{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:43:20Z","timestamp":1793832200969,"version":"4.6.1"},"reference-count":57,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Coronary computed tomography angiography (CCTA) has emerged as the leading noninvasive imaging modality for the assessment of coronary artery disease (CAD), offering high-resolution visualization of the coronary anatomy and plaque characterization. The development of fractional flow reserve derived from CCTA (FFR-CT) has further transformed the diagnostic landscape by enabling the simultaneous evaluation of both anatomical stenosis and lesion-specific ischemia. FFR-CT has demonstrated diagnostic accuracy comparable to invasive FFR. The combined use of CCTA and FFR-CT is now pivotal in a broad range of clinical scenarios, including the evaluation of stable and acute chest pain, assessment of high-risk and complex plaque features, and preoperative planning. As evidence continues to mount, CCTA and FFR-CT are positioned to become the primary gatekeepers to the cardiac catheterization laboratory, potentially reducing the number of unnecessary invasive procedures. This review highlights the growing clinical utility of FFR-CT, its integration with advanced plaque imaging, and the future potential of these technologies in redefining the management of CAD, while also acknowledging current limitations, including image quality requirements, cost, and access.<\/jats:p>","DOI":"10.3390\/jcdd12080279","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T13:35:28Z","timestamp":1753191328000},"page":"279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fractional Flow Reserve from Coronary CT: Evidence, Applications, and Future Directions"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6094-4471","authenticated-orcid":false,"given":"Arta","family":"Kasaeian","sequence":"first","affiliation":[{"name":"Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohadese","family":"Ahmadzade","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Vascular and Interventional Radiology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4496-2191","authenticated-orcid":false,"given":"Taylor","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ghasemi-Rad","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Vascular and Interventional Radiology, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoop Padoor","family":"Ayyappan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Cardiothoracic Imaging, Baylor College of Medicine, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.amepre.2023.11.009","article-title":"Trends in cardiovascular disease mortality rates and excess deaths, 2010\u20132022","volume":"66","author":"Woodruff","year":"2024","journal-title":"Am. J. Prev. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.atherosclerosis.2017.03.027","article-title":"Complex relationship between plaque characteristics and hemodynamic significance of stenosis: Insights from coronary computed tomography angiography imaging","volume":"260","author":"Ferencik","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s40292-021-00497-z","article-title":"Contemporary Management of Stable Coronary Artery Disease","volume":"29","author":"Bertolone","year":"2022","journal-title":"High. Blood Press. Cardiovasc. Prev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.jacc.2008.08.058","article-title":"Diagnostic accuracy of 64-slice computed tomography coronary angiography. a prospective, multicenter, multivendor study","volume":"52","author":"Meijboom","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Writing Committee Members, Gulati, M., Levy, P.D., Mukherjee, D., Amsterdam, E., Bhatt, D.L., Birtcher, K.K., Blankstein, R., Boyd, J., and Bullock-Palmer, R.P. (2021). 2021 AHA\/ACC\/ASE\/CHEST\/SAEM\/SCCT\/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: Executive Summary: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guide-lines. J. Am. Coll. Cardiol., 78, 2218\u20132261.","DOI":"10.1016\/j.jacc.2021.07.052"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1016\/j.jacc.2019.07.085","article-title":"Guiding therapy by coronary CT angiography improves outcomes in patients with stable chest pain","volume":"74","author":"Adamson","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"DISCHARGE Trial Group, Maurovich-Horvat, P., Bosserdt, M., Kofoed, K.F., Rieckmann, N., Benedek, T., Donnelly, P., Rodriguez-Palomares, J., Erglis, A., and \u0160t\u011bchovsk\u00fd, C. (2022). CT or invasive coronary angiography in stable chest pain. N. Engl. J. Med., 386, 1591\u20131602.","DOI":"10.1056\/NEJMoa2200963"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1161\/01.CIR.87.4.1354","article-title":"Experimental basis of determining maximum coronary, myocardial, and collateral blood flow by pressure measurements for assessing functional stenosis severity before and after percutaneous transluminal coronary angioplasty","volume":"87","author":"Pijls","year":"1993","journal-title":"Circulation"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1056\/NEJM199606273342604","article-title":"Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses","volume":"334","author":"Pijls","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jacc.2010.04.012","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention in patients with multivessel coronary artery disease: 2-year follow-up of the FAME (Fractional Flow Reserve versus Angiography for Multivessel Evaluation) study","volume":"56","author":"Pijls","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.117.031907","article-title":"Clinical outcomes and cost-effectiveness of fractional flow reserve-guided percutaneous coronary intervention in patients with stable coronary artery disease: Three-year follow-up of the FAME 2 trial (fractional flow reserve versus angiography for multivessel evaluation)","volume":"137","author":"Fearon","year":"2018","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.amjcard.2015.10.008","article-title":"Comparison of fractional flow reserve based on computational fluid dynamics modeling using coronary angiographic vessel morphology versus invasively measured fractional flow reserve","volume":"117","author":"Achenbach","year":"2016","journal-title":"Am. J. