{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:09:14Z","timestamp":1760058554299,"version":"build-2065373602"},"reference-count":13,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Essential thrombocythemia (ET) is a rare myeloproliferative neoplasm characterized by excessive platelet production and a predisposition to thrombotic or hemorrhagic complications. We report a case of a 62-year-old male with no conventional cardiovascular risk factors who presented with a non-ST-segment elevation myocardial infarction (NSTEMI). Initial coronary angiography showed isolated proximal LAD stenosis. Laboratory tests revealed marked thrombocytosis (&gt;1,000,000\/\u03bcL) and a CALR mutation, confirming a diagnosis of ET. The patient was treated with percutaneous coronary intervention (PCI), dual antiplatelet therapy, and cytoreductive therapy with hydroxyurea, leading to a favorable outcome. This case illustrates how ET, particularly CALR-mutated subtypes, can manifest as acute coronary syndrome in the absence of atherosclerosis and underscores the need to consider hematologic malignancies in atypical presentations of myocardial infarction.<\/jats:p>","DOI":"10.3390\/jcdd12040157","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T04:05:31Z","timestamp":1744776331000},"page":"157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-ST-Elevation Myocardial Infarction as the Initial Manifestation of Calreticulin-Positive Essential Thrombocythemia: A Case Report"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7601-5446","authenticated-orcid":false,"given":"Jared B.","family":"Hinton","sequence":"first","affiliation":[{"name":"Department of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6523-2670","authenticated-orcid":false,"given":"Jalal S.","family":"Jwayyed","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonum","family":"Jagetia","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4500-159X","authenticated-orcid":false,"given":"Hunter J.","family":"Landwehr","sequence":"additional","affiliation":[{"name":"Department of Medicine, Northeast Ohio Medical University, Rootstown, OH 44272, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Scrocco","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mercy Health St. Elizabeth Boardman Hospital, Boardman, OH 44512, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"ref_1","unstructured":"Mechanic, O.J., Gavin, M., and Grossman, S.A. (2025, March 30). Acute Myocardial Infarction, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459269\/."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_3","first-page":"e891","article-title":"Contemporary Diagnosis and Management of Patients WITH Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement from the American Heart Association","volume":"139","author":"Jneid","year":"2019","journal-title":"Circulation"},{"key":"ref_4","unstructured":"Michelson, A.D. (2013). Platelets, Academic Press. [3rd ed.]."},{"key":"ref_5","unstructured":"Thapa, B., Fazal, S., Parsi, M., and Rogers, H.J. (2025, January 07). Myeloproliferative Neoplasms, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK531464\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00395-024-01077-7","article-title":"Immuno-related cardio-vascular adverse events associated with immuno-oncological treatments: An under-estimated threat for cancer patients","volume":"120","author":"Panuccio","year":"2025","journal-title":"Basic Res. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1182\/asheducation-2016.1.534","article-title":"Update from the latest WHO classification of MPNs: A user\u2019s manual","volume":"2016","author":"Passamonti","year":"2016","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3324\/haematol.12053","article-title":"Recurrent thrombosis in patients with polycythemia vera and essential thrombocythemia: Incidence, risk factors, and effect of treatments","volume":"93","author":"Za","year":"2008","journal-title":"Haematologica"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1001\/jama.2024.25349","article-title":"Essential Thrombocythemia: A Review","volume":"333","author":"Tefferi","year":"2025","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2634853520978210","DOI":"10.1177\/2634853520978210","article-title":"The Essential Thrombocythemia in 2020: What We Know and Where We Still Have to Dig Deep","volume":"13","author":"Accurso","year":"2020","journal-title":"Clin. Med. Insights Blood Disord."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11239-018-1619-0","article-title":"A rare CALR variant mutation and a review of CALR in essential thrombocythemia","volume":"45","author":"Diep","year":"2018","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"306.e5","DOI":"10.1016\/j.avsg.2017.01.004","article-title":"Medical Management of Extensive Arterial Thromboembolism in a Patient with Essential Thrombocythemia and Warfarin Failure","volume":"42","author":"Ahmed","year":"2017","journal-title":"Ann. Vasc. Surg."},{"key":"ref_13","first-page":"495","article-title":"Myocardial infarction as the first manifestation of essential thrombocythemia","volume":"102","author":"Fioranelli","year":"2005","journal-title":"Int. J. Cardiol."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/4\/157\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:15:18Z","timestamp":1760030118000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/4\/157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["jcdd12040157"],"URL":"https:\/\/doi.org\/10.3390\/jcdd12040157","relation":{},"ISSN":["2308-3425"],"issn-type":[{"type":"electronic","value":"2308-3425"}],"subject":[],"published":{"date-parts":[[2025,4,16]]}}}