{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:43:50Z","timestamp":1793918630926,"version":"4.8.0"},"reference-count":84,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The ligament of Marshall is an epicardial structure characterized by its composition of fat, fibrous tissue, blood vessels, muscle bundles, nerve fibers, and ganglia. Its intricate network forms muscular connections with the coronary sinus and left atrium, alongside adjacent autonomic nerves and ganglion cells. This complexity plays a pivotal role in initiating focal electrical activities and sustaining micro- and macro-reentrant circuits, thereby contributing to the onset of atrial fibrillation and atrial tachycardia. However, endocardial ablation in this area may encounter challenges due to anatomical variations and insulation by fibrofatty tissue. Combining ethanol infusion into the vein of Marshall with radiofrequency ablation presents a promising strategy for effectively and safely eliminating this arrhythmogenic structure and terminating associated tachycardias.<\/jats:p>","DOI":"10.3390\/jcdd11070183","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:50:08Z","timestamp":1718959808000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Ethanol Infusion to the Vein of Marshall in Atrial Fibrillation and Atrial Tachycardia"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8473-7514","authenticated-orcid":false,"given":"Masateru","family":"Takigawa","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"},{"name":"Department of Advanced Arrhythmia Research, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsuke","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"},{"name":"Department of Advanced Arrhythmia Research, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"ref_1","first-page":"133","article-title":"On the development of the great anterior veins in man and mammalia; including an account of certain remnants of f\u0153tal structure found in the adult, a comparative view of these great veins the different mammalia, and an analysis of their occasional peculia","volume":"140","author":"Marshall","year":"1850","journal-title":"Philos. Trans. R. Soc. Lond."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/S0735-1097(00)00819-6","article-title":"The Ligament of Marshall: A Structural Analysis in Human Hearts with Implications for Atrial Arrhythmias","volume":"36","author":"Kim","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1161\/01.CIR.101.13.1503","article-title":"Vein of Marshall Cannulation for the Analysis of Electrical Activity in Patients With Focal Atrial Fibrillation","volume":"101","author":"Hwang","year":"2000","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1540-8167.2006.00542.x","article-title":"Marshall Vein as Arrhythmogenic Source in Patients with Atrial Fibrillation: Correlation between Its Anatomy and Electrophysiological Findings","volume":"17","author":"Kurotobi","year":"2006","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.hrthm.2006.09.014","article-title":"How and When to Ablate the Ligament of Marshall","volume":"3","author":"Hwang","year":"2006","journal-title":"Heart Rhythm"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1152\/ajpheart.00369.2005","article-title":"Electrical Connections between Left Superior Pulmonary Vein, Left Atrium, and Ligament of Marshall: Implications for Mechanisms of Atrial Fibrillation","volume":"290","author":"Tan","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1161\/01.CIR.100.8.876","article-title":"Relation between Ligament of Marshall and Adrenergic Atrial Tachyarrhythmia","volume":"100","author":"Doshi","year":"1999","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/01.CIR.103.8.1157","article-title":"Pulmonary Veins and Ligament of Marshall as Sources of Rapid Activations in a Canine Model of Sustained Atrial Fibrillation","volume":"103","author":"Wu","year":"2001","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.hrthm.2019.05.019","article-title":"The Role of Marshall Bundle Epicardial Connections in Atrial Tachycardias after Atrial Fibrillation Ablation","volume":"16","author":"Vlachos","year":"2019","journal-title":"Heart Rhythm"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jacep.2015.08.011","article-title":"Peri-Mitral Atrial Tachycardia Using the Marshall Bundle Epicardial Connections","volume":"2","author":"Hayashi","year":"2016","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e007273","DOI":"10.1161\/CIRCEP.119.007273","article-title":"Mechanism of Recurrence of Atrial Tachycardia: Comparison between First versus Redo Procedures in a High-Resolution Mapping System","volume":"13","author":"Takigawa","year":"2020","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.hrthm.2021.03.038","article-title":"Differentiating Atrial Tachycardias with Centrifugal Activation: Lessons from High-Resolution Mapping","volume":"18","author":"Takigawa","year":"2021","journal-title":"Heart