{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:13:04Z","timestamp":1760145184242,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Centro de Investigaciones Cl\u00ednicas of Fundaci\u00f3n Valle del Lili, Cali, Colombia","award":["1835"],"award-info":[{"award-number":["1835"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Pre-existing (chronic) atrial fibrillation (AF) has been identified as a risk factor for cardiovascular complications and mortality in patients with COVID-19; however, evidence in Latin America (LATAM) is scarce. This prospective and multicenter study from the CARDIO COVID 19\u201320 database includes hospitalized adults with COVID-19 from 14 countries in LATAM. A parsimonious logistic regression model was used to identify the main factors associated with mortality in a simulated case-control setting comparing patients with a history of AF to those without. In total, 3260 patients were included, of which 115 had AF. The AF group was older, had a higher prevalence of comorbidities, and had greater use of cardiovascular medications. In the model, AF, chronic kidney disease, and a respiratory rate &gt; 25 at admission were associated with higher in-hospital mortality. The use of corticosteroids did not reach statistical significance; however, an effect was seen through the confidence interval. Thus, pre-existing AF increases mortality risk irrespective of other concomitant factors. Chronic kidney disease and a high respiratory rate at admission are also key factors for in-hospital mortality. These findings highlight the importance of comorbidities and regional characteristics in COVID-19 outcomes, in this instance, enhancing the evidence for patients from LATAM.<\/jats:p>","DOI":"10.3390\/jcdd11070210","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T06:28:54Z","timestamp":1720074534000},"page":"210","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre-Existing Atrial Fibrillation in Hospitalized Patients with COVID-19: Insights from the CARDIO COVID 19\u201320 Registry"],"prefix":"10.3390","volume":"11","author":[{"given":"Wikler","family":"Bernal Torres","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Departamento de Cardiolog\u00eda, Cali 760032, Colombia"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760032, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Pablo","family":"Arango-Ibanez","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas, Cali 760032, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Montero Echeverri","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Valle del Lili, Centro de Investigaciones Cl\u00ednicas, Cali 760032, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Posso Mar\u00edn","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali 760032, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Alvarado","sequence":"additional","affiliation":[{"name":"Hospital Especializado de Villa Nueva, Villa Nueva 01064, 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Cardiolog\u00eda, Fundaci\u00f3n Santa Fe de Bogot\u00e1, Bogot\u00e1 110111, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra Ines","family":"Christen","sequence":"additional","affiliation":[{"name":"Hospital Presidente Per\u00f3n, Buenos Aires B1872AWK, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Morr","sequence":"additional","affiliation":[{"name":"Comit\u00e9 de Cardiolog\u00eda Tropical\u2014Sociedad Venezolana de Cardiolog\u00eda, Caracas 1011, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos Santana","family":"Passos","sequence":"additional","affiliation":[{"name":"Hospital Ana Nery\u2014HAN\/SESAB, Salvador de Bah\u00eda 40301-155, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlon","family":"Aguirre","sequence":"additional","affiliation":[{"name":"Hospital Metropolitano, Quito 170521, 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Coronavirus Disease (COVID-19) Pandemic. Available online: https:\/\/www.who.int\/europe\/emergencies\/situations\/covid-19."