{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:18:34Z","timestamp":1777594714788,"version":"3.51.4"},"reference-count":71,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Congestive heart failure (CHF) is associated with significant morbidity and mortality. There has been renewed interest in using thrombo-inflammatory markers as prognostic tools in patients with CHF. To determine if thrombo-inflammatory markers are independent risk factors for 28-day mortality in hospitalized CHF patients, we retrospectively analyzed admission data extracted from 2008 consecutive patients admitted with a diagnosis of CHF to Zigong Fourth People\u2019s Hospital. Multivariate Cox proportional hazards analysis demonstrated that the thrombo-inflammatory markers thrombin time, platelet\/lymphocyte ratio (PLR), and D-dimer level were independent predictors of mortality. In addition, variables reflecting the severity of CHF (New York Heart Association class &gt; 2), impaired renal function (elevated serum creatinine [SCr]), impaired organ perfusion (elevated BUN), and chronic liver disease were also independent predictors of mortality. Thrombo-inflammatory biomarkers were only weakly associated with SCr and the burden of co-morbidity, suggesting that thrombo-inflammation may in large part be attributable to CHF itself and that, moreover, its presence may confer an increased risk of mortality. Further large-scale prospective studies are needed to determine the existence and the consequences of a thrombo-inflammatory phenotype among patients with CHF.<\/jats:p>","DOI":"10.3390\/jcdd11030093","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T09:14:33Z","timestamp":1710926073000},"page":"93","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Short-Term Mortality in Hospitalized Patients with Congestive Heart Failure: Markers of Thrombo-Inflammation Are Independent Risk Factors and Only Weakly Associated with Renal Insufficiency and Co-Morbidity Burden"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7851-0498","authenticated-orcid":false,"given":"Jose","family":"Iglesias","sequence":"first","affiliation":[{"name":"Department of Medicine Rutgers Health Community Medical Center Internal Medicine Residency Program, Community Medical Center RWJBH, Toms River, NJ 08757, USA"},{"name":"Department of Medicine, Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Okoh","sequence":"additional","affiliation":[{"name":"Department of Medicine Rutgers Health Community Medical Center Internal Medicine Residency Program, Community Medical Center RWJBH, Toms River, NJ 08757, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-9880","authenticated-orcid":false,"given":"Song Peng","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Medicine Rutgers Health Community Medical Center Internal Medicine Residency Program, Community Medical Center RWJBH, Toms River, NJ 08757, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1568-2291","authenticated-orcid":false,"given":"Cristina A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Medicine Rutgers Health Community Medical Center Internal Medicine Residency Program, Community Medical Center RWJBH, Toms River, NJ 08757, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Ee","family":"Chia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Texas Tech University Health Science Center, El Paso, TX 79905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerrold S.","family":"Levine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Nephrology, University of Illinois Chicago, Chicago, IL 60612, USA"},{"name":"Department of Medicine, Division of Nephrology, Jesse Brown Veterans Affairs Medical Center, Chicago, IL 60612, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e027852","DOI":"10.1161\/JAHA.122.027852","article-title":"Burden, Trends, and Inequalities of Heart Failure Globally, 1990 to 2019: A Secondary Analysis Based on the Global Burden of Disease 2019 Study","volume":"12","author":"Yan","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e018696","DOI":"10.1161\/JAHA.120.018696","article-title":"Regional variations in heart failure quality and outcomes: Get with the guidelines\u2014Heart failure registry","volume":"10","author":"Cunningham","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.jacc.2013.11.053","article-title":"The global health and economic burden of hospitalizations for heart failure: Lessons learned from hospitalized heart failure registries","volume":"63","author":"Ambrosy","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics\u20142020 Update: A Report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1093\/cvr\/cvac013","article-title":"Global burden of heart failure: A comprehensive and updated review of epidemiology","volume":"118","author":"Savarese","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/ejhf.813","article-title":"Epidemiology and one-year outcomes in patients with chronic heart failure and preserved, mid-range and reduced ejection fraction: An analysis of the ESC Heart Failure Long-Term Registry","volume":"19","author":"Chioncel","year":"2017","journal-title":"Eur. J. Heart Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e008943","DOI":"10.1161\/CIRCHEARTFAILURE.121.008943","article-title":"Trends in characteristics and outcomes in primary heart failure hospitalizations among older population in the United States, 2004 to 2018","volume":"15","author":"Minhas","year":"2022","journal-title":"Circ. Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.18410\/jebmh\/2016\/360","article-title":"New horizons in the management of heart failure","volume":"3","author":"Gupta","year":"2016","journal-title":"J. Evid. Based Med. Healthc."},{"key":"ref_9","first-page":"548","article-title":"Prevalence, outcomes and costs of a contemporary, multinational population with heart failure","volume":"109","author":"Norhammar","year":"2023","journal-title":"Heart"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1001\/archinte.164.11.1186","article-title":"Provider and hospital characteristics associated with geographic variation in the evaluation and management of elderly patients with heart failure","volume":"164","author":"Havranek","year":"2004","journal-title":"Arch. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e012884","DOI":"10.1161\/JAHA.119.012884","article-title":"Characteristics, Management, and Outcomes of Patients Hospitalized for Heart Failure in China: The China PEACE Retrospective Heart Failure Study","volume":"8","author":"Yu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/ejhf.566","article-title":"European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions","volume":"18","author":"Anker","year":"2016","journal-title":"Eur. J. Heart Fail."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1001\/jama.293.5.572","article-title":"The Risk Stratification for In-Hospital Risk Stratification for In-Hospital Mortality in Acutely Decompensated Heart FailureClassification and Regression Tree Analysis","volume":"293","author":"Fonarow","year":"2005","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s10741-005-6129-4","article-title":"The cardiorenal syndrome: Lessons from the ADHERE database and treatment options","volume":"9","author":"Heywood","year":"2004","journal-title":"Heart Fail. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"B13","DOI":"10.1093\/eurheartj\/sui008","article-title":"Reassessing treatment of acute heart failure syndromes: The ADHERE Registry","volume":"7","author":"Gheorghiade","year":"2005","journal-title":"Eur. Heart J. Suppl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ahj.2006.10.043","article-title":"Epidemiology and risk stratification in acute heart failure","volume":"155","author":"Fonarow","year":"2008","journal-title":"Am. Heart J."},{"key":"ref_17","first-page":"20","article-title":"Combining Natriuretic Peptides and Necrosis Markers in Determining Prognosis in Heart Failure","volume":"4","author":"Gregg","year":"2003","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/j.jacc.2007.02.037","article-title":"Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure","volume":"49","author":"Fonarow","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jacc.2005.09.022","article-title":"Clinical presentation, management, and in-hospital outcomes of patients admitted with acute decompensated heart failure with preserved systolic function: A report from the Acute Decompensated Heart Failure National Registry (ADHERE) Database","volume":"47","author":"Yancy","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ahj.2004.08.005","article-title":"Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)","volume":"149","author":"Adams","year":"2005","journal-title":"Am. Heart J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/eurheartj\/ehl542","article-title":"Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: An analysis from the OPTIMIZE-HF registry","volume":"28","author":"Gheorghiade","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jacc.2021.05.002","article-title":"Kidney Function and Outcomes in Patients Hospitalized with Heart Failure","volume":"78","author":"Patel","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/ejhf.32","article-title":"Predicting Survival in Heart Failure: Validation of the MAGGIC Heart Failure Risk Score in 51043 Patients From the Swedish Heart Failure Registry","volume":"16","author":"Sartipy","year":"2014","journal-title":"Eur. J. Heart Fail."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.2215\/CJN.03150509","article-title":"Cardiorenal Syndrome in Acute Decompensated Heart Failure","volume":"4","author":"Sarraf","year":"2009","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1002\/ehf2.13390","article-title":"The impact of platelet indices on clinical outcome in heart failure: Results from the MyoVasc study","volume":"8","author":"Dahlen","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_26","first-page":"e47441","article-title":"The Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio for Long-Term Survival in Patients with Severe Left Ventricular Dysfunction and Implantable Cardioverter Defibrillator","volume":"15","year":"2023","journal-title":"Cureus"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10741-011-9261-3","article-title":"Inflammatory Activation: Cardiac, Renal, and Cardio-Renal Interactions in Patients with the Cardiorenal Syndrome","volume":"17","author":"Colombo","year":"2012","journal-title":"Heart Fail. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.hfc.2009.04.001","article-title":"Inflammatory Biomarkers in Heart Failure Revisited: Much More Than Innocent Bystanders","volume":"5","author":"Schefold","year":"2009","journal-title":"Heart Fail Clin."