Rhythm"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1111\/jce.15186","article-title":"Characteristics of Macroreentrant Atrial Tachycardias Using an Anatomical Bypass: Pseudo-Focal Atrial Tachycardia Case Series","volume":"32","author":"Nakatani","year":"2021","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"E010001","DOI":"10.1161\/CIRCEP.121.010001","article-title":"Vein of Marshall Ethanol Infusion: Feasibility, Pitfalls, and Complications in over 700 Patients","volume":"14","author":"Kamakura","year":"2021","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/pace.14617","article-title":"Vein of Marshall Ethanol Infusion: First-Step or Adjunctive Choice for Perimitral Atrial Tachycardia?","volume":"46","author":"Gao","year":"2023","journal-title":"PACE-Pacing Clin. Electrophysiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.hrthm.2012.03.008","article-title":"Ethanol Infusion in the Vein of Marshall Facilitates Mitral Isthmus Ablation","volume":"9","author":"Morales","year":"2012","journal-title":"Heart Rhythm"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1111\/jce.14019","article-title":"Ethanol Infusion for Marshall Bundle Epicardial Connections in Marshall Bundle-Related Atrial Tachycardias Following Atrial Fibrillation Ablation: The Accessibility and Success Rate of Ethanol Infusion by Using a Femoral Approach","volume":"30","author":"Kitamura","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jacep.2021.11.019","article-title":"Vein of Marshall Ethanol Infusion as First Step for Mitral Isthmus Linear Ablation","volume":"8","author":"Gillis","year":"2022","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jacep.2021.06.019","article-title":"Durability of Left Atrial Lesions After Ethanol Infusion in the Vein of Marshall","volume":"8","author":"Laredo","year":"2021","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e008884","DOI":"10.1161\/CIRCEP.120.008884","article-title":"Impact of Vein of Marshall Ethanol Infusion on Mitral Isthmus Block: Efficacy and Durability","volume":"13","author":"Nakashima","year":"2020","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1016\/j.hrthm.2009.07.036","article-title":"Ethanol Infusion in the Vein of Marshall: Adjunctive Effects during Ablation of Atrial Fibrillation","volume":"6","author":"Liu","year":"2009","journal-title":"Heart Rhythm"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1111\/jce.15107","article-title":"Durability of Mitral Isthmus Ablation with and without Ethanol Infusion in the Vein of Marshall","volume":"32","author":"Ishimura","year":"2021","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.hrthm.2021.03.032","article-title":"Vein of Marshall Ethanol Infusion in the Treatment of Atrial Fibrillation: From Concept to Clinical Practice","volume":"18","year":"2021","journal-title":"Heart Rhythm"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/pace.14052","article-title":"Ethanol Infusion into the Vein of Marshall for Recurrent Perimitral Atrial Tachycardia after Catheter Ablation for Persistent Atrial Fibrillation","volume":"44","author":"Sang","year":"2020","journal-title":"PACE-Pacing Clin. Electrophysiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/europace\/euaa137","article-title":"Acute and Mid-Term Outcome of Ethanol Infusion of Vein of Marshall for the Treatment of Perimitral Flutter","volume":"22","author":"Takigawa","year":"2020","journal-title":"Europace"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.hrthm.2019.01.031","article-title":"Clinical Impact of Ethanol Infusion into the Vein of Marshall on the Mitral Isthmus Area Evaluated by Atrial Electrograms Recorded inside the Coronary Sinus","volume":"16","author":"Kawaguchi","year":"2019","journal-title":"Heart Rhythm"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1540-8167.2006.00375.x","article-title":"Diverse Myocardial Extension and Autonomic Innervation on Ligament of Marshall in Humans","volume":"17","author":"Makino","year":"2006","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1016\/j.hrthm.2009.08.034","article-title":"Ligament of Marshall: Why It Is Important for Atrial Fibrillation Ablation","volume":"6","author":"Hwang","year":"2009","journal-title":"Heart Rhythm"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1152\/ajpheart.00139.2007","article-title":"The Ligament of Marshall as a Parasympathetic Conduit","volume":"293","author":"Ulphani","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jacep.2017.02.022","article-title":"The Human Left Atrial Venous Circulation as a Vascular Route for Atrial Pharmacological Therapies: Effects of Ethanol Infusion","volume":"3","author":"Morales","year":"2017","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1161\/01.RES.31.1.18","article-title":"Inferior Interatrial Pathway in the Dog","volume":"31","author":"Scherlag","year":"1972","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.hrthm.2010.02.028","article-title":"Electrophysiological