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.jcct.2025.02.004","article-title":"Machine learning and computational fluid dynamics derived FFRCT demonstrate comparable diagnostic performance in patients with coronary artery disease; A Systematic Review and Meta-Analysis","volume":"19","author":"Moradi","year":"2025","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.jacc.2011.06.066","article-title":"Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multi-center DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study","volume":"58","author":"Koo","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1001\/2012.jama.11274","article-title":"Diagnostic accuracy of fractional flow reserve from anatomic CT angiography","volume":"308","author":"Min","year":"2012","journal-title":"JAMA"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jacc.2013.11.043","article-title":"NXT Trial Study Group. Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: The NXT trial (analysis of coronary blood flow using CT angiography: Next steps)","volume":"63","author":"Leipsic","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1001\/jamacardio.2017.2471","article-title":"Comparison of coronary CT angiography, SPECT, PET, and hybrid imaging for diagnosis of ischemic heart disease determined by fractional flow reserve","volume":"2","author":"Danad","year":"2017","journal-title":"JAMA Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1093\/eurheartj\/ehv444","article-title":"Clinical outcomes of fractional flow reserve by computed tomographic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: The prospective longitudinal trial of FFR(CT)\u2014Outcome and resource impacts study","volume":"36","author":"Douglas","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1093\/eurheartj\/ehy530","article-title":"Real-world clinical utility and impact on clinical decision-making of coronary computed tomography angiography-derived fractional flow reserve: Lessons from the ADVANCE Registry","volume":"39","author":"Fairbairn","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e007607","DOI":"10.1161\/CIRCINTERVENTIONS.118.007607","article-title":"Impact of fractional flow reserve derived from coronary computed tomography angiography on heart team treatment decision-making in patients with multivessel coronary artery disease: Insights from the SYNTAX III REVOLUTION trial","volume":"12","author":"Andreini","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_21","first-page":"431","article-title":"Favorable impact of FFRCT on myocardial revascularization outcomes: Results from an observational real-world registry","volume":"15","author":"Lammens","year":"2025","journal-title":"Int. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e034552","DOI":"10.1161\/JAHA.124.034552","article-title":"Agreement of fractional flow reserve estimated by computed tomography with invasively measured fractional flow reserve: A systematic review and meta-analysis","volume":"13","author":"Faulder","year":"2024","journal-title":"J. Am. Heart Assoc."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jcct.2018.10.027","article-title":"Optimized interpretation of fractional flow reserve derived from computed tomography: Comparison of three interpretation methods","volume":"13","author":"Takagi","year":"2019","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jcct.2018.09.003","article-title":"Assessment of lesion-specific ischemia using fractional flow reserve (FFR) profiles derived from coronary computed tomography angiography (FFRCT) and invasive pressure measurements (FFRINV): Importance of the site of measurement and implications for patient referral for invasive coronary angiography and percutaneous coronary interventions","volume":"12","author":"Cami","year":"2018","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.jcmg.2016.11.024","article-title":"Noninvasive FFR derived from coronary CT angiography","volume":"10","author":"Lu","year":"2017","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1007\/s00330-024-10591-0","article-title":"A meta-analysis comparing the diagnostic performance of computed tomography-derived fractional flow reserve and coronary computed tomography angiography at different levels of coronary artery calcium score","volume":"34","author":"Ma","year":"2024","journal-title":"Eur. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jacc.2015.09.051","article-title":"Quality-of-life and economic outcomes of assessing fractional flow reserve with computed tomography angiography","volume":"66","author":"Hlatky","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1093\/eurheartj\/ehab444","article-title":"Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: The FORECAST randomized trial","volume":"42","author":"Curzen","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.jcmg.2020.10.003","article-title":"Role of FFR-CT for the evaluation of patients with anomalous aortic origin of coronary artery","volume":"14","author":"Ferrag","year":"2021","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3348\/kjr.2019.0230","article-title":"Coronary computed tomography angiography-derived fractional flow reserve in patients with anomalous origin of the right coronary artery from the left coronary sinus","volume":"21","author":"Tang","year":"2020","journal-title":"Korean J. Radiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jacc.2015.05.069","article-title":"Plaque characterization by coronary computed tomography angiography and the likelihood of acute coronary events in mid-term follow-up","volume":"66","author":"Motoyama","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcmg.2014.11.002","article-title":"Atherosclerotic plaque characteristics by CT angiography identify coronary lesions that cause ischemia. A direct comparison to fractional flow reserve","volume":"8","author":"Park","year":"2015","journal-title":"J. Am. Coll. Cardiol. Imaging"},{"key":"ref_33","first-page":"e891","article-title":"Contemporary diagnosis and management of patients with myocardial infarction in the absence of obstructive coronary artery disease. A scientific statement from the American Heart Association","volume":"139","author":"Jneid","year":"2019","journal-title":"Circulation"},{"key":"ref_34","first-page":"604","article-title":"Sex- and age-related differences in outcomes of patients with acute