{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:23Z","timestamp":1760146823836,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Academy of Sciences","award":["0419-2024-0002","124041800039-2"],"award-info":[{"award-number":["0419-2024-0002","124041800039-2"]}]},{"DOI":"10.13039\/501100002674","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["0419-2024-0002","124041800039-2"],"award-info":[{"award-number":["0419-2024-0002","124041800039-2"]}],"id":[{"id":"10.13039\/501100002674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The purpose: Evaluation of the short-term and long-term results of a phased correction of the tetralogy of Fallot (ToF) with stenting of the right ventricular outflow tract (RVOT) in comparison with a one-stage total correction (TC) of the defect. Materials and methods: Two groups of patients with classical ToF were formed. Group 1 (n = 25; median age = 72 days) was initially represented by children with ToF with a more severe clinical status (median weight = 3.6 kg, with more pronounced cyanosis and with comorbidities). The children of group 1 underwent the first stage of RVOT stenting and the second stage of TC of ToF. Group 2 (n = 25) was represented by older patients, with a higher body weight and SpO2 level, and they underwent a single-stage TC of the defect. Results: The application of a step-by-step ToF correction approach with RVOT stenting in low-weight newborns with severe hypoxemia demonstrated an equivalent effect on SpO2 dynamics\u2014reverse remodeling of the heart\u2014when compared with a less severe cohort of patients who underwent simultaneous TC of classical ToF. After RVOT stenting in children from group 1, the median SpO2 increased from 80% to 94.5%, the median Z value of the pulmonary artery trunk decreased from \u22123.46 mm to \u22122.54 mm, and the median index of end-diastolic volume of the left ventricle decreased from 23.07 mm\/m2 to 57.6 mL\/m2. TC of ToF in children from group 1 with a phased strategy of correction of the defect was no less successful than in children who underwent simultaneous TC. In the long-term follow-up period after TC of ToF, children from both groups, who were obviously unequal in their initial status, were practically comparable in clinical characteristics, exhibiting features of cardiac remodeling and achieving endpoints. And there were no significant differences between the two groups in the frequency of reaching the endpoints such as re-operations, cerebrovascular events, and death during the annual, three-year, and five-year follow-up period. Conclusions: The strategy of RVOT stenting followed by TC of ToF in a severe group of children demonstrated comparable results compared with the results of simultaneous TC of ToF in a more stable group of patients during the in-hospital, annual, three-year, and five-year follow-up periods.<\/jats:p>","DOI":"10.3390\/jcdd11120398","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T06:44:05Z","timestamp":1733899445000},"page":"398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Five-Year Comparison Results Between Clinically Severely Affected Tetralogy-of-Fallot Patients Initially Treated by Right Ventricular Outflow Stenting and Pink-Fallot Patients Undergoing Single-Step Correction"],"prefix":"10.3390","volume":"11","author":[{"given":"Anton Alexandrovich","family":"Lyapin","sequence":"first","affiliation":[{"name":"Laboratory of X-Ray Endovascular and Reconstructive Cardiovascular Surgery, Department of Cardiovascular Surgery, Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Blvd. Named After Academician L.S. Barbarasha, 6, 650002 Kemerovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina Nikolaevna","family":"Lyapina","sequence":"additional","affiliation":[{"name":"Laboratory of X-Ray Endovascular and Reconstructive Cardiovascular Surgery, Department of Cardiovascular Surgery, Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Blvd. Named After Academician L.S. Barbarasha, 6, 650002 Kemerovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Alexandrovna","family":"Rumiantseva","sequence":"additional","affiliation":[{"name":"Laboratory of X-Ray Endovascular and Reconstructive Cardiovascular Surgery, Department of Cardiovascular Surgery, Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Blvd. Named After Academician L.S. Barbarasha, 6, 650002 Kemerovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-709X","authenticated-orcid":false,"given":"Roman Sergeevich","family":"Tarasov","sequence":"additional","affiliation":[{"name":"Laboratory of X-Ray Endovascular and Reconstructive Cardiovascular Surgery, Department of Cardiovascular Surgery, Federal State Budgetary Institution \u201cResearch Institute for Complex Issues of Cardiovascular Diseases\u201d, Blvd. Named After Academician L.S. Barbarasha, 6, 650002 Kemerovo, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0002-9149(75)90034-X","article-title":"Tetralogy of Fallot: A morphometric and geometric study","volume":"35","author":"Becker","year":"1975","journal-title":"Am. J. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/j.jacc.2011.08.025","article-title":"Birth prevalence of congenital heart disease worldwide: A systematic review and meta-analysis","volume":"58","author":"Konings","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/hrt.77.2.176","article-title":"Right ventricular outflow stent implantation: An alternative to palliative surgical relief of infundibular pulmonary stenosis","volume":"77","author":"Gibbs","year":"1997","journal-title":"Heart"},{"key":"ref_4","first-page":"1985","article-title":"Right ventricular outflow tract stent versus BT shunt palliation in Tetralogy of Fallot","volume":"103","author":"Quandt","year":"2017","journal-title":"Heart"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.echo.2008.02.006","article-title":"Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: An echocardiographic study","volume":"21","author":"Pettersen","year":"2008","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1093\/icvts\/ivx267","article-title":"Influence of staged repair and primary repair on outcomes in patients with complete atrioventricular septal defect and tetralogy of Fallot: A systematic review and meta-analysis","volume":"26","author":"Lenko","year":"2018","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.36660\/abc.20210735","article-title":"Transcatheter Palliation for Tetralogy of Fallot","volume":"117","year":"2021","journal-title":"Arq. Bras. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00246-022-02886-0","article-title":"Palliation Strategy to Achieve Complete Repair in Symptomatic Neonates with Tetralogy of Fallot","volume":"43","author":"Law","year":"2022","journal-title":"Pediatr. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100643","DOI":"10.1016\/j.cpcardiol.2020.100643","article-title":"Clinical Outcome of Right Ventricular Outflow Tract Stenting Versus Blalock-Taussig Shunt in Tetralogy of Fallot: A systematic Review and Meta-Analysis","volume":"46","author":"Ghaderian","year":"2021","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/CIRCULATIONAHA.117.028972","article-title":"Duct Stenting Versus Modified Blalock-Taussig Shunt in Neonates With Duct-Dependent Pulmonary Blood Flow: Associations With Clinical Outcomes in a Multicenter National Study","volume":"137","author":"Bentham","year":"2018","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1161\/CIRCULATIONAHA.117.029987","article-title":"Comparison Between Patent Ductus Arteriosus Stent and Modified Blalock-Taussig Shunt as Palliation for Infants With Ductal-Dependent Pulmonary Blood Flow: Insights From the Congenital Catheterization Research Collaborative","volume":"137","author":"Glatz","year":"2018","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/ccd.29306","article-title":"Short to medium term outcomes of right ventricular outflow tract stenting as initial palliation for symptomatic infants with complete atrioventricular septal defect with associated tetralogy of Fallot","volume":"96","author":"Abumehdi","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"349","DOI":"10.17116\/kardio202114051349","article-title":"Modern data on correction of tetralogy of Fallot","volume":"14","author":"Lyapin","year":"2021","journal-title":"Russ. J. Cardiol. Cardiovasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jocs.14031","article-title":"Two-stage approach for surgical treatment of tetralogy of Fallot in underweight children: Clinical and morphological outcomes","volume":"34","author":"Nokhrin","year":"2019","journal-title":"J. Card. Surg."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/12\/398\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:52:08Z","timestamp":1760115128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/11\/12\/398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,11]]},"references-count":14,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["jcdd11120398"],"URL":"https:\/\/doi.org\/10.3390\/jcdd11120398","relation":{},"ISSN":["2308-3425"],"issn-type":[{"type":"electronic","value":"2308-3425"}],"subject":[],"published":{"date-parts":[[2024,12,11]]}}}