Characteristics of the Marshall Bundle in Humans","volume":"7","author":"Han","year":"2010","journal-title":"Heart Rhythm"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1540-8167.2011.02268.x","article-title":"Role of the Vein of Marshall in Atrial Fibrillation Recurrences after Catheter Ablation: Therapeutic Effect of Ethanol Infusion","volume":"23","author":"Dave","year":"2012","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/jce.13969","article-title":"Long-Term Efficacy and Safety of Adjunctive Ethanol Infusion into the Vein of Marshall during Catheter Ablation for Nonparoxysmal Atrial Fibrillation","volume":"30","author":"Liu","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1161\/01.CIR.0000074206.52056.2D","article-title":"Catheter Ablation of Paroxysmal Atrial Fibrillation Initiated by Non-Pulmonary Vein Ectopy","volume":"107","author":"Lin","year":"2003","journal-title":"Circulation"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.31083\/j.rcm2504112","article-title":"Mechanisms of Vein of Marshall-Related Tachyarrhythmias and the Impact of Ethanol Infusion","volume":"25","author":"Takigawa","year":"2024","journal-title":"Rev. Cardiovasc. Med."},{"key":"ref_37","first-page":"29","article-title":"Epicardial Connections Involving Pulmonary Veins: The Prevalence, Predictors, and Implications for Ablation Outcome","volume":"13","author":"Betancur","year":"2020","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1540-8167.2006.00516.x","article-title":"Vein of Marshall Activity during Sustained Atrial Fibrillation","volume":"17","author":"Kamanu","year":"2006","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1111\/jce.13658","article-title":"Selective Ablation of the Ligament of Marshall Attenuates Atrial Electrical Remodeling in a Short-Term Rapid Atrial Pacing Canine Model","volume":"29","author":"Yu","year":"2018","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1016\/j.jacc.2014.01.032","article-title":"Ethanol Infusion in the Vein of Marshall Leads to Parasympathetic Denervation of the Human Left Atrium: Implications for Atrial Fibrillation","volume":"63","author":"Keida","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S0972-6292(16)30522-8","article-title":"A Review of Mitral Isthmus Ablation","volume":"12","author":"Wong","year":"2012","journal-title":"Indian Pacing Electrophysiol. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1001\/jama.2020.16195","article-title":"Effect of Catheter Ablation with Vein of Marshall Ethanol Infusion vs. Catheter Ablation Alone on Persistent Atrial Fibrillation: The VENUS Randomized Clinical Trial","volume":"324","author":"Peterson","year":"2020","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.hrthm.2021.01.005","article-title":"Determinants of Outcome Impact of Vein of Marshall Ethanol Infusion When Added to Catheter Ablation of Persistent Atrial Fibrillation: A Secondary Analysis of the VENUS Randomized Clinical Trial","volume":"18","author":"Lador","year":"2021","journal-title":"Heart Rhythm"},{"key":"ref_44","first-page":"871645","article-title":"The Long-Term Outcomes of Ablation With Vein of Marshall Ethanol Infusion vs. Ablation Alone in Patients With Atrial Fibrillation: A Meta-Analysis","volume":"9","author":"Li","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/pace.14263","article-title":"Feasibility, Efficacy, and Safety of Ethanol Infusion into the Vein of Marshall for Atrial Fibrillation: A Meta-Analysis","volume":"44","author":"He","year":"2021","journal-title":"PACE-Pacing Clin. Electrophysiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e24178","DOI":"10.1002\/clc.24178","article-title":"Efficacy and Feasibility of Vein of Marshall Ethanol Infusion during Persistent Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis","volume":"47","author":"Ge","year":"2023","journal-title":"Clin. Cardiol."},{"key":"ref_47","first-page":"20200492","article-title":"Adjunctive Vein of Marshall Ethanol Infusion during Atrial Fibrillation Ablation: A Systematic Review and Meta-Analysis","volume":"14","author":"Mhanna","year":"2021","journal-title":"J. Atr. Fibrillation"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4022\/jafib.2253","article-title":"Comparative Study of Cryoballoon versus Radiofrequency for Pulmonary Vein Isolation When Combined with Vein of Marshall Ethanol Infusion for Paroxysmal Atrial Fibrillation","volume":"12","author":"Okishige","year":"2020","journal-title":"J. Atr. Fibrillation"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1111\/jce.14221","article-title":"Potential Complications in Patients Undergoing an Ethanol Injection into the Vein of Marshall","volume":"30","author":"Kato","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jce.13797","article-title":"MARSHALL Bundles Elimination, Pulmonary Veins Isolation and Lines Completion for ANatomical Ablation of Persistent Atrial Fibrillation: MARSHALL-PLAN