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-022-01689-3","article-title":"Long-Term Cardiovascular Outcomes of COVID-19","volume":"28","author":"Xie","year":"2022","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ajem.2021.09.050","article-title":"Outcomes of Atrial Fibrillation in Patients with COVID-19 Pneumonia: A Systematic Review and Meta-Analysis","volume":"50","author":"Chen","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"ref_4","first-page":"23","article-title":"Desenlaces Cardiovasculares En Fibrilaci\u00f3n Auricular y COVID-19 Grave En Latinoam\u00e9rica: Registro CARDIO COVID 19-20","volume":"59","author":"Escalante","year":"2023","journal-title":"REC CardioClinics"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-022-00347-9","article-title":"Atrial Fibrillation","volume":"8","author":"Brundel","year":"2022","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dessie, Z.G., and Zewotir, T. (2021). Mortality-Related Risk Factors of COVID-19: A Systematic Review and Meta-Analysis of 42 Studies and 423,117 Patients. BMC Infect. Dis., 21.","DOI":"10.1186\/s12879-021-06536-3"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Donniacuo, M., De Angelis, A., Rafaniello, C., Cianflone, E., Paolisso, P., Torella, D., Sibilio, G., Paolisso, G., Castaldo, G., and Urbanek, K. (2023). COVID-19 and Atrial Fibrillation: Intercepting Lines. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1093053"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/joim.13499","article-title":"COVID-19 in Latin America and the Caribbean: Two Years of the Pandemic","volume":"292","author":"Schwalb","year":"2022","journal-title":"J. Intern. Med."},{"key":"ref_9","first-page":"576","article-title":"Stroke Prevention in Atrial Fibrillation: Focus on Latin America","volume":"107","author":"Massaro","year":"2016","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrcardio.2014.118","article-title":"Global Epidemiology of Atrial Fibrillation","volume":"11","author":"Rahman","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"40","DOI":"10.5334\/gh.1128","article-title":"Cardiovascular Risk Factors and Clinical Outcomes among Patients Hospitalized with COVID-19: Findings from the World Heart Federation COVID-19 Study","volume":"17","author":"Prabhakaran","year":"2022","journal-title":"Glob. Heart"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Evans-Gilbert, T., Figueroa, J.P., Bonveh\u00ed, P., Melgar, M., Stecher, D., Kfouri, R., Munoz, G., Bansie, R., Valenzuela, R., and Verne, E. (2024). Establishing Priorities to Strengthen National Immunization Technical Advisory Groups in Latin America and the Caribbean. Vaccine, 49.","DOI":"10.1016\/j.vaccine.2024.02.082"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5334\/gh.925","article-title":"Latin-American Registry of Cardiovascular Disease and COVID-19: Rationale and Design of the CARDIO COVID 19\u201320 Registry","volume":"16","author":"Montes","year":"2021","journal-title":"Glob. Heart"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5334\/gh.1272","article-title":"Latin-American Registry of Cardiovascular Disease and COVID-19: Final Results","volume":"18","author":"Galindo","year":"2023","journal-title":"Glob. Heart"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Genovesi, S., Rebora, P., Occhino, G., Rossi, E., Maloberti, A., Belli, M., Bonfanti, P., Giannattasio, C., Rossetti, C., and Epis, O.M. (2021). Atrial Fibrillation and Clinical Outcomes in a Cohort of Hospitalized Patients with Sars-Cov-2 Infection and Chronic Kidney Disease. J. Clin. Med., 10.","DOI":"10.3390\/jcm10184108"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s10840-021-00992-2","article-title":"Pre-Existing Atrial Fibrillation Is Associated with Increased Mortality in COVID-19 Patients","volume":"62","author":"Zuin","year":"2021","journal-title":"J. Interv. Card. Electrophysiol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Parahuleva, M.S., Harbaum, L., Patsalis, N., Parahuleva, N., Arndt, C., L\u00fcsebrink, U., Schieffer, B., and Kreutz, J. (2023). New-Onset Atrial Fibrillation in the Setting of COVID-19 Infection Is a Predictor of Mortality in Hospitalized Patients: CovAF-Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12103500"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Hosmer, D.W., Lemeshow, S., and Sturdivant, R.X. (2013). The Multiple Logistic Regression Model. Applied Logistic Regression, John Wiley & Sons, Ltd.","DOI":"10.1002\/9781118548387"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/jmv.27647","article-title":"Association of Atrial Fibrillation with Infectivity and Severe Complications of COVID-19: A Nationwide Cohort Study","volume":"94","author":"Park","year":"2022","journal-title":"J. Med. Virol."},{"key":"ref_20","first-page":"246","article-title":"COVID-19 en Latinoam\u00e9rica: Una revisi\u00f3n sistem\u00e1tica de la literatura y an\u00e1lisis bibliom\u00e9trico","volume":"22","year":"2023","journal-title":"Rev. Salud P\u00fablica"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.hroo.2023.10.004","article-title":"AF and In-Hospital Mortality in COVID-19 Patients","volume":"4","author":"Kotadia","year":"2023","journal-title":"Heart Rhythm O2"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.amjcard.2021.01.010","article-title":"Meta-Analysis of Atrial Fibrillation in Patients With COVID-19","volume":"144","author":"Yang","year":"2021","journal-title":"Am. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.recesp.2020.12.014","article-title":"Fibrilaci\u00f3n Auricular En Pacientes Con COVID-19. Utilidad de La Puntuaci\u00f3n CHA2DS2-VASc: Un An\u00e1lisis Del Registro Internacional HOPE COVID-19","volume":"74","author":"Uribarri","year":"2021","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.medcli.2022.01.008","article-title":"Factores de Riesgo de Mortalidad En Pacientes Con Infecci\u00f3n Por SARS-CoV-2 y Fibrilaci\u00f3n Auricular: Datos Del Registro SEMI-COVID-19","volume":"159","year":"2022","journal-title":"Med. Clin."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1053\/j.ajkd.2021.07.003","article-title":"Incidence and Outcomes of COVID-19 in People With CKD: A Systematic Review and Meta-Analysis","volume":"78","author":"Chung","year":"2021","journal-title":"Am. J. Kidney Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10238-021-00715-x","article-title":"Kidney Disease and COVID-19 Disease Severity\u2014Systematic Review and Meta-Analysis","volume":"22","author":"Singh","year":"2022","journal-title":"Clin. Exp. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1007\/s11255-020-02740-3","article-title":"Mortality in Chronic Kidney Disease Patients with COVID-19: A Systematic Review and Meta-Analysis","volume":"53","author":"Cai","year":"2021","journal-title":"Int. Urol. Nephrol."},{"key":"ref_28","first-page":"569","article-title":"Admission Respiratory Status Predicts Mortality in COVID-19. Influenza Other Respir","volume":"15","author":"Chatterjee","year":"2021","journal-title":"Viruses"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s11739-020-02509-7","article-title":"Early Predictors of In-Hospital Mortality in Patients with COVID-19 in a Large American Cohort","volume":"15","author":"Bahl","year":"2020","journal-title":"Intern. Emerg. Med."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Booth, A., Reed, A.B., Ponzo, S., Yassaee, A., Aral, M., Plans, D., Labrique, A., and Mohan, D. (2021). Population Risk Factors for Severe Disease and Mortality in COVID-19: A Global Systematic Review and Meta-Analysis. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0247461"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.12688\/f1000research.26186.2","article-title":"Predictors of COVID-19 Severity: A Systematic Review and Meta-Analysis","volume":"9","author":"Mudatsir","year":"2021","journal-title":"F1000Research"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, Sterne, J.A.C., Murthy, S., Diaz, J.V., Slutsky, A.S., Villar, J., Angus, D.C., Annane, D., Azevedo, L.C.P., and Berwanger, O. (2020). Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-Analysis. JAMA, 324, 1330\u20131341.","DOI":"10.1001\/jama.2020.17023"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.medcli.2022.03.013","article-title":"Effectiveness of Corticosteroids to Treat Coronavirus Disease 2019 Symptoms: A Meta-Analysis","volume":"159","author":"Zeng","year":"2022","journal-title":"Med. Clin. Engl. Ed."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e2386","DOI":"10.1002\/rmv.2386","article-title":"Effect of Corticosteroid Therapy on Mortality in COVID-19 Patients\u2014A Systematic Review and Meta-analysis","volume":"32","author":"Patel","year":"2022","journal-title":"Rev. Med. Virol."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Hong, S., Wang, H., Li, S., Liu, J., and Qiao, L. (2023). A Systematic Review and Meta-Analysis of Glucocorticoids Treatment in Severe COVID-19: Methylprednisolone versus Dexamethasone. BMC Infect. Dis., 23.","DOI":"10.1186\/s12879-023-08280-2"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/d41586-019-00857-9","article-title":"Scientists Rise up against Statistical Significance","volume":"567","author":"Amrhein","year":"2019","journal-title":"Nature"}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/7\/210\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:10:00Z","timestamp":1760109000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/7\/210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,4]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["jcdd11070210"],"URL":"https:\/\/doi.org\/10.3390\/jcdd11070210","relation":{},"ISSN":["2308-3425"],"issn-type":[{"type":"electronic","value":"2308-3425"}],"subject":[],"published":{"date-parts":[[2024,7,4]]}}}