{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:57:07Z","timestamp":1790827027222,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["GR-2019-12371213"],"award-info":[{"award-number":["GR-2019-12371213"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The aim of this study was to inviestigate cardiac and arterial remodelling before and after thoracic endovascular aortic repair (TEVAR) by measuring the Aorto-Septal Angle (AoSA) and the geometric characteristics of the aorta. Five patients were prospectively included. Pre- and post-operative cardio-CTA scans were used to create patient-specific 3D models to calculate the AoSA, defined by the intersection of the aortic and left ventricular axes. Additionally, geometric parameters and the inclination of the ascending aorta (AA) were measured. The results demonstrated a variation between pre- and post-operative AoSA in all patients, with an increase in the case of an aneurysmal disease from 112.36\u00b0 \u00b1 8.21\u00b0 to 117.16\u00b0 \u00b1 9.65\u00b0 (+4.1%, p = 0.041) and a decrease in the case of aortic dissection from 113.62\u00b0 \u00b1 0.96\u00b0 to 107.83\u00b0 \u00b1 1.45\u00b0 (\u22125.1%). Additionally, an increase in the length of both the outer and inner curvatures of the AA was observed from 102.21 \u00b1 10.17 mm to 105.73 \u00b1 11.2 mm (+ 3.33% p = 0.016) and from 55.55 \u00b1 9.53 mm to 58.35 \u00b1 9.96 mm (+4.8%, p = 0.04), respectively. This study introduced a new repeatable and reproducible method for assessing the AoSA using cardiac-CTA images. Thoracic stent deployment changes the AoSA, potentially impacting long-term left ventricle hemodynamics.<\/jats:p>","DOI":"10.3390\/jcdd11090275","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T05:54:47Z","timestamp":1725429287000},"page":"275","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the Aorto-Septal Angle Post-Thoracic Endovascular Aortic Repair through Segmentation and the Semi-Automatic Analysis of Cardiosynchronized Computed Tomography Angiography Images"],"prefix":"10.3390","volume":"11","author":[{"given":"Marco","family":"Magliocco","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine, University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1275-0653","authenticated-orcid":false,"given":"Michele","family":"Conti","sequence":"additional","affiliation":[{"name":"Deparment of Civil Engineering and Architecture, University of Pavia, 27100 Pavia, Italy"},{"name":"3D and Computer Simulation Laboratory, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Pane","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Integrated Surgical and Diagnostic Science (DISC), University of Genoa, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Canepa","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Genova, 16132 Genova, Italy"},{"name":"Department of Internal Medicine, University of Genoa, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Seitun","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Morganti","sequence":"additional","affiliation":[{"name":"Department of Electrical, Computer and Biomedical Engineering, University of Pavia, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Integrated Surgical and Diagnostic Science (DISC), University of Genoa, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-0199","authenticated-orcid":false,"given":"Giovanni","family":"Spinella","sequence":"additional","affiliation":[{"name":"Vascular and Endovascular Surgery Unit, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy"},{"name":"Department of Integrated Surgical and Diagnostic Science (DISC), University of Genoa, 16132 Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"55S","DOI":"10.1016\/j.jvs.2020.05.076","article-title":"Society for Vascular Surgery clinical practice guidelines of thoracic endovascular aortic repair for descending thoracic aortic aneurysms","volume":"73","author":"Upchurch","year":"2021","journal-title":"J. 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