{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:04:03Z","timestamp":1760144643650,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"],"award-info":[{"award-number":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"European Regional Development Fund (ERDF) \u2018A way of making Europe\u2019 (\u00c1.A.) and the Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"],"award-info":[{"award-number":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Research Council (ERC)","award":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"],"award-info":[{"award-number":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"]}]},{"DOI":"10.13039\/501100004837","name":"Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"],"award-info":[{"award-number":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ISCIII","award":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"],"award-info":[{"award-number":["PI19\/00655","PI20\/0923","RTC2019-006826-1","819775","PID2019-107332RB-I00","SEV-2015-0505"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Transthyretin cardiac amyloidosis (ATTR amyloidosis) is a frequent etiology of heart failure. Inflammation and mineral metabolism are associated with myocardial dysfunction and clinical performance. Cardiac global longitudinal strain (GLS) allows function assessment and is associated with prognosis. Our aim was to describe possible correlations between GLS, biomarker levels and clinical performance in ATTR amyloidosis. Methods: Thirteen patients with ATTR amyloidosis were included. Clinical characteristics; echocardiographic features, including strain assessment and 6 min walk test (6MWT); and baseline inflammatory, mineral metabolism and cardiovascular biomarker levels were assessed. Results: Of the 13 patients, 46.2% were women, and the mean age was 79 years. TAPSE correlated with NT-ProBNP (r \u22120.65, p &lt; 0.05) and galectin-3 (r 0.76, p &lt; 0.05); E\/E\u2032 ratio correlated with hsCRP (r 0.58, p &lt; 0.05). Left ventricular GLS was associated with NT-ProBNP (r 0.61, p &lt; 0.05) (patients have a better prognosis if the strain value is more negative) and left atrial GLS with NT-ProBNP (r \u22120.73, p &lt; 0.05) and MCP1 (r 0.55, p &lt; 0.05). Right ventricular GLS was correlated with hsTnI (r 0.62, p &lt; 0.05) and IL6 (r 0.881, p &lt; 0.05). Klotho levels were correlated with 6MWT (r 0.57, p &lt; 0.05). Conclusions: While inflammatory biomarkers were correlated with cardiac function, klotho levels were associated with clinical performance in the population with TTR-CA.<\/jats:p>","DOI":"10.3390\/jcdd11050142","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T03:30:49Z","timestamp":1714534249000},"page":"142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Serum Biomarkers and Their Association with Myocardial Function and Exercise Capacity in Cardiac Transthyretin Amyloidosis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0645-0902","authenticated-orcid":false,"given":"Luis","family":"Nieto-Roca","sequence":"first","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fern\u00e1ndez Almagro, 3, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0592-598X","authenticated-orcid":false,"given":"Andrea","family":"Camblor Blasco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fern\u00e1ndez Almagro, 3, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Devesa","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fern\u00e1ndez Almagro, 3, 28029 Madrid, Spain"},{"name":"Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"G\u00f3mez-Talavera","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fern\u00e1ndez Almagro, 3, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Balaguer-Germ\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3458-0328","authenticated-orcid":false,"given":"Jairo","family":"Lumpuy-Castillo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Medicine Department, Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Spanish Biomedical Research Centre on Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u00eda","family":"Pello","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Mart\u00ednez","family":"Dhier","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Av. Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregoria","family":"Lape\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Av. Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-7182","authenticated-orcid":false,"given":"Luc\u00eda Llanos","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Research Unit, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, 28002 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-6078","authenticated-orcid":false,"given":"\u00d3scar","family":"Lorenzo","sequence":"additional","affiliation":[{"name":"Laboratory of Diabetes and Vascular Pathology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Medicine Department, Universidad Aut\u00f3noma, 28040 Madrid, Spain"},{"name":"Spanish Biomedical Research Centre on Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-0999","authenticated-orcid":false,"given":"Jos\u00e9","family":"Tu\u00f1\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"},{"name":"Faculty of Medicine, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Melchor Fern\u00e1ndez Almagro, 3, 28029 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1lvaro","family":"Ace\u00f1a","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IIS-Fundaci\u00f3n Jim\u00e9nez D\u00edaz University Hospital-Quironsalud, Avenida Reyes Cat\u00f3licos, 2, 28040 Madrid, Spain"},{"name":"Faculty of Medicine, Universidad Aut\u00f3noma de Madrid, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1001\/jamacardio.2021.3070","article-title":"Prevalence of Transthyretin Amyloid Cardiomyopathy in Heart Failure with Preserved Ejection Fraction","volume":"6","author":"AbouEzzeddine","year":"2021","journal-title":"JAMA Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1093\/eurheartj\/ehv338","article-title":"Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction","volume":"36","author":"Robles","year":"2015","journal-title":"Eur. 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