporary practice","volume":"106","author":"Abou","year":"2020","journal-title":"Heart"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"A90","DOI":"10.1136\/heartjnl-2016-309890.128","article-title":"128 Abnormal Global Longitudinal Strain is Associated with All-Cause Mortality in Haemodialysis Patients","volume":"102","author":"Chiu","year":"2016","journal-title":"Heart"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.jacc.2011.02.005","article-title":"Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women\u20142011 Update: A Guideline From the American Heart Association","volume":"57","author":"Mosca","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.preghy.2020.11.011","article-title":"Angiogenic markers during preeclampsia: Are they associated with hypertension 1 year postpartum?","volume":"23","author":"Neuman","year":"2021","journal-title":"Pregnancy Hypertens."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/00365513.2016.1190863","article-title":"Sflt-1 in heart failure: Relation with disease severity and biomarkers","volume":"76","author":"Gruson","year":"2016","journal-title":"Scand. J. Clin. Lab. Investig."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.atherosclerosis.2022.02.026","article-title":"Soluble Fms-like tyrosine kinase-1 (sFlt-1) is associated with subclinical and clinical atherosclerotic cardiovascular disease: The Dallas Heart Study","volume":"346","author":"Mauricio","year":"2022","journal-title":"Atherosclerosis"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1253\/circj.CJ-18-0523","article-title":"Value of Placental Growth Factor as a Predictor of Adverse Events During the Acute Phase of Acute Decompensated Heart Failure","volume":"83","author":"Nakada","year":"2019","journal-title":"Circ. J."},{"key":"ref_51","unstructured":"(2022, July 03). Systematic Review and Meta-Analysis: Anti\u2013Tumor Necrosis Factor \u03b1 Therapy and Cardiovascular Events in Rheumatoid Arthritis. Available online: https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/acr.20371."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e005637","DOI":"10.1161\/JAHA.117.005637","article-title":"Interleukin-6 and the Risk of Adverse Outcomes in Patients After an Acute Coronary Syndrome: Observations From the SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib-Thrombolysis in Myocardial Infarction 52) Trial","volume":"6","author":"Fanola","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1681\/ASN.2014080772","article-title":"Placental Growth Factor as a Predictor of Cardiovascular Events in Patients with CKD from the NARA-CKD Study","volume":"26","author":"Matsui","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/jama.291.4.435","article-title":"Prognostic Value of Placental Growth Factor in Patients With Acute Chest Pain","volume":"291","author":"Heeschen","year":"2004","journal-title":"JAMA"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.cardfail.2014.05.013","article-title":"Biomarker predictors of cardiac hospitalization in chronic heart failure: A recurrent event analysis","volume":"20","author":"Vorovich","year":"2014","journal-title":"J. Card. Fail."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/uog.23745","article-title":"Peripartum echocardiographic changes in women with hypertensive disorders of pregnancy","volume":"59","author":"Giorgione","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"e018526","DOI":"10.1161\/JAHA.120.018526","article-title":"Long-Term Postpartum Cardiac Function and Its Association With Preeclampsia","volume":"10","author":"deMartelly","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/HYPERTENSIONAHA.113.01319","article-title":"Hypertension After Preeclampsia Is Preceded by Changes in Cardiac Structure and Function","volume":"62","author":"Peeters","year":"2013","journal-title":"Hypertension"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"S361","DOI":"10.1016\/j.ajog.2011.10.841","article-title":"823: Magnesium decreases inflammatory cytokine production: A novel innate immunomodulatory mechanism","volume":"206","author":"Bernstein","year":"2012","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.preghy.2012.04.007","article-title":"OS005. Treatment with magnesium sulphate reduced the serum level of IL-6in preeclamptic women","volume":"2","author":"Xiao","year":"2012","journal-title":"Pregnancy Hypertens."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cca.2012.05.007","article-title":"Serum interleukin-6 levels in response to methotrexate treatment in psoriatic patients","volume":"413","author":"Elango","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/eurheartj\/ehu272","article-title":"The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: The MRC-ILA Heart Study","volume":"36","author":"Morton","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1161\/CIRCULATIONAHA.112.122556","article-title":"Effects of Interleukin-1\u03b2 Inhibition with Canakinumab on Hemoglobin A1c, Lipids, C-Reactive Protein, Interleukin-6, and Fibrinogen","volume":"126","author":"Ridker","year":"2012","journal-title":"Circulation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1161\/HYPERTENSIONAHA.120.15875","article-title":"Postnatal Enalapril to Improve Cardiovascular Function Following Preterm Preeclampsia (PICk-UP)","volume":"76","author":"Ormesher","year":"2020","journal-title":"Hypertension"}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/10\/10\/407\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:55:45Z","timestamp":1760129745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/10\/10\/407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,22]]},"references-count":64,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2023,10]]}},"alternative-id":["jcdd10100407"],"URL":"https:\/\/doi.org\/10.3390\/jcdd10100407","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,22]]}}}