{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:19:23Z","timestamp":1791404363713,"version":"4.3.3"},"reference-count":28,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Region of Southern Denmark","award":["1685"],"award-info":[{"award-number":["1685"]}]},{"name":"Region of Southern Denmark","award":["5587"],"award-info":[{"award-number":["5587"]}]},{"DOI":"10.13039\/501100004196","name":"Odense University Hospital","doi-asserted-by":"publisher","award":["1685"],"award-info":[{"award-number":["1685"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004196","name":"Odense University Hospital","doi-asserted-by":"publisher","award":["5587"],"award-info":[{"award-number":["5587"]}],"id":[{"id":"10.13039\/501100004196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Pericoronary adipose tissue attenuation (PCATa), observed from coronary computed tomography angiography (CCTA), is emerging as an inflammation marker. This study evaluated the relationship between PCATa and plaque characteristics, including plaque type, burden, and coronary calcification. An observational study was conducted on 466 patients with suspected chronic coronary syndrome who underwent clinically indicated CCTA. PCATa was measured along the proximal 40 mm of the coronary arteries and averaged to represent the patient\u2019s level. Plaque type was assessed, compositional plaque volumes were measured, and plaque burdens were quantified. The coronary calcification scores (CCSs) were categorized into groups. Statistical methods included t-tests, ANOVA, and multivariate regression analysis. PCATa differed significantly between calcified (\u221281.7 Hounsfield units (HU)) and soft (\u221277.5 HU) plaques. PCATa was positively associated with total plaque burden (\u03b2 = 3.6) and non-calcified plaque burden (\u03b2 = 7.0), but negatively correlated with calcified plaque burden (\u03b2 = \u22123.5), independent of clinical factors and tube voltage (p &lt; 0.05). The effect of PCATa was stronger when plaques of a different composition were absent. No significant differences in PCATa were found among different CCS groups. PCATa increased for calcified compared to soft plaques. The non-calcified plaque burden was associated with a higher PCATa, while the calcified plaque burden was associated with a lower PCATa.<\/jats:p>","DOI":"10.3390\/jcdd11110360","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T04:22:56Z","timestamp":1730953376000},"page":"360","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patient-Level Pericoronary Adipose Tissue Mean Attenuation: Associations with Plaque Characteristics"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4445-8235","authenticated-orcid":false,"given":"Katrine Schultz","family":"Overgaard","sequence":"first","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0251-4489","authenticated-orcid":false,"given":"Thomas Rueskov","family":"Andersen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0003-4801","authenticated-orcid":false,"given":"Roda Abdulkadir","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6019-671X","authenticated-orcid":false,"given":"Sebastian Villesen","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Health Sciences Research Centre, UCL University College, 5230 Odense M, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1525-5316","authenticated-orcid":false,"given":"Helle","family":"Precht","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Health Sciences Research Centre, UCL University College, 5230 Odense M, Denmark"},{"name":"Institute of Regional Health Research, University of Southern Denmark, 5230 Odense M, Denmark"},{"name":"Department of Radiology, Lillebaelt Hospital, University Hospitals of Southern Denmark, 6000 Kolding, Denmark"},{"name":"Discipline of Medical Imaging and Radiation Therapy, University College Cork, T12 K8AF Cork, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9976-9981","authenticated-orcid":false,"given":"Jess","family":"Lambrechtsen","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0399-2503","authenticated-orcid":false,"given":"S\u00f8ren","family":"Auscher","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6214-8751","authenticated-orcid":false,"given":"Kenneth","family":"Egstrup","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Unit, Odense University Hospital Svendborg, 5700 Svendborg, Denmark"},{"name":"Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"ref_1","unstructured":"WHO (2024). The Top 10 Causes of Death, World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"294","DOI":"10.5551\/jat.RV17020","article-title":"Plaque Calcification During Atherosclerosis Progression and Regression","volume":"25","author":"Shioi","year":"2018","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kumric, M., Borovac, J.A., Martinovic, D., Ticinovic Kurir, T., and Bozic, J. (2021). Circulating Biomarkers Reflecting Destabilization Mechanisms of Coronary Artery Plaques: Are We Looking for the Impossible?. Biomolecules, 11.","DOI":"10.3390\/biom11060881"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"eaal2658","DOI":"10.1126\/scitranslmed.aal2658","article-title":"Detecting human coronary inflammation by imaging perivascular fat","volume":"9","author":"Antonopoulos","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2217\/clp.10.89","article-title":"Perivascular adipose tissue and vascular