{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:09:27Z","timestamp":1793322567074,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"French Government as part of the \u201cInvestments of the future\u201d program managed by the National Research Agency","award":["ANR-16-IDEX-0007"],"award-info":[{"award-number":["ANR-16-IDEX-0007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Persistent patent ductus arteriosus is a very common condition in preterm infants. Although there is no management agreed by consensus, despite numerous randomized controlled trials, hemodynamically significant patent ductus arteriosus increases morbidity and mortality in these vulnerable patients. Medical treatment is usually offered as first-line therapy, although it carries a limited success rate and potential severe adverse events. In recent years, transcatheter patent ductus arteriosus closure has fast developed and become widely accepted as a safe and efficient alternative to surgical ductal ligation in extremely low birth weight infants &gt;700 g, using most often the dedicated Amplatzer Piccolo Occluder device. This article aims to provide an appraisal of the patients\u2019 selection process, and a step-by-step description of the procedure as well as a comprehensive review of its outcomes.<\/jats:p>","DOI":"10.3390\/jcdd10120476","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T03:35:06Z","timestamp":1701056106000},"page":"476","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Transcatheter Closure of Patent Ductus Arteriosus in Extremely Low-Birth-Weight Infants: Technique and Results"],"prefix":"10.3390","volume":"10","author":[{"given":"Alban-Elouen","family":"Baruteau","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology and Pediatric Cardiac Surgery, CHU Nantes, Nantes Universit\u00e9, FHU PRECICARE, F-44000 Nantes, France"},{"name":"CIC FEA 1413, INSERM, CHU Nantes, Nantes Universit\u00e9, F-44000 Nantes, France"},{"name":"L\u2019institut du thorax, INSERM, CNRS, CHU Nantes, Nantes Universit\u00e9, F-44000 Nantes, France"},{"name":"UMR 1280, PhAN, INRAE, Nantes Universit\u00e9, F-44000 Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Fraisse","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Services, Royal Brompton Hospital, Guy\u2019s & St Thomas\u2019 Foundation Trust, London SW3 6NP, UK"},{"name":"National Heart and Lung Institute, Imperial College, London SW7 2BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1288-0108","authenticated-orcid":false,"given":"Gianfranco","family":"Butera","sequence":"additional","affiliation":[{"name":"Cardiology, Cardiac Surgery and Heart Lung Transplantation, ERN GUARD HEART: Bambino Ges\u00f9 Hospital and Research Institute, IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carles","family":"Bautista-Rodriguez","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Services, Royal Brompton Hospital, Guy\u2019s & St Thomas\u2019 Foundation Trust, London SW3 6NP, UK"},{"name":"National Heart and Lung Institute, Imperial College, London SW7 2BX, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"F424","DOI":"10.1136\/adc.2007.118117","article-title":"Towards rational management of the patent ductus arteriosus: The need for disease staging","volume":"92","author":"McNamara","year":"2007","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1056\/NEJMoa2207418","article-title":"Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus","volume":"388","author":"Hundscheid","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e20201209","DOI":"10.1542\/peds.2020-1209","article-title":"Patent Ductus Arteriosus of the Preterm Infant","volume":"146","author":"Hamrick","year":"2020","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1007\/s00246-021-02665-3","article-title":"Consensus Guidelines for the Prevention and Management of Periprocedural Complications of Transcatheter Patent Ductus Arteriosus Closure with the Amplatzer Piccolo Occluder in Extremely Low Birth Weight Infants","volume":"42","author":"Sathanandam","year":"2021","journal-title":"Pediatr. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/ccd.27091","article-title":"Transcatheter closure of hemodynamic significant patent ductus arteriosus in 32 premature infants by amplatzer ductal occluder additional size-ADOIIAS","volume":"90","author":"Morville","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s00246-017-1768-5","article-title":"Surgical Ligation Versus Percutaneous Closure of Patent Ductus Arteriosus in Very Low-Weight Preterm Infants: Which are the Real Benefits of the Percutaneous Approach?","volume":"39","year":"2018","journal-title":"Pediatr. