{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T02:31:20Z","timestamp":1792722680171,"version":"4.5.0"},"reference-count":69,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T00:00:00Z","timestamp":1697241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Cardiac resynchronization therapy (CRT) is a cornerstone therapeutic opportunity for selected patients with heart failure. For optimal patient selection, no other method has been proven to be more effective than the 12-lead ECG, and hence ECG characteristics are extensively researched. The evaluation of particular ECG signs before the implantation may improve selection and, consequently, clinical outcomes. The definition of a true left bundle branch block (LBBB) seems to be the best starting point with which to select patients for CRT. Although there are no universally accepted definitions of LBBB, using the classical LBBB criteria, some ECG parameters are associated with CRT response. In patients with non-true LBBB or non-LBBB, further ECG predictors of response and non-response could be analyzed, such as QRS fractionation, signs of residual left bundle branch conduction, S-waves in V6, intrinsicoid deflection, or non-invasive estimates of Q-LV which are described in newer publications. The most important and recent study results of the topic are summarized and discussed in this current review.<\/jats:p>","DOI":"10.3390\/jcdd10100425","type":"journal-article","created":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:59:59Z","timestamp":1697295599000},"page":"425","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Useful Electrocardiographic Signs to Support the Prediction of Favorable Response to Cardiac Resynchronization Therapy"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-6462","authenticated-orcid":false,"given":"Andras","family":"Simon","sequence":"first","affiliation":[{"name":"Department of Cardiology, Szent Imre University Teaching Hospital, 1115 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Pilecky","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"},{"name":"Doctoral School of Clinical Medicine, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-3552","authenticated-orcid":false,"given":"Loretta Zsuzsa","family":"Kiss","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-4443","authenticated-orcid":false,"given":"Mate","family":"Vamos","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology Division, Department of Internal Medicine, University of Szeged, 6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/S0735-1097(98)00492-6","article-title":"Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure","volume":"32","author":"Leclercq","year":"1998","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1056\/NEJMoa013168","article-title":"Cardiac Resynchronization in Chronic Heart Failure","volume":"346","author":"Abraham","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa032423","article-title":"Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure","volume":"350","author":"Bristow","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa0906431","article-title":"Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events","volume":"361","author":"Moss","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1056\/NEJMoa050496","article-title":"The Effect of Cardiac Resynchronization on Morbidity and Mortality in Heart Failure","volume":"352","author":"Cleland","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1056\/NEJMoa1009540","article-title":"Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure","volume":"363","author":"Tang","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.jacc.2008.08.027","article-title":"Randomized Trial of Cardiac Resynchronization in Mildly Symptomatic Heart Failure Patients and in Asymptomatic Patients with Left Ventricular Dysfunction and Previous Heart Failure Symptoms","volume":"52","author":"Linde","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","first-page":"e350","article-title":"ACC\/AHA\/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities","volume":"117","author":"Epstein","year":"2008","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.ejheart.2008.08.005","article-title":"ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2008","volume":"10","author":"Dickstein","year":"2008","journal-title":"Eur. J. Heart Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1306687","article-title":"Cardiac-Resynchronization Therapy in Heart Failure with a Narrow QRS Complex","volume":"369","author":"Ruschitzka","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1056\/NEJMoa0706695","article-title":"Cardiac-Resynchronization Therapy in Heart Failure with Narrow QRS Complexes","volume":"357","author":"Beshai","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIRCULATIONAHA.112.001239","article-title":"Cardiac Resynchronization Therapy in Patients with Heart Failure and a QRS Complex <120 Milliseconds","volume":"127","author":"Thibault","year":"2013","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1253\/circj.CJ-10-1268","article-title":"Non-Responders to Cardiac Resynchronization Therapy: The Magnitude of the Problem and the Issues","volume":"75","author":"Auricchio","year":"2011","journal-title":"Circ. