{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:27:24Z","timestamp":1788298044709,"version":"build-2803163510"},"reference-count":16,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Bicuspid aortic valve (BAV) and thoracic aortic aneurysms and dissections (TAAD) are recognized in syndromic connective tissue diseases (CTD), but most cases occur sporadically. The extent to which non-syndromic BAV or TAAD predisposes to additional arteriopathies, particularly in younger individuals, remains unclear. We retrospectively analyzed 1438 patients (mean age = 48.0, 67.7% female), excluding those with CTDs. Participants were \u226460 years old and categorized by the presence of BAV and\/or TAAD. We examined co-existing arterial pathologies, including fibromuscular dysplasia, spontaneous coronary artery dissection, abdominal aortic aneurysms (AAA), mesenteric, peripheral extremity, and carotid\/cerebral arteriopathies. Overall, 44.6% had either BAV or TAAD, and 27.2% had multiple arteriopathies. While vascular diseases were frequently noted, odds ratios demonstrated no significantly increased risk of extra-aortic arteriopathies in the BAV or TAAD cohorts. AAA exhibited a non-significant trend toward higher prevalence in TAAD patients. These findings support current guidelines recommending targeted imaging (transthoracic echocardiography of the aortic root and ascending aorta) over comprehensive \u201chead-to-pelvis\u201d screening for non-syndromic BAV or TAAD patients without additional risk factors. Ongoing genetic analyses may elucidate whether particular variants predispose to multi-site aneurysms or dissections. Consequently, targeted surveillance remains appropriate, with broader imaging reserved for patients with genetic or clinical indicators of higher risk.<\/jats:p>","DOI":"10.3390\/jcdd12050167","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:21:56Z","timestamp":1745500916000},"page":"167","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond the Echo: Is Comprehensive Vascular Exploration Valuable in Cases of Non-Syndromic Thoracic Aortic Aneurysms or Bicuspid Aortic Valve?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3787-5988","authenticated-orcid":false,"given":"Austin","family":"Saugstad","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"},{"name":"Department of Cardiovascular Medicine, Creighton University, Phoenix, AZ 85012, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srekar","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9296-2824","authenticated-orcid":false,"given":"George","family":"Bcharah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Firth","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7006-3435","authenticated-orcid":false,"given":"Hend","family":"Bcharah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0940-0168","authenticated-orcid":false,"given":"Hussein","family":"Abdul Nabi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8412-0082","authenticated-orcid":false,"given":"Hoang Nhat","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramzi","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5294-3682","authenticated-orcid":false,"given":"Sant J.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"},{"name":"Department of Cardiovascular Medicine, Creighton University, Phoenix, AZ 85012, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdelnabi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnea M.","family":"Baudhuin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA"},{"name":"Department of Clinical Genomics, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"},{"name":"Department of Clinical Genomics, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayowa A.","family":"Osundiji","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"},{"name":"Department of Clinical Genomics, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Shamoun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ 85054, USA"},{"name":"Department of Clinical Genomics, Mayo Clinic, Phoenix, AZ 85054, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"ref_1","first-page":"e6","article-title":"Heart disease and stroke statistics\u20142013 update: A report from the American Heart 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Surg."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/5\/167\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:21:07Z","timestamp":1760030467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/5\/167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,24]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,5]]}},"alternative-id":["jcdd12050167"],"URL":"https:\/\/doi.org\/10.3390\/jcdd12050167","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,24]]}}}