{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T08:12:22Z","timestamp":1784967142406,"version":"3.55.0"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T00:00:00Z","timestamp":1732492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health and Social Research Center, the Faculty of Nursing (Albacete) and the CarVasCare Research Group","award":["2023-GRIN-34459"],"award-info":[{"award-number":["2023-GRIN-34459"]}]},{"name":"Health and Social Research Center, the Faculty of Nursing (Albacete) and the CarVasCare Research Group","award":["FPU21\/06866"],"award-info":[{"award-number":["FPU21\/06866"]}]},{"name":"Health and Social Research Center, the Faculty of Nursing (Albacete) and the CarVasCare Research Group","award":["2022-PROD-20657"],"award-info":[{"award-number":["2022-PROD-20657"]}]},{"name":"Ministry of Science, Innovation and University","award":["2023-GRIN-34459"],"award-info":[{"award-number":["2023-GRIN-34459"]}]},{"name":"Ministry of Science, Innovation and University","award":["FPU21\/06866"],"award-info":[{"award-number":["FPU21\/06866"]}]},{"name":"Ministry of Science, Innovation and University","award":["2022-PROD-20657"],"award-info":[{"award-number":["2022-PROD-20657"]}]},{"name":"University of Castilla-La Mancha","award":["2023-GRIN-34459"],"award-info":[{"award-number":["2023-GRIN-34459"]}]},{"name":"University of Castilla-La Mancha","award":["FPU21\/06866"],"award-info":[{"award-number":["FPU21\/06866"]}]},{"name":"University of Castilla-La Mancha","award":["2022-PROD-20657"],"award-info":[{"award-number":["2022-PROD-20657"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Coenzyme Q10 (CoQ10) has been suggested as an adjunct therapy for endocrine and metabolic disorders. The aim of this study was to synthesise the evidence for the effect of CoQ10 supplementation on lipid and\/or glycaemic alterations, including total cholesterol (TC), LDL- and HDL-cholesterol (LDL-C and HDL-C), lipoprotein a, fasting blood glucose (FBG), haemoglobin A1c (HbA1c), fasting insulin and Homeostatic Model Assessment of Insulin Resistance. A systematic search was conducted in Medline, Scopus, Web of Science and the Cochrane Library from their inception to July 2024. Meta-analyses that evaluated the effect of CoQ10 on the lipid or glycaemic profiles were included. Results were expressed as mean difference (MD) or standardised mean difference (SMD). CoQ10 showed an effect on the glycaemic profile, especially on FBG (MD from \u221211.21 to \u22125.2 mg\/dL, SMD from \u22122.04 to \u22120.17) and on HbA1c (MD from \u22121.83 to \u22120.12%, SMD of \u22120.30). CoQ10 may also have an effect on the lipid profile, such as TC, triglycerides, HDL-C and even LDL-C, although the inconsistency of the results was somewhat higher. Supplementation with CoQ10 may be beneficial, especially in populations with diabetes mellitus or other endocrine and metabolic disorders. It could also have some effect on lipid parameters, which, together with the above, may reduce cardiovascular morbidity and mortality, although this is something that needs further research.<\/jats:p>","DOI":"10.3390\/jcdd11120377","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T06:25:19Z","timestamp":1732515919000},"page":"377","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effect of Coenzyme Q10 Supplementation on Lipid and Glycaemic Profiles: An Umbrella Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Silvana","family":"Pati\u00f1o-Cardona","sequence":"first","affiliation":[{"name":"Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-616X","authenticated-orcid":false,"given":"Miriam","family":"Garrido-Miguel","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"},{"name":"Faculty of Nursing, Universidad de Castilla-La Mancha, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-8752","authenticated-orcid":false,"given":"Carlos","family":"Pascual-Morena","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"},{"name":"Faculty of Nursing, Universidad de Castilla-La Mancha, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-8039","authenticated-orcid":false,"given":"Carlos","family":"Berlanga-Mac\u00edas","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"},{"name":"Faculty of Nursing, Universidad de Castilla-La Mancha, 02006 Albacete, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7944-1065","authenticated-orcid":false,"given":"Maribel","family":"Lucer\u00f3n-Lucas-Torres","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-8377","authenticated-orcid":false,"given":"Sof\u00eda","family":"Alfaro-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Health and Social Research Center, Universidad de Castilla-La Mancha, 16071 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-6953","authenticated-orcid":false,"given":"Irene","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"CarVasCare Research Group (2023-GRIN-34459), Facultad de Enfermer\u00eda de Cuenca, Universidad de Castilla-La Mancha, 16001 Cuenca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41569-021-00541-4","article-title":"Global Epidemiology of Dyslipidaemias","volume":"18","author":"Pirillo","year":"2021","journal-title":"Nat. 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