{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T13:36:29Z","timestamp":1780925789634,"version":"3.54.1"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CARDIO COVID 19-20 registry was funded by the Centro de Investigaciones Cl\u00ednicas of Fundaci\u00f3n Valle del Lili, Cali, Colombia.","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: An advanced age elevates risk for COVID-19-related cardiovascular complications and mortality. This study analyzes cardiovascular comorbidities and outcomes in hospitalized COVID-19 patients across age groups to assess its impact. Methods: The CARDIO COVID 19-20 registry is a prospective, multicenter cohort study of hospitalized SARS-CoV-2 patients across 44 institutions in 14 Latin American countries. Patients were categorized into four age groups, Group 1: under 40 years, Group 2: 40 to 64 years, Group 3: 65 to 79 years, and Group 4: 80 years or older. Results: A total of 3260 patients were included. A total of 36.8% were women, and key comorbidities included overweight\/obesity (49.7% [G1: 48.9%, G2: 56.3%, G3: 45.6%, G4: 32.7%]), and hypertension (49% [G1: 11.3%, G2: 40.3%, G3: 67.9%, G4: 80.4%]). Primary cardiovascular complications during hospitalization were arrhythmias (9.1% [G1: 3.4%, G2: 6.1%, G3: 14.9%, G4: 12.9%]), and acute heart failure (8.5% [G1: 3.6%, G2: 6.1%, G3: 12.1%, and G4: 15.2%]). In our cohort, 53.5% of the patients were admitted to the intensive care unit (G1: 49.2%, G2: 57%, G3: 55.3%, G4: 38.3%). In-hospital mortality rose significantly in patients aged 65 and older; G3: 334 (34.7%) and G4: 156 (45.6%) (p value: &lt;0.001). Conclusions: In Latin American COVID-19 patients, older age correlates with more comorbidities, cardiovascular complications, and higher in-hospital and 30-day mortality, indicating age as an independent mortality factor.<\/jats:p>","DOI":"10.3390\/jcdd12020041","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:17:52Z","timestamp":1737699472000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular Outcomes in Hospitalized Patients with COVID-19: Does Age Really Matter?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4664-9919","authenticated-orcid":false,"given":"Alex","family":"Sotomayor-Julio","sequence":"first","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Faculty of Health Sciences, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Escalante","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Universidad Icesi, Cali 760031, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yorlany","family":"Rodas-Cortes","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5490-2794","authenticated-orcid":false,"given":"Andrea Alejandra","family":"Arteaga-Tobar","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Valencia","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-4692","authenticated-orcid":false,"given":"Fernando","family":"Wyss","sequence":"additional","affiliation":[{"name":"Cardiology Department, Servicios y Tecnolog\u00eda Cardiovascular de Guatemala S.A.\u2014CARDIOSOLUTIONS, Ciudad de Guatemala 01010, Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-9402","authenticated-orcid":false,"given":"Roger Mart\u00edn","family":"Correa","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Nacional Alberto Sabogal Sologuren, Bellavista 07011, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Oliver","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Nacional Arzobispo Loayza, Lima 15082, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilbert Yabar","family":"Galindo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Nacional Guillermo Almenara Irigoyen, Lima 15033, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mercedes","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Nacional San Rafael, Santa Tecla 1501, El Salvador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra In\u00e9s","family":"Christen","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Presidente Per\u00f3n, Buenos Aires B1872AWK, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Criollo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Regional Arica, Arica y Parinacota 1000875, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Martin","family":"Brunialti","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital San Juan de Dios de la Plata, La Plata B1900, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7330-7674","authenticated-orcid":false,"given":"Carlos Eduardo","family":"Montenegro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Pronto S. Cardiologico de PE. Prof. Luiz Tavares\u2014PROCAPE, Recife 74970-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0706-0933","authenticated-orcid":false,"given":"Pedro","family":"Schwartzmann","sequence":"additional","affiliation":[{"name":"Cardiology Department, CLINICOR\u2014Cl\u00ednica Cardiol\u00f3gica LTDA, Goi\u00e2nia 74075-040, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eglee","family":"Castillo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro Policl\u00ednico Valencia, Valencia 2001, Venezuela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freddy Pow","family":"Chong","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Luis Vernaza, Guayaquil 090313, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7218-8351","authenticated-orcid":false,"given":"Claudia","family":"Almonte","sequence":"additional","affiliation":[{"name":"Cardiology Department, Medicina Cardiovascular Asociada (MCA), Santo Domingo 10602, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Herrera","sequence":"additional","affiliation":[{"name":"Cardiology Department, Centro de Diagn\u00f3stico, Medicina Avanzada y Telemedicina (CEDIMAT), Santo Domingo 10216, Dominican Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6635-6224","authenticated-orcid":false,"given":"Juan Esteban","family":"Gomez-Mesa","sequence":"additional","affiliation":[{"name":"Departamento de Cardiolog\u00eda, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"},{"name":"Faculty of Health Sciences, Universidad Icesi, Cali 760031, Colombia"},{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali 760032, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41586-021-04188-6","article-title":"The emergence, genomic diversity and global spread of SARS-CoV-2","volume":"600","author":"Li","year":"2021","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.35663\/amp.2020.371.909","article-title":"Preparation and control of the coronavirus disease 2019 (COVID-19) in Latin America","volume":"37","author":"Verbanaz","year":"2020","journal-title":"Acta Medica Peru."},{"key":"ref_3","unstructured":"CDC (2022, December 20). 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