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijcard.2017.10.020","article-title":"Patent Ductus Arteriosus closure in preterms less than 2 kg: Surgery versus transcatheter","volume":"250","author":"Pamukcu","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijcard.2020.03.040","article-title":"Improved ventilation in premature babies after transcatheter versus surgical closure of patent ductus arteriosus","volume":"311","author":"Regan","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ccd.28502","article-title":"Percutaneous closure of patent ductus arteriosus in premature infants: A French national survey","volume":"95","author":"Akhavi","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1002\/ccd.28973","article-title":"Amplatzer Piccolo Occluder clinical trial for percutaneous closure of the patent ductus arteriosus in patients \u2265700 grams","volume":"96","author":"Sathanandam","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"615919","DOI":"10.3389\/fped.2020.615919","article-title":"Transcatheter Closure of Patent Ductus Arteriosus in Premature Infants with Very Low Birth Weight","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_12","first-page":"455","article-title":"Global birth prevalence of congenital heart defects 1970\u20132017: Updated systematic review and meta-analysis of 260 studies","volume":"48","author":"Liu","year":"2019","journal-title":"Leuk. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"558256","DOI":"10.3389\/fped.2020.558256","article-title":"Transcatheter Closure of Patent Ductus Arteriosus in Infants with Weight under 1500 Grams","volume":"8","author":"Fraisse","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e20164258","DOI":"10.1542\/peds.2016-4258","article-title":"Spontaneous Closure of Patent Ductus Arteriosus in Infants \u22641500 g","volume":"140","author":"Semberova","year":"2017","journal-title":"Pediatrics"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"573627","DOI":"10.3389\/fped.2020.573627","article-title":"Echocardiographic Diagnosis and Hemodynamic Evaluation of Patent Ductus Arteriosus in Extremely Low Gestational Age Newborn (ELGAN) Infants","volume":"8","author":"Singh","year":"2020","journal-title":"Front. Pediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"F248","DOI":"10.1136\/adc.2005.078600","article-title":"Catheter closure of the arterial duct in preterm infants","volume":"92","author":"Roberts","year":"2007","journal-title":"Arch. Dis. Child.-Fetal Neonatal Ed."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ccd.25534","article-title":"A novel technique for transcatheter patent ductus arteriosus closure in extremely preterm infants using commercially available technology","volume":"85","author":"Zahn","year":"2015","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.jcin.2016.09.019","article-title":"Transcatheter Closure of Patent Ductus Arteriosus in Extremely Premature Newborns: Early Results and Midterm Follow-Up","volume":"9","author":"Zahn","year":"2016","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ccd.26287","article-title":"Morphologic characterization of the patent ductus arteriosus in the premature infant and the choice of transcatheter occlusion device","volume":"87","author":"Philip","year":"2016","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ccd.27808","article-title":"Role of Transcatheter patent ductus arteriosus closure in extremely low birth weight infants","volume":"93","author":"Sathanandam","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ccd.22657","article-title":"Transcatheter closure of a patent ductus arteriosus in a preterm infant with an Amplatzer Vascular Plug IV device","volume":"77","author":"Prsa","year":"2011","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/ccd.26878","article-title":"Initial clinical experience with the Medtronic Micro Vascular Plug\u2122 in transcatheter occlusion of PDAs in extremely premature infants","volume":"89","author":"Sathanandam","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/ccd.29298","article-title":"Early experience with the Micro Plug Set for preterm patent ductus arteriosus closure","volume":"96","author":"Heyden","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1007\/s00246-022-02903-2","article-title":"Institutional Trend in Device Selection for Transcatheter PDA Closure in Premature Infants","volume":"43","author":"Guyon","year":"2022","journal-title":"Pediatr. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e025343","DOI":"10.1161\/JAHA.122.025343","article-title":"Feasibility, Safety, and Short-Term Outcomes of Transcatheter Patent Ductus Arteriosus Closure in Premature Infants on High-Frequency Jet Ventilation","volume":"11","author":"Shibbani","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1017\/S1047951121004601","article-title":"Transjugular venous approach for Piccolo patent ductus arteriosus closure in a 1.4 kg infant","volume":"32","author":"Herron","year":"2022","journal-title":"Cardiol. Young"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/chd.12700","article-title":"Can transcatheter PDA closure be performed in neonates \u22641000 grams? The Memphis experience","volume":"14","author":"Sathanandam","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.acvd.2021.06.002","article-title":"Transcatheter patent arterial duct closure in premature infants: A new technique to ease access to the patent arterial duct, with particular benefit for the tricuspid valve","volume":"114","author":"Meot","year":"2021","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ijcard.2020.04.057","article-title":"Transcatheter patent ductus arteriosus closure in preterm infants: Appropriate device selection is primordial","volume":"316","author":"Baruteau","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1017\/S1047951123000938","article-title":"Late aortic obstruction due to ductal vasoconstriction on pulmonic end after transcatheter patent ductus arteriosus closure in an extremely low-birth-weight infant","volume":"33","author":"Padovani","year":"2023","journal-title":"Cardiol. Young"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s41372-019-0513-8","article-title":"Comparison of \u2018post-patent ductus arteriosus ligation syndrome\u2019 in premature infants after surgical ligation vs. percutaneous closure","volume":"40","author":"Serrano","year":"2020","journal-title":"J. Perinatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1055\/s-0039-1698459","article-title":"Short-Term Complications Associated with Surgical Ligation of Patent Ductus Arteriosus in ELBW Infants: A 25-Year Cohort Study","volume":"38","author":"Foster","year":"2021","journal-title":"Am. J. Perinatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s41372-018-0056-4","article-title":"Post-ligation cardiac syndrome is associated with increased morbidity in preterm infants","volume":"38","author":"Ulrich","year":"2018","journal-title":"J. Perinatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s00246-018-1967-8","article-title":"Incidence, Risk Factors, and Comorbidities of Vocal Cord Paralysis after Surgical Closure of a Patent Ductus Arteriosus: A Meta-analysis","volume":"40","author":"Henry","year":"2019","journal-title":"Pediatr. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s00246-020-02523-8","article-title":"Fate of the Left Pulmonary Artery and Thoracic Aorta after Transcatheter Patent Ductus Arteriosus Closure in Low Birth Weight Premature Infants","volume":"42","author":"Markush","year":"2021","journal-title":"Pediatr. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41372-023-01741-1","article-title":"3-year follow-up of a prospective, multicenter study of the Amplatzer Piccolo\u2122 Occluder for transcatheter patent ductus arteriosus closure in children \u2265700 g","volume":"43","author":"Morray","year":"2023","journal-title":"J. Perinatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e048576","DOI":"10.1136\/bmjopen-2020-048576","article-title":"Exposure to low-dose ionising radiation from cardiac catheterisation and risk of cancer: The COCCINELLE study cohort profile","volume":"11","author":"Abalo","year":"2021","journal-title":"BMJ Open"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1159\/000512110","article-title":"Hypothyroidism after Percutaneous Patent Ductus Arteriosus Device Closure in an Extremely Preterm Infant: Possible Role of Iodinated IV Contrast","volume":"117","author":"Piatek","year":"2020","journal-title":"Neonatology"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ccd.22637","article-title":"Echocardiographically guided catheter closure of arterial ducts in small preterm infants on the neonatal intensive care unit","volume":"77","author":"Bentham","year":"2011","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_40","first-page":"4716997","article-title":"Bedside Transcatheter Patent Ductus Arteriosus Device Occlusion in an Extremely Low Birth Weight Neonate: A Novel Approach in a High-Risk Population","volume":"2021","author":"Pouldar","year":"2021","journal-title":"Case Rep. Anesthesiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.jcin.2021.01.009","article-title":"Transvenous, Echocardiographically Guided Closure of Persistent Ductus Arteriosus in 11 Premature Infants: A Pilot Study","volume":"14","author":"Georgiev","year":"2021","journal-title":"JACC Cardiovasc. Interv."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/10\/12\/476\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:31:02Z","timestamp":1760131862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/10\/12\/476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":41,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2023,12]]}},"alternative-id":["jcdd10120476"],"URL":"https:\/\/doi.org\/10.3390\/jcdd10120476","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]}}}