{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:35:00Z","timestamp":1760142900984,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,6]],"date-time":"2024-01-06T00:00:00Z","timestamp":1704499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Surgical repair for regurgitant bicuspid aortic valve (BAV) is promising but underutilized due to perceived complexities and lack of long-term data. This study evaluated the efficacy of valve-sparing root remodeling (VSRR) or isolated valve repair combined with calibrated external ring annuloplasty in BAV versus tricuspid aortic valve (TAV) patients. All patients operated on for aortic regurgitation and\/or aneurysm at our institution between 2014 and 2022 were included and entered into the Aortic Valve Insufficiency and ascending aorta Aneurysm InternATiOnal Registry (AVIATOR). Patients with successful repair at index surgery (100% in the BAV group, 93% in the TAV group, p = 0.044) were included in a systemic follow-up with echocardiography at regular intervals. Among 132 patients, 58 were in the BAV (44%) and 74 in the TAV group (56%). There were no inter-group differences in preoperative patient characteristics, except BAV patients being significantly younger (47 \u00b1 18 y vs. 60 \u00b1 14 y, p &lt; 0.001) and having narrower aortic roots at the level of sinuses (41 \u00b1 6 mm vs. 46 \u00b1 13 mm, p &lt; 0.001) and sinotubular junctions (39 \u00b1 10 mm vs. 42 \u00b1 11, p = 0.032). No perioperative deaths were recorded. At four years, there was no significant difference in terms of overall survival (96.3% BAV vs. 97.2% TAV, p = 0.373), freedom from valve reintervention (85.2% BAV vs. 93.4% TAV, p = 0.905), and freedom from severe aortic regurgitation (94.1% BAV vs. 82.9% TAV, p = 0.222). Surgical repair of BAV combined with extra-aortic annuloplasty can be performed with low perioperative morbidity and mortality and excellent mid-term results which are comparable to TAV repair.<\/jats:p>","DOI":"10.3390\/jcdd11010017","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T03:49:04Z","timestamp":1704685744000},"page":"17","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aortic Valve Repair with External Annuloplasty in Bicuspid versus Tricuspid Aortic Valve Patients"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5955-0275","authenticated-orcid":false,"given":"Davor","family":"Baric","sequence":"first","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Sliskovic","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Sestan","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savica","family":"Gjorgjievska","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Unic","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Kusurin","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josip","family":"Varvodic","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8580-2357","authenticated-orcid":false,"given":"Zrinka","family":"Safaric Oremus","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Reanimatology and Intensive Care Medicine, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana","family":"Jurin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikola","family":"Bulj","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Centre \u201cSestre Milosrdnice\u201d, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dubravka","family":"Susnjar","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7735-6721","authenticated-orcid":false,"given":"Igor","family":"Rudez","sequence":"additional","affiliation":[{"name":"Department of Cardiac and Transplant Surgery, Dubrava University Hospital, 10 000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1161\/01.CIR.0000027905.26586.E8","article-title":"Clinical and pathophysiological implications of a bicuspid aortic valve","volume":"106","author":"Fedak","year":"2002","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/jocs.12382","article-title":"Valve cuspidity: A risk factor for aortic valve repair?","volume":"29","author":"Holubec","year":"2014","journal-title":"J. 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Surg."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/1\/17\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:41:15Z","timestamp":1760103675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/1\/17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,6]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["jcdd11010017"],"URL":"https:\/\/doi.org\/10.3390\/jcdd11010017","relation":{},"ISSN":["2308-3425"],"issn-type":[{"type":"electronic","value":"2308-3425"}],"subject":[],"published":{"date-parts":[[2024,1,6]]}}}