{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T07:13:48Z","timestamp":1775632428226,"version":"3.50.1"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Philips Healthcare","award":["SFB-1470\u2014B06"],"award-info":[{"award-number":["SFB-1470\u2014B06"]}]},{"name":"the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)","award":["SFB-1470\u2014B06"],"award-info":[{"award-number":["SFB-1470\u2014B06"]}]},{"name":"the Berlin University Alliance (OX|BER Research Partnership\/Flexible Funds)","award":["SFB-1470\u2014B06"],"award-info":[{"award-number":["SFB-1470\u2014B06"]}]},{"name":"the Kaltenbach doctorate fund of the Deutsche Herzstiftung","award":["SFB-1470\u2014B06"],"award-info":[{"award-number":["SFB-1470\u2014B06"]}]},{"name":"the Charit\u00e9 Universit\u00e4tsmedizin Berlin.","award":["SFB-1470\u2014B06"],"award-info":[{"award-number":["SFB-1470\u2014B06"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: While left-bundle-branch-block-related contraction patterns as well as echocardiography-derived strain are variably associated with the volumetric response to cardiac resynchronization therapy (CRT), the role of CMR-derived strain parameters is unexplored. Methods: A total of 50 patients receiving CRT implantation were retrospectively analyzed, all of whom had undergone CMR imaging within one year before, and echocardiography within 6 months before and 6\u201312 months after CRT implantation. We assessed CMR-derived morphological and functional parameters with regard to the echocardiographic response, defined as a reduction in the left ventricular end-systolic volume of \u226515%. Results: Among the standard CMR parameters, the indexed right ventricular volumes in end-diastole (RVEDVi) (74.5 \u00b1 19.5 vs. 94.8 \u00b1 30.2 mL\/m2, p = 0.006) and end-systole (RVESVi) (43.2 \u00b1 13.3 vs. 61.6 \u00b1 28.8 mL\/m2, p = 0.003), as well as the left atrial (LA) area (24.8 \u00b1 3.5 vs. 30.4 \u00b1 9.5 cm2, p = 0.020), differed significantly between CRT responders and non-responders. In strain analysis, CRT responders showed a significantly better LA global longitudinal strain (GLS) (25.1 \u00b1 10.4 vs. 15.3 \u00b1 10.5, p = 0.002), LA global circumferential strain (GCS) (27.9 \u00b1 14.7 vs. 17.1 \u00b1 13.1%, p = 0.012), RV GLS (\u221225.0 \u00b1 6.5 vs. \u221218.9 \u00b1 7.6%, p = 0.004) and RV free wall strain (\u221231.1 \u00b1 7.9 vs. \u221224.9 \u00b1 9.5, p = 0.017). Conclusions: CMR-derived peak septal circumferential strain and RVEDVi correlated with the echocardiographic volumetric response to CRT at 6\u201312 months.<\/jats:p>","DOI":"10.3390\/jcdd12040152","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:38:26Z","timestamp":1744349906000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Right Ventricular and Left Atrial Strain Predict Volumetric Response to Cardiac Resynchronization Therapy"],"prefix":"10.3390","volume":"12","author":[{"given":"Shing","family":"Ching","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"Division of Cardiology, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4393-5773","authenticated-orcid":false,"given":"Jeffrey Ji-Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie Maria","family":"Werhahn","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9373-0756","authenticated-orcid":false,"given":"Rebecca Elisabeth","family":"Beyer","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misael","family":"Estepa","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Stehning","sequence":"additional","affiliation":[{"name":"Clinical Science, Philips Healthcare, R\u00f6ntgenstra\u00dfe 24, 22335 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djawid","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Solowjowa","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Klein","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1909-4329","authenticated-orcid":false,"given":"Henryk","family":"Dreger","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8105-6599","authenticated-orcid":false,"given":"Sebastian","family":"Kelle","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1511-8015","authenticated-orcid":false,"given":"Patrick","family":"Doeblin","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum der Charit\u00e9\u2013Medical Heart Center of Charit\u00e9 and German Heart Institute, Department of Cardiology, Angiology and Intensive Care Medicine, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Potsdamer Str. 58, 10785 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jacc.2008.10.032","article-title":"Long-Term Prognosis After Cardiac Resynchronization Therapy Is Related to the Extent of Left Ventricular Reverse Remodeling at Midterm Follow-Up","volume":"53","author":"Ypenburg","year":"2009","journal-title":"J. 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