Case Series","volume":"30","author":"Pambrun","year":"2019","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.hrthm.2020.12.023","article-title":"Marshall Bundle Elimination, Pulmonary Vein Isolation, and Line Completion for ANatomical Ablation of Persistent Atrial Fibrillation (Marshall-PLAN): Prospective, Single-Center Study","volume":"18","author":"Derval","year":"2021","journal-title":"Heart Rhythm"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1111\/jce.15108","article-title":"Effectiveness of Ethanol Infusion into the Vein of Marshall Combined with a Fixed Anatomical Ablation Strategy (the \u201cUpgraded 2C3L\u201d Approach) for Catheter Ablation of Persistent Atrial Fibrillation","volume":"32","author":"Lai","year":"2021","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/jce.16115","article-title":"Comparison of the Effect of Ethanol Infusion into the Vein of Marshall between with and without Collateral Veins","volume":"35","author":"Ishimura","year":"2023","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ahj.2023.01.019","article-title":"Prospective Randomized Comparison between Upgraded \u20182C3L\u2019 vs. PVI Approach for Catheter Ablation of Persistent Atrial Fibrillation: PROMPT-AF Trial Design","volume":"260","author":"Liu","year":"2023","journal-title":"Am. Heart J."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"S398","DOI":"10.1016\/j.hrthm.2021.06.986","article-title":"B-Po05-066 Vein of Marshall Alcohol in Repeat Ablation of Persistent Atrial Fibrillation (Mars-Af)","volume":"18","author":"Lador","year":"2021","journal-title":"Heart Rhythm"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.hrthm.2010.10.015","article-title":"Comparison of Voltage Map-Guided Left Atrial Anterior Wall Ablation versus Left Lateral Mitral Isthmus Ablation in Patients with Persistent Atrial Fibrillation","volume":"8","author":"Pak","year":"2011","journal-title":"Heart Rhythm"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1093\/europace\/eup151","article-title":"High Take-off Left Inferior Pulmonary Vein as an Obstacle in Creating a Conduction Block at the Lateral Mitral Isthmus","volume":"11","author":"Takatsuki","year":"2009","journal-title":"Europace"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1540-8167.2005.50192.x","article-title":"Della Left Mitral Isthmus Ablation Associated with PV Isolation: Long-Term Results of a Prospective Randomized Study","volume":"16","author":"Fassini","year":"2005","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.hrthm.2009.09.067","article-title":"Peri-Mitral Atrial Flutter in Patients with Atrial Fibrillation Ablation","volume":"7","author":"Matsuo","year":"2010","journal-title":"Heart Rhythm"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"2996","DOI":"10.1161\/01.CIR.0000146917.75041.58","article-title":"Technique and Results of Linear Ablation at the Mitral Isthmus","volume":"110","author":"Hocini","year":"2004","journal-title":"Circulation"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1093\/eurheartj\/ehn302","article-title":"Left Atrial Linear Lesions Are Required for Successful Treatment of Persistent Atrial Fibrillation","volume":"29","author":"Knecht","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/europace\/euw423","article-title":"Spatial Relationship of Blood Vessels within the Mitral Isthmus Line","volume":"20","author":"Koziej","year":"2018","journal-title":"Europace"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ccep.2022.03.001","article-title":"Normal and Abnormal Atrial Anatomy Relevant to Atrial Flutters: Areas of Physiological and Acquired Conduction Blocks and Delays Predisposing to Re-Entry","volume":"14","author":"Ho","year":"2022","journal-title":"Card. Electrophysiol. Clin."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1540-8167.2004.03651.x","article-title":"Left Atrial Isthmus: Anatomic Aspects Relevant for Linear Catheter Ablation Procedures in Humans","volume":"15","author":"Becker","year":"2004","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/pace.13640","article-title":"Importance of the Vein of Marshall Involvement in Mitral Isthmus Ablation","volume":"42","author":"Fujisawa","year":"2019","journal-title":"PACE-Pacing Clin. Electrophysiol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e006933","DOI":"10.1161\/CIRCEP.118.006933","article-title":"Pseudoblock of the Posterior Mitral Line With Epicardial Bridging Connections Is a Frequent Cause of Complex Perimitral Tachycardias","volume":"12","author":"Barkagan","year":"2019","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jacep.2020.09.025","article-title":"Systematic Evaluation of High-Resolution Activation Mapping to Identify Residual Endocardial and Epicardial Conduction Across the Mitral Isthmus","volume":"7","author":"Sakamoto","year":"2021","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e005748","DOI":"10.1161\/CIRCEP.117.005748","article-title":"Endo-\/Epicardial