{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:16:38Z","timestamp":1760058998333,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:00:00Z","timestamp":1747180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: The outcome of patients undergoing transcatheter aortic valve replacement (TAVR) can be affected by coexisting tricuspid regurgitation (TR). The aim of the study is to investigate the clinical results of patients undergoing TAVR with or without concomitant significant TR. Methods: Patients undergoing TAVR were divided into two groups according to TR severity: none\/mild TR (low-grade) and moderate\/severe TR (significant). Data were analysed and compared. Primary endpoint was the mortality 1-year. Secondary endpoints were re-hospitalization and the degree of postoperative and 1-year TR. Results: TAVR procedures were performed in 345 patients between September 2011 and February 2020. Median STS score was 4.3% (IQR: 2.6\u20137.2), median LVEF was 59.0% (IQR: 45.0\u201362.0), median aortic area was 0.70cm2 (IQR: 0.60\u20130.86), median mean gradient was 43.0mmHg (IQR: 36.0\u201353.0). Before TAVR, 297 patients (86.1%) had low-grade TR and 48 (13.9%) significant TR. Mean age was 82.4 \u00b1 5.7 and 83.8 \u00b1 6.2 years in low-grade and significant TR group, respectively (p = 0.109), with 47.5% (low-grade TR) and 56.3% (significant TR) of female patients (p = 0.279). Patients showed differences in EuroSCORE-II (3.2% (IQR: 1.9\u20135.7) in low-grade TR vs. 5.6% (IQR: 3.7\u20138.1) in significant TR; p &lt; 0.001), impaired right ventricular function (3.0% vs. 20.8%; p &lt; 0.001) and pulmonary hypertension (9.1% vs. 39.6%; p &lt; 0.001). Mean valve size was 27.7 \u00b1 2.9 mm. Hospital mortality was 2.0% in low-grade TR and 4.2% in significantTR patients (p = 0.308). Among discharged patients (n = 337), seven patients died within 30 days (2.0% low-grade TR; 2.1% significant TR; logrank test p = 0.154) and 40 were re-hospitalized for heart failure (11.1% low-grade TR; 14.6% significant TR; p = 0.470). After one year, 26 patients died, corresponding to a mortality of 7.9 deaths per 100-person year (95% CI 5.2\u201312.0) in low-grade TR group and 9.1 deaths per 100-person year (95% CI 3.4\u201324.3) in significant TR group (logrank test p = 0.815), with HR (low grade vs. significant TR) of 0.87, 95% CI 0.26\u20132.89. Re-hospitalization for heart failure was 16.5% and 19.6% for low-grade and significant TR, respectively (p = 0.713). Echocardiographic and functional changes over time showed no significant interaction between TR and time. Conclusions: In our experience, patients undergoing TAVR showed similar 30-day and 1-year outcome and re-hospitalization rate, regardless of the degree of concomitant tricuspid regurgitation.<\/jats:p>","DOI":"10.3390\/jcdd12050184","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:22:17Z","timestamp":1747225337000},"page":"184","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One-Year Outcome of Patients Undergoing Transcatheter Aortic Valve Replacement with Concomitant SignificantTricuspid Regurgitation"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2837-3242","authenticated-orcid":false,"given":"Enrico","family":"Ferrari","sequence":"first","affiliation":[{"name":"Cardiac Surgery Unit, Cardiocentro Ticino Institute, EOC, 6900 Lugano, Switzerland"},{"name":"Biomedical Faculty, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland"},{"name":"School of Medicine, University of Zurich, 8006 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1184-7210","authenticated-orcid":false,"given":"Alberto","family":"Pozzoli","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Cardiocentro Ticino Institute, EOC, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0314-8548","authenticated-orcid":false,"given":"Catherine","family":"Klersy","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology & Biostatistics, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9415-7727","authenticated-orcid":false,"given":"Elena","family":"Caporali","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Cardiocentro Ticino Institute, EOC, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3796-1775","authenticated-orcid":false,"given":"Stefanos","family":"Demertzis","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit, Cardiocentro Ticino Institute, EOC, 6900 Lugano, Switzerland"},{"name":"Biomedical Faculty, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pedrazzini","sequence":"additional","affiliation":[{"name":"Biomedical Faculty, Universit\u00e0 della Svizzera Italiana (USI), 6900 Lugano, Switzerland"},{"name":"Cardiology Unit, Cardiocentro Ticino Institute, EOC, 6900 Lugano, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1016\/j.jtcvs.2017.11.108","article-title":"Transcatheter aortic valve replacement in patients with severe mitral or tricuspid regurgitation at extreme risk for surgery","volume":"155","author":"Little","year":"2018","journal-title":"J. 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