{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T08:06:47Z","timestamp":1792829207627,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FirstRand Laurie Dippenaar Scholarship","award":["FS\/4yPhD\/F\/20\/34134"],"award-info":[{"award-number":["FS\/4yPhD\/F\/20\/34134"]}]},{"name":"National Institute for Health Research (NIHR) Biomedical Research Centres at University College London","award":["FS\/4yPhD\/F\/20\/34134"],"award-info":[{"award-number":["FS\/4yPhD\/F\/20\/34134"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation 4-year PhD programme at University College London","doi-asserted-by":"publisher","award":["FS\/4yPhD\/F\/20\/34134"],"award-info":[{"award-number":["FS\/4yPhD\/F\/20\/34134"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Assessment of the right ventricular outflow tract and pulmonary arteries (RVOT) for percutaneous pulmonary valve implantation (PPVI) uses discrete measurements (diameters and lengths) from medical images. This multi-centre study identified the 3D RVOT shape features prevalent in patients late after surgical repair of congenital heart disease (CHD). A 3D RVOT statistical shape model (SSM) was computed from 81 retrospectively selected CHD patients (14.7 \u00b1 6.8 years) who required pulmonary valve replacement late after surgical repair. A principal component analysis identified prevalent shape features (modes) within the population which were compared with standard geometric measurements (diameter, length and surface area) and between sub-groups of diagnosis, RVOT type and dysfunction. Shape mode 1 and 2 represented RVOT size and curvature and tapering and length, respectively. Shape modes 3\u20135 related to branch pulmonary artery calibre, conical vs. bulbous RVOTs and RVOT curvature, respectively. Tetralogy of Fallot, transannular patch type and regurgitant RVOTs were larger and straighter while conduit and stenotic types were longer and more cylindrical than other subgroups. This SSM analysed the main 3D shape features present in a population of RVOTs, exploiting the wide 3D anatomical information provided by routine imaging. This morphological information may have implications for PPVI patient selection and device design.<\/jats:p>","DOI":"10.3390\/jcdd11100330","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T03:49:34Z","timestamp":1729136974000},"page":"330","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A 3D Statistical Shape Model of the Right Ventricular Outflow Tract in Pulmonary Valve Replacement Patients Post-Surgical Repair"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3573-7649","authenticated-orcid":false,"given":"Liam","family":"Swanson","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK"},{"name":"Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1157-1514","authenticated-orcid":false,"given":"Rapha\u00ebl","family":"Sivera","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK"},{"name":"Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Capelli","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK"},{"name":"Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulaziz","family":"Alosaimi","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre, Division of Cardiology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2070-7276","authenticated-orcid":false,"given":"Dariusz","family":"Mroczek","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre, Division of Cardiology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4605-5600","authenticated-orcid":false,"given":"Christopher Z.","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Department of Medical Imaging, University of Toronto, Toronto, ON M5T 1W7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-7546","authenticated-orcid":false,"given":"Andrew","family":"Cook","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK"},{"name":"Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4474-7304","authenticated-orcid":false,"given":"Rajiv R.","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Labatt Family Heart Centre, Division of Cardiology, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada"},{"name":"Department of Paediatrics, University of Toronto, Toronto, ON M5G 1X8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Schievano","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK"},{"name":"Great Ormond Street Hospital for Children, London WC1N 3JH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth Prevalence of Congenital Heart Disease Worldwide: A Systematic Review and Meta-Analysis","volume":"58","author":"Konings","year":"2011","journal-title":"J. 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