Catheter Ablation of Atrial Fibrillation: Feasibility, Outcome, and Insights into Arrhythmia Mechanisms","volume":"11","author":"Piorkowski","year":"2018","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/europace\/eus051","article-title":"The Anatomical Characteristics of Three Different Endocardial Lines in the Left Atrium: Evaluation by Computed Tomography Prior to Mitral Isthmus Block Attempt","volume":"14","author":"Cho","year":"2012","journal-title":"Europace"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1793590","DOI":"10.1155\/2022\/1793590","article-title":"Comparison of the Anterior Septal Line and Mitral Isthmus Line for Perimitral Atrial Flutter Ablation Using Robotic Magnetic Navigation","volume":"2022","author":"Dang","year":"2022","journal-title":"J. Interv. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1540-8167.2009.01681.x","article-title":"The Modified Anterior Line: An Alternative Linear Lesion in Perimitral Flutter","volume":"21","author":"Tzeis","year":"2010","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e003175","DOI":"10.1161\/CIRCEP.115.003175","article-title":"Biatrial Tachycardia: Distinguishing Between Active and Passive Activation","volume":"9","author":"Ip","year":"2016","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e005558","DOI":"10.1161\/CIRCEP.117.005558","article-title":"Characteristics of Single-Loop Macroreentrant Biatrial Tachycardia Diagnosed by Ultrahigh-Resolution Mapping System","volume":"11","author":"Kitamura","year":"2018","journal-title":"Circ. Arrhythm. Electrophysiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jce.12543","article-title":"Biatrial Tachycardia Following Linear Anterior Wall Ablation for the Perimitral Reentry: Incidence and Electrophysiological Evaluations","volume":"26","author":"Mikhaylov","year":"2015","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.hrthm.2022.03.1228","article-title":"Effect of Radiofrequency and Ethanol Ablation on Epicardial Conduction through the Vein of Marshall: How to Detect and Manage Epicardial Connection across the Mitral Isthmus","volume":"19","author":"Kawaguchi","year":"2022","journal-title":"Heart Rhythm"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.hrthm.2021.03.023","article-title":"Significance of Manifest Localized Staining during Ethanol Infusion into the Vein of Marshall","volume":"18","author":"Takagi","year":"2021","journal-title":"Heart Rhythm"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.jacep.2023.11.027","article-title":"Efficiency and Durability of EIVOM on Acute Reconnection After Mitral Isthmus Bidirectional Block","volume":"10","author":"Zuo","year":"2024","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.hrthm.2013.10.030","article-title":"Transthoracic Epicardial Ablation of Mitral Isthmus for Treatment of Recurrent Perimitral Flutter","volume":"11","author":"Berruezo","year":"2014","journal-title":"Heart Rhythm"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0894-7317(05)80340-2","article-title":"Echocardiographic Evaluation of the Coronary Sinus","volume":"8","author":"Kronzon","year":"1995","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jacep.2021.09.020","article-title":"Optimized Computed Tomography Acquisition Protocol for Ethanol Infusion Into the Vein of Marshall","volume":"8","author":"Takagi","year":"2022","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/jce.15573","article-title":"Distribution of Atrial Low Voltage Induced by Vein of Marshall Ethanol Infusion","volume":"33","author":"Kamakura","year":"2022","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1093\/europace\/euac195","article-title":"Arrhythmogenic Epicardial LA-PV Connection at the Peri-Oesophageal Posterior LA Is Safely and Effectively Blocked by Ethanol Infusion to the Vein of Marshall","volume":"25","author":"Takigawa","year":"2023","journal-title":"Europace"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Landra, F., Nesti, M., Garibaldi, S., Mirizzi, G., Startari, U., Panchetti, L., Piacenti, M., Taddeucci, S., Formichi, B.A., and Stefani, M. (2024). A Proposed Index of Myocardial Staining for Vein of Marshall Ethanol Infusion: An Italian Single-Center Experience. J. Interv. Card. Electrophysiol., Online ahead of print.","DOI":"10.1007\/s10840-023-01732-4"},{"key":"ref_84","first-page":"661","article-title":"The Maine Vein of Marshall Ethanol Experience: Learning Curve and Safety","volume":"66","author":"Tandon","year":"2023","journal-title":"J. Interv. Card. Electrophysiol."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/7\/183\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:28Z","timestamp":1760108548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/7\/183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":84,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcdd11070183"],"URL":"https:\/\/doi.org\/10.3390\/jcdd11070183","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]}}}