{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:30:52Z","timestamp":1782397852371,"version":"3.54.5"},"reference-count":85,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["491183248"],"award-info":[{"award-number":["491183248"]}]},{"name":"Open Access Publishing Fund of the University of Bayreuth","award":["491183248"],"award-info":[{"award-number":["491183248"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The coronavirus disease (COVID)-19 has turned into a pandemic causing a global public health crisis. While acute COVID-19 mainly affects the respiratory system and can cause acute respiratory distress syndrome, an association with persistent inflammatory stress affecting different organ systems has been elucidated in long COVID syndrome (LCS). Increased severity and mortality rates have been reported due to cardiophysiological and metabolic systemic disorders as well as multiorgan failure in COVID-19, additionally accompanied by chronic dyspnea and fatigue in LCS. Hence, novel therapies have been tested to improve the outcomes of LCS of which one potential candidate might be sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors. The aim of this narrative review was to discuss rationales for investigating SGLT2 inhibitor therapy in people suffering from LCS. In this regard, we discuss their potential positive effects\u2014next to the well described \u201ccardio-renal-metabolic\u201d conditions\u2014with a focus on potential anti-inflammatory and beneficial systemic effects in LCS. However, potential beneficial as well as potential disadvantageous effects of SGLT2 inhibitors on the prevalence and long-term outcomes of COVID-19 will need to be established in ongoing research.<\/jats:p>","DOI":"10.3390\/jcdd10120478","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T03:53:52Z","timestamp":1701230032000},"page":"478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["SGLT2 Inhibitors in Long COVID Syndrome: Is There a Potential Role?"],"prefix":"10.3390","volume":"10","author":[{"given":"Paul","family":"Zimmermann","sequence":"first","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"},{"name":"Interdisciplinary Center of Sportsmedicine Bamberg, Klinikum Bamberg, 96049 Bamberg, Germany"},{"name":"Department of Cardiology, Klinikum Bamberg, 96049 Bamberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3510-9594","authenticated-orcid":false,"given":"Harald","family":"Sourij","sequence":"additional","affiliation":[{"name":"Interdisciplinary Metabolic Medicine Research Group, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-1413","authenticated-orcid":false,"given":"Felix","family":"Aberer","sequence":"additional","affiliation":[{"name":"Interdisciplinary Metabolic Medicine Research Group, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Rilstone","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"},{"name":"Faculty of Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7761-9261","authenticated-orcid":false,"given":"Janis","family":"Schierbauer","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Othmar","family":"Moser","sequence":"additional","affiliation":[{"name":"Division of Exercise Physiology and Metabolism, BaySpo\u2014Bayreuth Center of Sport Science, University of Bayreuth, 95440 Bayreuth, Germany"},{"name":"Interdisciplinary Metabolic Medicine Research Group, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/jdi.13326","article-title":"Dissecting the Interaction between COVID-19 and Diabetes Mellitus","volume":"11","author":"Chee","year":"2020","journal-title":"J. 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