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.56941\/odutip.1273205","article-title":"The Relationship between Recurrent Hospitalization and Inflammation in Heart Failure Patients","volume":"10","author":"Yasemin","year":"2023","journal-title":"OD\u00dc T\u0131p Derg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11239-011-0635-0","article-title":"Increased d-dimer levels predict cardiovascular mortality in patients with systolic heart failure","volume":"33","author":"Zorlu","year":"2012","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_31","first-page":"621","article-title":"D-dimer level and long-term outcome in patients with end-stage heart failure secondary to idiopathic dilated cardiomyopathy","volume":"16","author":"Huang","year":"2019","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41597-021-00835-9","article-title":"Electronic healthcare records and external outcome data for hospitalized patients with heart failure","volume":"8","author":"Zhang","year":"2021","journal-title":"Sci. Data"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"c1475","DOI":"10.1136\/bmj.c1475","article-title":"Potential of an age adjusted D-dimer cut-off value to improve the exclusion of pulmonary embolism in older patients: A retrospective analysis of three large cohorts","volume":"340","author":"Douma","year":"2010","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1007\/s40520-021-01805-2","article-title":"Charlson Co-morbidity Index as a predictor of repeated hospital admission and mortality among older women diagnosed with cardiovascular disease","volume":"33","author":"Shebeshi","year":"2021","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/1536867X1301300407","article-title":"Little\u2019s Test of Missing Completely at Random","volume":"13","author":"Li","year":"2013","journal-title":"Stata J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1016\/j.jacc.2009.12.045","article-title":"Inflammatory Markers and Incident Heart Failure Risk in Older Adults","volume":"55","author":"Kalogeropoulos","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"H2148","DOI":"10.1152\/ajpheart.00907.2011","article-title":"Inflammation and metabolic dysfunction: Links to cardiovascular diseases","volume":"302","author":"Taube","year":"2012","journal-title":"Am. J. Physiol. -Heart Circ. Physiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/CIRCULATIONAHA.110.979203","article-title":"Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community","volume":"124","author":"Lam","year":"2011","journal-title":"Circulation"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A Novel Paradigm for Heart Failure with Preserved Ejection Fraction: Co-morbidities Drive Myocardial Dysfunction and Remodeling through Coronary Microvascular Endothelial Inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.15420\/ecr.2020.50","article-title":"Inflammation and Cardiovascular Disease: The Future","volume":"16","author":"Arnold","year":"2021","journal-title":"Eur. Cardiol. Rev."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jacc.2020.01.014","article-title":"Inflammation in Heart Failure: JACC State-of-the-Art Review","volume":"75","author":"Murphy","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-2141.2004.04977.x","article-title":"Haemostatic and Inflammatory Biomarkers in Advanced Chronic Heart Failure: Role of Oral Anticoagulants and Successful Heart Transplantation","volume":"126","author":"Cugno","year":"2004","journal-title":"Br. J. Haematol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"H877","DOI":"10.1152\/ajpheart.00223.2019","article-title":"Inflammation in nonischemic heart disease: Initiation by cardiomyocyte CaMKII and NLRP3 inflammasome signaling","volume":"317","author":"Suetomi","year":"2019","journal-title":"Am. J. Physiol.-Heart Circ. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cardiores.2006.01.013","article-title":"Autonomic imbalance and immune activation in chronic heart failure\u2013pathophysiological links","volume":"70","author":"Jankowska","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.jacc.2018.06.050","article-title":"Identifying Pathophysiological Mechanisms in Heart Failure with Reduced Versus Preserved Ejection Fraction","volume":"72","author":"Tromp","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.122.060860","article-title":"NLRP3 inflammasome activation through heart-brain interaction initiates cardiac inflammation and hypertrophy during pressure overload","volume":"147","author":"Higashikuni","year":"2023","journal-title":"Circulation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/j.1742-1241.2007.01313.x","article-title":"Immune activation and inflammatory system in chronic heart failure: Novel pathophysiological hypotheses generate new therapeutic options","volume":"61","author":"Piepoli","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2147\/VHRM.S394765","article-title":"Platelet, Neutrophil and Lymphocyte Quantitative Abnormalities in Patients with Heart Failure: A Retrospective Study","volume":"19","author":"Getawa","year":"2023","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_50","first-page":"100981","article-title":"Absolute lymphocyte count as a predictor of mortality and readmission in heart failure hospitalization","volume":"39","author":"Majmundar","year":"2022","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Wu, C.C., Wu, C.H., Lee, C.H., and Cheng, C.I. (2023). Association between neutrophil percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and long-term mortality in community-dwelling adults with heart failure: Evidence from US NHANES 2005\u20132016. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03316-6"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"104267","DOI":"10.1016\/j.yexmp.2019.104267","article-title":"Evaluation of complete blood count parameters in cardiovascular diseases: An early indicator of prognosis?","volume":"110","author":"Haybar","year":"2019","journal-title":"Exp. Mol. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"17828","DOI":"10.1038\/s41598-017-17754-8","article-title":"Hemographic Indices Are Associated with Mortality in Acute Heart Failure","volume":"7","author":"Huang","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0165-2478(99)00148-0","article-title":"Role of neutrophils in release of some cytokines and their soluble receptors","volume":"70","author":"Jablonska","year":"2000","journal-title":"Immunol. Lett."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.amjcard.2004.10.009","article-title":"Circulating levels of pro-inflammatory cytokines and neutrophil-platelet aggregates in patients with coronary artery disease","volume":"95","author":"Nijm","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.tracli.2012.02.004","article-title":"Platelets and cytokines: How and why?","volume":"19","author":"Garraud","year":"2012","journal-title":"Transfus. Clin. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1055\/s-0041-1731288","article-title":"Rapid Release of Interleukin-1\u03b2 From Human Platelets Is Independent of NLRP3 and Caspase","volume":"122","author":"Pennings","year":"2022","journal-title":"Thromb. Haemost."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1083\/jcb.200105058","article-title":"Activated Platelets Mediate Inflammatory Signaling by Regulated Interleukin 1\u03b2 Synthesis","volume":"154","author":"Lindemann","year":"2001","journal-title":"J. Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"e935002","DOI":"10.12659\/MSM.935002","article-title":"Retrospective Study of the Association between Platelet-to-Lymphocyte Ratio in Patients with Acute Coronary Syndrome on Admission to a Rural Referral Center in East Java, Indonesia, and the Incidence of New Symptomatic Heart Failure at 6 Months","volume":"28","author":"Intan","year":"2022","journal-title":"Med. Sci. Monit."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.amjcard.2014.10.008","article-title":"Usefulness of neutrophil-to-lymphocyte ratio in risk stratification of patients with advanced heart failure","volume":"115","author":"Hernandez","year":"2015","journal-title":"Am. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2217\/bmm-2017-0193","article-title":"Platelet-lymphocyte ratio in prediction of outcome of acute heart failure","volume":"12","author":"Pourafkari","year":"2018","journal-title":"Biomark. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Heidarpour, M., Bashiri, S., Vakhshoori, M., Heshmat-Ghahdarijani, K., Khanizadeh, F., Ferdowsian, S., and Shafie, D. (2021). The Association between Platelet-to-Lymphocyte Ratio with Mortality among Patients Suffering from Acute Decompensated Heart Failure. BMC Cardiovasc. Disord., 21.","DOI":"10.1186\/s12872-021-02260-7"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"10639","DOI":"10.1038\/s41598-019-47143-2","article-title":"The Prognostic Role of Platelet-to-Lymphocyte Ratio in Patients with Acute Heart Failure: A Cohort Study","volume":"9","author":"Ye","year":"2019","journal-title":"Sci Rep."},{"key":"ref_64","first-page":"606","article-title":"Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are Predictors of Heart Failure","volume":"105","author":"Durmus","year":"2015","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_65","first-page":"84","article-title":"The Platelet to Lymphocyte Ratio in Heart Failure: A Comprehensive Review","volume":"61","author":"Delcea","year":"2023","journal-title":"Rom. J. Intern. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jemermed.2018.06.021","article-title":"Platelet to Lymphocyte Ratio on Admission and Prognosis in Patients with Acute Cardiogenic Pulmonary Edema","volume":"55","author":"Demir","year":"2018","journal-title":"J. Emerg. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"13507","DOI":"10.1038\/s41598-018-31059-4","article-title":"Role of blood urea nitrogen in predicting the post-discharge prognosis in elderly patients with acute decompensated heart failure","volume":"8","author":"Ren","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cardfail.2016.06.423","article-title":"Relevance of Changes in Serum Creatinine During a Heart Failure Trial of Decongestive Strategies: Insights from the DOSE Trial","volume":"22","author":"Brisco","year":"2016","journal-title":"J. Card. Fail."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchf.2018.10.007","article-title":"Heart Failure and Liver Disease: Cardiohepatic Interactions","volume":"7","author":"Xanthopoulos","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Fortea, J.I., Puente, \u00c1., Cuadrado, A., Huelin, P., Pell\u00f3n, R., Gonz\u00e1lez S\u00e1nchez, F.J., Mayorga, M., Cagigal, M.L., Garc\u00eda Carrera, I., and Cobreros, M. (2020). Congestive Hepatopathy. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21249420"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cce2.63","article-title":"Cardiohepatic interactions in heart failure: Clinical and therapeutic implications","volume":"3","author":"Nikolaou","year":"2017","journal-title":"Contin. Cardiol. 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