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s10840-016-0180-z","article-title":"What is the cost of non-response to cardiac resynchronization therapy? Hospitalizations and healthcare utilization in the CRT-D population","volume":"47","author":"Corbisiero","year":"2016","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1001\/archinternmed.2011.247","article-title":"Impact of QRS Duration on Clinical Event Reduction with Cardiac Resynchronization Therapy: Meta-analysis of Randomized Controlled Trials","volume":"171","author":"Sipahi","year":"2011","journal-title":"Arch. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.amjcard.2008.08.069","article-title":"Usefulness of baseline electrocardiographic QRS complex pattern to predict response to cardiac resynchronization","volume":"103","author":"Adelstein","year":"2009","journal-title":"Am. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.hrthm.2009.07.009","article-title":"Upgrade and de novo cardiac resynchronization therapy: Impact of paced or intrinsic QRS morphology on outcomes and survival","volume":"6","author":"Wokhlu","year":"2009","journal-title":"Heart Rhythm"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1161\/CIRCULATIONAHA.110.960898","article-title":"Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial- Cardiac Resynchronization Therapy (MADIT-CRT)","volume":"123","author":"Zareba","year":"2011","journal-title":"Circulation"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/CIRCEP.113.001299","article-title":"PR interval identifies clinical response in patients with non-left bundle branch block: A Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy substudy","volume":"7","author":"Kutyifa","year":"2014","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jacc.2012.07.009","article-title":"2012 ACCF\/AHA\/HRS Focused Update of the 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: A Report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"60","author":"Tracy","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy: Developed by the Task Force on cardiac pacing and cardiac resynchronization therapy of the European Society of Cardiology (ESC) With the special contribution of the European Heart Rhythm Association (EHRA)","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/CIRCULATIONAHA.112.097709","article-title":"Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: Results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study","volume":"126","author":"Gold","year":"2012","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.amjcard.2010.11.010","article-title":"Defining Left Bundle Branch Block in the Era of Cardiac Resynchronization Therapy","volume":"107","author":"Strauss","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/S0735-1097(85)80335-1","article-title":"Criteria for intraventricular conduction disturbances and pre-excitation","volume":"5","author":"Willems","year":"1985","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1540-8167.2009.01714.x","article-title":"The Surface Electrocardiogram Predicts Risk of Heart Block During Right Heart Catheterization in Patients with Preexisting Left Bundle Branch Block: Implications for the Definition of Complete Left Bundle Branch Block","volume":"21","author":"Padanilam","year":"2010","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jacc.2008.04.036","article-title":"Predicting the Long-Term Effects of Cardiac Resynchronization Therapy on Mortality from Baseline Variables and the Early Response: A Report From the CARE-HF (Cardiac Resynchronization in Heart Failure) Trial","volume":"52","author":"Cleland","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1161\/CIRCULATIONAHA.110.014324","article-title":"Predictors of Response to Cardiac Resynchronization Therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT)","volume":"124","author":"Goldenberg","year":"2011","journal-title":"Circulation"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jacep.2019.10.009","article-title":"Evaluating Electrocardiography-Based Identification of Cardiac Resynchronization Therapy Responders Beyond Current Left Bundle Branch Block Definitions","volume":"6","author":"Hoogland","year":"2020","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1540-8159.2012.03427.x","article-title":"Electrocardiographic Criteria of True Left Bundle Branch Block: A Simple Sign to Predict a Better Clinical and Instrumental Response to CRT","volume":"35","author":"Mascioli","year":"2012","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1093\/europace\/eut049","article-title":"True complete left bundle branch block morphology strongly predicts good response to cardiac resynchronization therapy","volume":"15","author":"Tian","year":"2013","journal-title":"EP Europace"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10840-018-0363-x","article-title":"Cardiac resynchronization therapy response in heart failure patients with different subtypes of true left bundle branch block","volume":"52","author":"Kreidieh","year":"2018","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1093\/europace\/eur381","article-title":"Greater response to cardiac resynchronization therapy in patients with true complete left bundle branch block: A PREDICT substudy","volume":"14","author":"Perrin","year":"2011","journal-title":"EP Europace"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/clc.22061","article-title":"Number of Leads with Fragmented QRS Predicts Response to Cardiac Resynchronization Therapy","volume":"36","author":"Celikyurt","year":"2013","journal-title":"Clin. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.rce.2018.11.008","article-title":"El inicio r\u00e1pido de la fragmentaci\u00f3n del QRS predice la no respuesta a la terapia de resincronizaci\u00f3n card\u00edaca en pacientes con insuficiencia card\u00edaca no isqu\u00e9mica","volume":"219","author":"Celikyurt","year":"2019","journal-title":"Rev. Cl\u00ednica Espa\u00f1ola"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1542-474X.2011.00424.x","article-title":"QRS fragmentation is not associated with poor response to cardiac resynchronization therapy","volume":"16","author":"Rickard","year":"2011","journal-title":"Ann. Noninvasive Electrocardiol. Off. J. Int. Soc. Holter Noninvasive Electrocardiol. Inc"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/europace\/eut151","article-title":"A novel electrocardiographic predictor of clinical response to cardiac resynchronization therapy","volume":"15","author":"Mollo","year":"2013","journal-title":"EP Europace"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1161\/CIRCEP.108.798660","article-title":"ECG Quantification of Myocardial Scar in Cardiomyopathy Patients with or Without Conduction Defects","volume":"1","author":"Strauss","year":"2008","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.hrthm.2019.09.007","article-title":"An S wave in ECG lead V6 predicts poor response to cardiac resynchronization therapy and long-term outcome","volume":"17","author":"Jiang","year":"2020","journal-title":"Heart Rhythm"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccep.2018.02.003","article-title":"Intraventricular Delay and Blocks","volume":"10","author":"Leonelli","year":"2018","journal-title":"Card. Electrophysiol. Clin."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"iv4","DOI":"10.1093\/europace\/euw346","article-title":"Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions","volume":"18","author":"Zemzemi","year":"2016","journal-title":"EP Europace"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3889\/oamjms.2018.092","article-title":"Electrocardiographic Parameters as Predictors of Response to Cardiac Resynchronization Therapy","volume":"6","author":"Poposka","year":"2018","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/jce.13875","article-title":"Low lead one ratio predicts clinical outcomes in left bundle branch block","volume":"30","author":"Loring","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jce.12057","article-title":"QRS Axis and the Benefit of Cardiac Resynchronization Therapy in Patients with Mildly Symptomatic Heart Failure Enrolled in MADIT-CRT","volume":"24","author":"Brenyo","year":"2013","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jelectrocard.2019.04.007","article-title":"Left axis deviation in patients with left bundle branch block is a marker of myocardial disease associated with poor response to cardiac resynchronization therapy","volume":"63","author":"Hansen","year":"2020","journal-title":"J. Electrocardiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/jce.12887","article-title":"Prognostic Impact of QRS Axis Deviation in Patients Treated with Cardiac Resynchronization Therapy","volume":"27","author":"Perrotta","year":"2016","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.hrthm.2013.03.045","article-title":"Delayed intrinsicoid deflection onset in surface ECG lateral leads predicts left ventricular reverse remodeling after cardiac resynchronization therapy","volume":"10","author":"Powell","year":"2013","journal-title":"Heart Rhythm"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/europace\/euw326","article-title":"Novel electrocardiographic dyssynchrony criteria improve patient selection for cardiac resynchronization therapy","volume":"20","author":"Vereckei","year":"2016","journal-title":"EP Europace"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.hrthm.2006.07.034","article-title":"Left ventricular lead electrical delay predicts response to cardiac resynchronization therapy","volume":"3","author":"Singh","year":"2006","journal-title":"Heart Rhythm"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1093\/eurheartj\/ehr329","article-title":"The relationship between ventricular electrical delay and left ventricular remodelling with cardiac resynchronization therapy","volume":"32","author":"Gold","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.hrthm.2016.07.010","article-title":"ECG parameters predict left ventricular conduction delay in patients with left ventricular dysfunction","volume":"13","author":"Pastore","year":"2016","journal-title":"Heart Rhythm"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/01.CIR.17.3.397","article-title":"The Concept of \u201cMasquerading\u201d Bundle-Branch Block","volume":"17","author":"Unger","year":"1958","journal-title":"Circulation"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0002-8703(54)90295-1","article-title":"Left bundle branch block masquerading as right bundle branch block","volume":"47","author":"Richman","year":"1954","journal-title":"Am. Heart J."