{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T20:45:53Z","timestamp":1775076353872,"version":"3.50.1"},"reference-count":26,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Pujiang Talents Plan","award":["SKW1818"],"award-info":[{"award-number":["SKW1818"]}]},{"name":"Pujiang Talents Plan","award":["GJ1830"],"award-info":[{"award-number":["GJ1830"]}]},{"name":"National Natural Science Foundation of China","award":["SKW1818"],"award-info":[{"award-number":["SKW1818"]}]},{"name":"National Natural Science Foundation of China","award":["GJ1830"],"award-info":[{"award-number":["GJ1830"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Integrin \u03b2 plays an important role in the pathogenesis of thrombosis and inflammation, and it may be a shared pathogenic mechanism between arterial and venous thromboses. With the goal of identifying new treatment targets for thrombotic diseases and specific diagnostic markers for venous thromboembolism (VTE), this prospective clinical study was performed to clarify the relationship between integrin and thrombosis. The levels of integrin \u03b21\u20133, interleukin-6 (IL-6), and C-reactive protein were significantly higher in patients with acute myocardial infarction (AMI; n = 44) and acute VTE (n = 43) compared to healthy controls (n = 33). The IL-6 and integrin \u03b21\u20133 levels were also significantly higher in the AMI group compared to the VTE and control groups. Logistic regression analysis identified IL-6 and integrin \u03b21\u20133 levels as independent risk factors for thrombotic disease. Based on the receiver-operating characteristic curve, Youden index, sensitivity, and specificity, the diagnostic accuracy value for VTE was greater than 0.8 when integrins \u03b21, \u03b22, and \u03b23 were combined. Overall, these results suggest that integrin \u03b2 levels can contribute to improving the diagnosis and treatment of arteriovenous thrombosis.<\/jats:p>","DOI":"10.3390\/jcdd10110461","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T10:57:46Z","timestamp":1700045866000},"page":"461","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrin \u03b2 Expression as a New Diagnostic Marker for Arteriovenous Thrombosis: A Single-Center Prospective Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Yan","family":"Xi","sequence":"first","affiliation":[{"name":"Department of General Practice, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Practice, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Emergency Internal Medicine, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xudong","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1161\/CIRCULATIONAHA.104.521344","article-title":"High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men","volume":"112","author":"Deguchi","year":"2005","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa022157","article-title":"An association between atherosclerosis and venous thrombosis","volume":"348","author":"Prandoni","year":"2003","journal-title":"N. 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