disease","volume":"6","author":"Britton","year":"2011","journal-title":"Clin. Lipidol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.112.001133","article-title":"Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels","volume":"127","author":"Margaritis","year":"2013","journal-title":"Circulation"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/eurheartj\/ehz474","article-title":"Imaging residual inflammatory cardiovascular risk","volume":"41","author":"Antoniades","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1093\/eurheartj\/ehad484","article-title":"Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers: A clinical consensus statement from the European Society of Cardiology Working Group on Coronary Pathophysiology and Micro-circulation","volume":"44","author":"Antoniades","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1093\/ehjci\/jez013","article-title":"Relationship between changes in pericoronary adipose tissue attenuation and coronary plaque burden quantified from coronary computed tomography angiography","volume":"20","author":"Goeller","year":"2019","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(18)31114-0","article-title":"Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): A post-hoc analysis of prospective outcome data","volume":"392","author":"Oikonomou","year":"2018","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"6838","DOI":"10.1007\/s00330-020-07069-0","article-title":"Towards reference values of pericoronary adipose tissue attenuation: Impact of coronary artery and tube voltage in coronary computed tomography angiography","volume":"30","author":"Ma","year":"2020","journal-title":"Eur. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.jcmg.2021.07.011","article-title":"Association of Tube Voltage with Plaque Composition on Coronary CT Angiography: Results From PARADIGM Registry","volume":"14","author":"Takagi","year":"2021","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0735-1097(90)90282-T","article-title":"Quantification of coronary artery calcium using ultrafast computed tomography","volume":"15","author":"Agatston","year":"1990","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s10554-013-0194-x","article-title":"Automatic quantification and characterization of coronary atherosclerosis with computed tomography coronary angiography: Cross-correlation with intravascular ultrasound virtual histology","volume":"29","author":"Broersen","year":"2013","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1161\/01.CIR.51.4.5","article-title":"A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association","volume":"51","author":"Austen","year":"1975","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2018.02.079","article-title":"Coronary Atherosclerotic Precursors of Acute Coronary Syndromes","volume":"71","author":"Chang","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_18","first-page":"E736","article-title":"Determination of total adipose tissue and body fat in women by computed tomography, 40K, and tritium","volume":"250","author":"Kvist","year":"1986","journal-title":"Am. J. Physiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0140-6736(13)61754-7","article-title":"18F-fluoride positron emission tomography for identification of ruptured and high-risk coronary atherosclerotic plaques: A prospective clinical trial","volume":"383","author":"Joshi","year":"2014","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1007\/s00330-021-07882-1","article-title":"Focal pericoronary adipose tissue attenuation is related to plaque presence, plaque type, and stenosis severity in coronary CTA","volume":"31","author":"Ma","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.clinimag.2023.02.009","article-title":"Pericoronary adipose tissue differences among plaque types: A retrospective assessment","volume":"96","author":"Jing","year":"2023","journal-title":"Clin. Imaging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e591","DOI":"10.1016\/j.crad.2023.04.007","article-title":"Correlation of pericoronary adipose tissue CT attenuation values of plaques and periplaques with plaque characteristics","volume":"78","author":"Jing","year":"2023","journal-title":"Clin. Radiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.amjcard.2010.08.034","article-title":"Mortality incidence of patients with non-obstructive coronary artery disease diagnosed by computed tomography angiography","volume":"107","author":"Ahmadi","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jcct.2023.08.008","article-title":"Pericoronary adipose tissue attenuation is associated with non-calcified plaque burden in patients with chronic coronary syndromes","volume":"17","author":"Giesen","year":"2023","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1007\/s00330-022-08781-9","article-title":"A preliminary coronary computed tomography angiography-based study of perivascular fat attenuation index: Relation with epicardial adipose tissue and its distribution over the entire coronary vasculature","volume":"32","author":"Bao","year":"2022","journal-title":"Eur. Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.21037\/qims-23-147","article-title":"Is there an association between coronary artery inflammation and coronary atherosclerotic burden?","volume":"13","author":"Jing","year":"2023","journal-title":"Quant. Imaging Med. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.jcmg.2018.04.015","article-title":"Effects of Statins on Coronary Atherosclerotic Plaques: The PARADIGM Study","volume":"11","author":"Lee","year":"2018","journal-title":"JACC Cardiovasc. 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