{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T11:10:28Z","timestamp":1759921828579,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:00:00Z","timestamp":1736812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Boston Scientific","award":["RI\/17\/5353"],"award-info":[{"award-number":["RI\/17\/5353"]}]},{"name":"Endotronix","award":["RI\/17\/5353"],"award-info":[{"award-number":["RI\/17\/5353"]}]},{"name":"Medtronic","award":["RI\/17\/5353"],"award-info":[{"award-number":["RI\/17\/5353"]}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["RI\/17\/5353"],"award-info":[{"award-number":["RI\/17\/5353"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Hospitalisation for acute decompensated heart failure (HF) portends a poor prognosis. Fluid retention manifesting in dyspnoea and oedema are important clinical features of decompensated heart failure and drive hospital admissions. Intracardiac and pulmonary artery pressure (PAP) monitoring can help predict heart failure decompensation, as changes in these haemodynamics occur before clinical congestion manifests. Methods: A retrospective single centre analysis of patients who underwent insertion of the Cordella\u2122 PA Sensor System (Endotronix, Inc., Chicago, IL, USA) in University Hospital Galway, Ireland, as part of three separate clinical trials\u2014SIRONA 1, SIRONA 2, PROACTIVE HF, was performed. The primary clinical outcome assessed was the difference between HF hospitalisation pre- and post-sensor implantation. Results: In total, there were 33 patients with symptomatic HF who underwent device insertion between 2018 and 2023. All patients had NYHA class 3 heart failure, and 48.5% (n = 16) of patients had HF with reduced ejection fraction. Only one device-related complication was noted, and no pressure sensor failures occurred. In total, there were 26 admissions for HF decompensation 1-year pre-device insertion and only three admissions post-insertion. The difference in the mean number of HF hospitalisations per patient pre- and post-device insertion was 0.70 (p &lt; 0.0001). The difference in mean NYHA class score pre- and post-insertion was 1.0 (p &lt; 0.001). Conclusions: Data from this single-centre cohort study have shown that the insertion of the Cordella\u2122 PA Sensor System in symptomatic HF patients was safe and resulted in statistically significant improvements in HF hospitalisations and NYHA class.<\/jats:p>","DOI":"10.3390\/jcdd12010025","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T03:29:43Z","timestamp":1736825383000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1069-3851","authenticated-orcid":false,"given":"Niall","family":"Leahy","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, H91YR71 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cillian","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, H91YR71 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Essa","family":"Alsubai","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Galway, University Road, H91TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen","family":"Coen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Galway, University Road, H91TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darragh","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Galway, University Road, H91TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-4864","authenticated-orcid":false,"given":"Faisal","family":"Sharif","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, H91YR71 Galway, Ireland"},{"name":"Department of Medicine, University of Galway, University Road, H91TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.jacc.2023.04.010","article-title":"Remote Monitoring for Heart Failure Management at Home","volume":"81","author":"Stevenson","year":"2023","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1002\/ehf2.13550","article-title":"Patient monitoring across the spectrum of heart failure disease management 10 years after the CHAMPION trial","volume":"8","author":"Abraham","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4330\/wjc.v9.i1.21","article-title":"Ambulatory pulmonary artery pressure monitoring in advanced heart failure patients","volume":"9","author":"Yandrapalli","year":"2017","journal-title":"World J. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"ehy566.P5683","DOI":"10.1093\/eurheartj\/ehy566.P5683","article-title":"P5683Turning the tide of heart failure: The Irish experience in the implication of a modern community outreach programme","volume":"39","author":"Caples","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1002\/ehf2.14698","article-title":"Assessing the impact of haemodynamic monitoring with CardioMEMS on heart failure patients: A cost-benefit analysis","volume":"11","author":"Codina","year":"2024","journal-title":"ESC Heart Fail."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Escobar, C., Varela, L., Palacios, B., Capel, M., Sicras, A., Sicras, A., Hormigo, A., Alc\u00e1zar, R., Manito, N., and Botana, M. (2020). Costs and healthcare utilisation of patients with heart failure in Spain. BMC Health Serv. Res., 20.","DOI":"10.1186\/s12913-020-05828-9"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e003594","DOI":"10.1161\/CIRCHEARTFAILURE.116.003594","article-title":"Intracardiac Pressures Measured Using an Implantable Hemodynamic Monitor","volume":"10","author":"Zile","year":"2017","journal-title":"Circ. Heart Fail."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0140-6736(11)60101-3","article-title":"Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: A randomised controlled trial","volume":"377","author":"Abraham","year":"2011","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/S0140-6736(23)00923-6","article-title":"Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): A randomised clinical trial","volume":"401","author":"Brugts","year":"2023","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_11","first-page":"euad233","article-title":"Remote monitoring of cardiac implantable electronic devices and disease management","volume":"25","author":"Varma","year":"2023","journal-title":"EP Eur."