{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:14:22Z","timestamp":1780406062776,"version":"3.54.1"},"reference-count":58,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The ductus arteriosus represents an essential vascular structure connecting the pulmonary artery and the aorta. Over the past decades, there has been substantial advancement in our understanding of both the fundamental and clinical aspects of the ductus arteriosus. In particular, the clarification of the regulatory mechanisms governing ductal patency in critical stages such as the fetal and the perinatal period has enabled optimal management of both physiological and pathological conditions in which the ductus arteriosus plays a crucial role. Furthermore, a more in-depth understanding of the regulatory mechanisms controlling this fundamental structure has facilitated the development of advanced therapeutic strategies and personalized interventions. In the present review, we provide a comprehensive overview of the ductus arteriosus during fetal and perinatal life, encompassing its physiological functions, pathological conditions, and clinical implications. Through this examination, we aim to contribute to a broader understanding of the ductus arteriosus\u2019 role in these critical developmental stages and its significance in clinical practice.<\/jats:p>","DOI":"10.3390\/jcdd11040113","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T05:42:43Z","timestamp":1711950163000},"page":"113","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Ductus Arteriosus in Fetal and Perinatal Life"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9509-6778","authenticated-orcid":false,"given":"Flaminia","family":"Pugnaloni","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit, Fetal Neonatal and Cardiological Science Research Area, \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Doni","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Fondazione IRCCS San Gerardo Dei Tintori, 20900 Monza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Lucente","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Azienda Ospedaliera di Cosenza, 87100 Cosenza, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Fiocchi","sequence":"additional","affiliation":[{"name":"Pediatric Department, G. Fornaroli Hospital, 20013 Magenta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3090-2887","authenticated-orcid":false,"given":"Irma","family":"Capolupo","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit, Fetal Neonatal and Cardiological Science Research Area, \u201cBambino Ges\u00f9\u201d Children\u2019s Hospital, IRCCS, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1159\/000308367","article-title":"History of the Ductus Arteriosus: 1. 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