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1586\/erc.12.142","article-title":"Masquerading bundle branch block: A variety of right bundle branch block with left anterior fascicular block","volume":"11","author":"Elizari","year":"2013","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/CIRCEP.113.000999","article-title":"Electrocardiographic Features and Prevalence of Bilateral Bundle-Branch Delay","volume":"7","author":"Tzogias","year":"2014","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1093\/europace\/eux362","article-title":"Patients with right bundle branch block and concomitant delayed left ventricular activation respond to cardiac resynchronization therapy","volume":"20","author":"Pastore","year":"2017","journal-title":"EP Europace"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jelectrocard.2015.12.001","article-title":"Evaluation of R-wave offset in the left chest leads for estimating the left ventricular activation delay: An evaluation based on coronary sinus electrograms and the 12-lead electrocardiogram","volume":"49","author":"Hara","year":"2016","journal-title":"J. Electrocardiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s10840-019-00671-3","article-title":"The QR-max index, a novel electrocardiographic index for the determination of left ventricular conduction delay and selection of cardiac resynchronization in patients with non-left bundle branch block","volume":"58","author":"Pastore","year":"2020","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"2571","DOI":"10.1001\/jama.2009.888","article-title":"Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block","volume":"301","author":"Cheng","year":"2009","journal-title":"JAMA"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/jce.13131","article-title":"Effect of PR Interval on Outcomes Following Cardiac Resynchronization Therapy: A Secondary Analysis of the COMPANION Trial","volume":"28","author":"Lin","year":"2017","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/pace.13802","article-title":"PR Prolongation predicts inadequate resynchronization with biventricular pacing in left bundle branch block","volume":"42","author":"Atwater","year":"2019","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/anec.12313","article-title":"Different Methods to Measure QRS Duration in CRT Patients: Impact on the Predictive Value of QRS Duration Parameters","volume":"21","author":"Timmers","year":"2016","journal-title":"Ann. Noninvasive Electrocardiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijcard.2019.01.051","article-title":"Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy","volume":"286","author":"Vanbelle","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jelectrocard.2014.10.003","article-title":"Vectorcardiographic QRS area as a novel predictor of response to cardiac resynchronization therapy","volume":"48","author":"Vernooy","year":"2015","journal-title":"J. Electrocardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/europace\/euw445","article-title":"Refining success of cardiac resynchronization therapy using a simple score predicting the amount of reverse ventricular remodelling: Results from the Markers and Response to CRT (MARC) study","volume":"20","author":"Maass","year":"2017","journal-title":"EP Europace"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.hrthm.2018.08.028","article-title":"Vectorcardiographic QRS area is associated with long-term outcome after cardiac resynchronization therapy","volume":"16","author":"Emerek","year":"2019","journal-title":"Heart Rhythm"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.jelectrocard.2015.05.004","article-title":"An in-silico analysis of the effect of heart position and orientation on the ECG morphology and vectorcardiogram parameters in patients with heart failure and intraventricular conduction defects","volume":"48","author":"Potse","year":"2015","journal-title":"J. Electrocardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/jce.14299","article-title":"Novel ultra-high-frequency electrocardiogram tool for the description of the ventricular depolarization pattern before and during cardiac resynchronization","volume":"31","author":"Jurak","year":"2020","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e008210","DOI":"10.1161\/CIRCEP.119.008210","article-title":"Machine Learning of 12-Lead QRS Waveforms to Identify Cardiac Resynchronization Therapy Patients with Differential Outcomes","volume":"13","author":"Feeny","year":"2020","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1177882","DOI":"10.3389\/fcvm.2023.1177882","article-title":"Editorial: Developments in cardiac implantable electronic device therapy: How can we improve clinical implementation?","volume":"10","author":"Vamos","year":"2023","journal-title":"Front. Cardiovasc. 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