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/CIRCULATIONAHA.110.937409","article-title":"Efficacy and Safety of Automatic Remote Monitoring for Implantable Cardioverter-Defibrillator Follow-Up","volume":"122","author":"Varma","year":"2010","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.1002\/ehf2.14006","article-title":"Safety and efficacy of a wireless pulmonary artery pressure sensor: Primary endpoint results of the SIRONA 2 clinical trial","volume":"9","author":"Sharif","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/ejhf.1870","article-title":"Digital health care solution for proactive heart failure management with the Cordella Heart Failure System: Results of the SIRONA first-in-human study","volume":"22","author":"Mullens","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.jchf.2024.05.017","article-title":"Seated Pulmonary Artery Pressure Monitoring in Patients With Heart Failure: Results of the PROACTIVE-HF Trial","volume":"12","author":"Guichard","year":"2024","journal-title":"JACC Heart Fail."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cardfail.2022.09.006","article-title":"Rationale and Design of the Proactive-HF Trial for Managing Patients With NYHA Class III Heart Failure by Using the Combined Cordella Pulmonary Artery Sensor and the Cordella Heart Failure System","volume":"29","author":"Guichard","year":"2023","journal-title":"J. Card. Fail."},{"key":"ref_17","unstructured":"(2024, March 16). TCTMD.com [Internet]. Remote Management of Sitting Pulmonary Artery Pressures Tested Against a Performance Goal of Reduced HF Hospitalizations and All-Cause Mortality in a Prospective Multi-Center Open Label PROACTIVE-HF Trial in NYHA Class III Heart Failure. Available online: https:\/\/www.tctmd.com\/slide\/remote-management-sitting-pulmonary-artery-pressures-tested-against-performance-goal-reduced."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Tedeschi, A., Palazzini, M., Trimarchi, G., Conti, N., Di Spigno, F., Gentile, P., D\u2019Angelo, L., Garascia, A., Ammirati, E., and Morici, N. (2024). Heart Failure Management through Telehealth: Expanding Care and Connecting Hearts. J. Clin. Med., 13.","DOI":"10.3390\/jcm13092592"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1093\/eurheartj\/ehad346","article-title":"Efficacy of pulmonary artery pressure monitoring in patients with chronic heart failure: A meta-analysis of three randomized controlled trials","volume":"44","author":"Clephas","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1002\/ehf2.14056","article-title":"Ambulatory haemodynamic-guided management reduces heart failure hospitalizations in a multicentre European heart failure cohort","volume":"9","author":"Dauw","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1002\/ejhf.1943","article-title":"Pulmonary artery pressure-guided therapy in ambulatory patients with symptomatic heart failure: The CardioMEMS European Monitoring Study for Heart Failure (MEMS-HF)","volume":"22","author":"Angermann","year":"2020","journal-title":"Eur. J. Heart Fail."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e008335","DOI":"10.1161\/CIRCHEARTFAILURE.121.008335","article-title":"Trends in 30- and 90-Day Readmission Rates for Heart Failure","volume":"14","author":"Khan","year":"2021","journal-title":"Circ. Heart Fail."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cjco.2022.12.008","article-title":"Ambulatory Pulmonary Artery Pressure Monitoring Reduces Costs and Improves Outcomes in Symptomatic Heart Failure: A Single-Centre Canadian Experience","volume":"5","author":"Gibson","year":"2023","journal-title":"CJC Open"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ehf2.13748","article-title":"Real-world evidence in a national health service: Results of the UK CardioMEMS HF System Post-Market Study","volume":"9","author":"Cowie","year":"2022","journal-title":"ESC Heart Fail."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.healthpol.2018.05.006","article-title":"Sl\u00e1intecare\u2014A ten-year plan to achieve universal healthcare in Ireland","volume":"122","author":"Burke","year":"2018","journal-title":"Health Policy"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1753944719870084","DOI":"10.1177\/1753944719870084","article-title":"6-minute walking test: A useful tool in the management of heart failure patients","volume":"13","author":"Giannitsi","year":"2019","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e007956","DOI":"10.1161\/CIRCOUTCOMES.121.007956","article-title":"Improvement in KCCQ-12 Scores after a Self-Care Intervention in Patients with Acute Heart Failure Discharged from the Emergency Department","volume":"14","author":"Stubblefield","year":"2021","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/S0140-6736(22)02076-1","article-title":"Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): A multinational, open-label, randomised, trial","volume":"400","author":"Mebazaa","year":"2022","journal-title":"Lancet"},{"key":"ref_29","first-page":"1875","article-title":"Current status of reimbursement practices for remote monitoring of cardiac implantable electrical devices across Europe","volume":"24","author":"Boriani","year":"2022","journal-title":"EP Eur."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1161\/CIRCHEARTFAILURE.109.923300","article-title":"Chronic ambulatory intracardiac pressures and future heart failure events","volume":"3","author":"Stevenson","year":"2010","journal-title":"Circ. Heart Fail."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Leahy, N., O\u2019Brien, C., Alsubai, S.E., Coen, E., Murphy, D., and Sharif, F. (2024, January 17\u201319). Clinical Characteristics and Out-comes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors. Presented at the Irish Cardiac Society Annual Scientific Meeting, Belfast, Ireland.","DOI":"10.1136\/heartjnl-2024-ICS.64"}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/1\/25\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:28:13Z","timestamp":1759919293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/1\/25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,14]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,1]]}},"alternative-id":["jcdd12010025"],"URL":"https:\/\/doi.org\/10.3390\/jcdd12010025","relation":{},"ISSN":["2308-3425"],"issn-type":[{"type":"electronic","value":"2308-3425"}],"subject":[],"published":{"date-parts":[[2025,1,14]]}}}