myocardial infarction: MINOCA vs. MIOCA","volume":"12","author":"Canton","year":"2023","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1093\/eurheartj\/ehaa503","article-title":"An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European society of cardiology working group on coronary pathophysiology & microcirculation endorsed by coronary vasomotor disorders international study group","volume":"41","author":"Kunadian","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jcct.2017.08.001","article-title":"Effect of the ratio of coronary arterial lumen volume to left ventricle myocardial mass derived from coronary CT angiography on fractional flow reserve","volume":"11","author":"Taylor","year":"2017","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jcct.2017.09.015","article-title":"Coronary lumen volume to myocardial mass ratio in primary microvascular angina","volume":"11","author":"Grover","year":"2017","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jcct.2022.01.004","article-title":"Coronary volume to left ventricular mass ratio in patients with diabetes mellitus","volume":"16","author":"Kuneman","year":"2022","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jcmg.2024.07.018","article-title":"Vascular Remodeling in Coronary Microvascular Dysfunction","volume":"17","author":"Collet","year":"2024","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jcin.2013.05.024","article-title":"A novel noninvasive technology for treatment planning using virtual coronary stenting and computed tomography-derived computed fractional flow reserve","volume":"7","author":"Kim","year":"2014","journal-title":"J. Am. Coll. Cardiol. Interv."},{"key":"ref_41","first-page":"614","article-title":"Non-invasive procedural planning using computed tomography-derived fractional flow reserve","volume":"97","author":"Bom","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jcmg.2022.02.003","article-title":"Clinical validation of a virtual planner for coronary interventions based on coronary CT angiography","volume":"15","author":"Sonck","year":"2022","journal-title":"J. Am. Coll. Cardiol. Imaging"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e007577","DOI":"10.1161\/CIRCINTERVENTIONS.118.007577","article-title":"Predicting the physiological effect of revascularization in serially diseased coronary arteries","volume":"12","author":"Modi","year":"2019","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1016\/j.jcin.2023.08.018","article-title":"Impact of Post-PCI FFR Stratified by Coronary Artery","volume":"16","author":"Collet","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0002-9149(02)02456-6","article-title":"Comparison between visual assessment and quantitative angiography versus fractional flow reserve for native coronary narrowings of moderate severity","volume":"90","author":"Fischer","year":"2002","journal-title":"Am. J. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1016\/j.jacc.2009.11.096","article-title":"Angiographic versus functional severity of coronary artery stenoses in the FAME study fractional flow reserve versus angiography in multivessel evaluation","volume":"55","author":"Tonino","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jtcvs.2013.06.026","article-title":"Fractional flow reserve\u2013guided coronary artery bypass grafting: Can intraoperative physiologic imaging guide decision making? J","volume":"146","author":"Ferguson","year":"2013","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"ref_48","unstructured":"(2017). Fractional flow reserve to guide to assess coronary artery bypass grafting. Eur. Heart J., 38, 1959\u20131968."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.carrev.2021.09.003","article-title":"Successful coronary artery bypass grafting based solely on non-invasive coronary computed tomography angiography","volume":"40","author":"Kawashima","year":"2022","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/icvts\/ivz046","article-title":"Feasibility of planning coronary artery bypass grafting based only on coronary computed tomography angiography and CT-derived fractional flow reserve: A pilot survey of the surgeons involved in the randomized SYNTAX III Revolution trial","volume":"29","author":"Sonck","year":"2019","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12410-017-9412-6","article-title":"The updated NICE guidelines: Cardiac CT as the first-line test for coronary artery disease","volume":"10","author":"Moss","year":"2017","journal-title":"Curr. Cardiovasc. Imaging Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e038152","DOI":"10.1136\/bmjopen-2020-038152","article-title":"Safety and feasibility evaluation of planning and execution of surgical revascularisation solely based on coronary CTA and FFRCT in patients with complex coronary artery disease: Study protocol of the FASTTRACK CABG study","volume":"10","author":"Kawashima","year":"2020","journal-title":"BMJ Open"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1001\/jamacardio.2023.2595","article-title":"Comparison of an initial risk-based testing strategy vs usual testing in stable symptomatic patients with suspected coronary artery disease","volume":"8","author":"Douglas","year":"2023","journal-title":"JAMA Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2967\/jnumed.117.201368","article-title":"Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC","volume":"59","author":"Murthy","year":"2018","journal-title":"J. Nucl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1056\/NEJMoa1716734","article-title":"Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease","volume":"380","author":"Nagel","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa1700445","article-title":"Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI","volume":"376","author":"Davies","year":"2017","journal-title":"N. Engl. J. Med."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/8\/279\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:13:58Z","timestamp":1760033638000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/8\/279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":57,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025,8]]}},"alternative-id":["jcdd12080279"],"URL":"https:\/\/doi.org\/10.3390\/jcdd12080279","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,22]]}}}