{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:12Z","timestamp":1787028612885,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T00:00:00Z","timestamp":1710288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>(1) Background: Left ventricular global longitudinal (LVGLS) and right ventricular free wall strain (RVFWS) demonstrated separate prognostic values in patients with severe aortic stenosis (AS). However, studies evaluating the combined assessment of LVGLS and RVFWS have shown contradictory results. This study explored the prognostic value of combining LVGLS and RVFWS in a large group of severe AS patients referred for transcatheter aortic valve implantation. (2) Methods: Patients were classified into three groups: preserved (LVGLS \u2265 15% AND RVFWS &gt; 20%), single-ventricle impaired (LVGLS &lt; 15% OR RVFWS \u2264 20%), or biventricular-impaired strain group (LVGLS &lt; 15% AND RVFWS \u2264 20%). The cut-off values were based on previously published data and spline analyses. The endpoint was all-cause mortality. (3) Results: Of the 712 patients included (age 80 \u00b1 7 years, 53% men), 248 (35%) died. The single-ventricle impaired and biventricular-impaired (vs. preserved) strain groups showed significantly lower 5-year survival rates (68% and 55% vs. 77%, respectively, p &lt; 0.001). Through multivariable analysis, single-ventricle impaired (HR 1.762; 95% CI: 1.114\u20132.788; p = 0.015) and biventricular-impaired strain groups (HR 1.920; 95% CI: 1.134\u20133.250; p = 0.015) were independently associated with all-cause mortality. These findings were confirmed with a sensitivity analysis in patients with preserved LV ejection fraction. (4) Conclusions: In patients with severe AS, biventricular strain allows better risk stratification, even if LV ejection fraction is preserved.<\/jats:p>","DOI":"10.3390\/jcdd11030090","type":"journal-article","created":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T03:46:31Z","timestamp":1710301591000},"page":"90","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incremental Value of Biventricular Strain in Patients with Severe Aortic Stenosis"],"prefix":"10.3390","volume":"11","author":[{"given":"Camille","family":"Sarrazyn","sequence":"first","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"},{"name":"Department of Cardiology, Ghent University Hospital, 9000 Gent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6294-7668","authenticated-orcid":false,"given":"Xavier","family":"Galloo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"},{"name":"Department of Cardiology, Free University Brussels (VUB), University Hospital Brussels (UZ Brussel), 1090 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-0555","authenticated-orcid":false,"given":"Maria Chiara","family":"Meucci","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"},{"name":"Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00136 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steele C.","family":"Butcher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"},{"name":"Department of Cardiology, Royal Perth Hospital, Perth 6000, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Hirsawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"},{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinchyenkhand","family":"Myagmardorj","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van der Kley","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-8766","authenticated-orcid":false,"given":"Tine","family":"De Backer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ghent University Hospital, 9000 Gent, Belgium"},{"name":"Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen J.","family":"Bax","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7208-5769","authenticated-orcid":false,"given":"Nina","family":"Ajmone Marsan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leiden University Medical Center, 2300ZA Leiden, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging Classification of Aortic Stenosis Based on the Extent of Cardiac Damage","volume":"38","author":"Pibarot","year":"2017","journal-title":"Eur. 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