{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:13:29Z","timestamp":1787998409737,"version":"build-2784847793"},"reference-count":33,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T00:00:00Z","timestamp":1753920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The objective of the present study was to evaluate the association between liver cirrhosis (LC) and subsequent Heart failure (HF). This retrospective cohort study utilized data from the Disease Analyzer database (IQVIA) and included adults with a first-time diagnosis of LC in 1293 general practices in Germany between January 2005 and December 2023. A comparison cohort without liver diseases was matched to the cirrhosis group using 5:1 propensity score matching. Univariable Cox proportional hazards models were used to assess the association between alcoholic vs. non-alcoholic LC and HF. The final study cohort included 5530 patients with alcoholic LC and 27,650 matched patients without liver disease, as well as 7063 patients with non-alcoholic LC and 35,315 matched patients without liver disease. After up to 10 years of follow-up, HF was diagnosed in 20.9% of patients with alcoholic LC compared to 10.3% of matched cohort, and in 23.0% of patients with non-alcoholic LC, compared to 14.2% in matched cohort. Alcoholic LC (Hazard Ratio (HR): 2.07 (95% CI: 1.85\u20132.31) and non-alcoholic LC (HR: 1.70; 95% CI: 1.56\u20131.82) were associated with an increased risk of HF. The association was also stronger in men than in women. LC, both alcoholic and non-alcoholic, is significantly associated with an increased long-term risk of HF. The association is particularly pronounced in patients with alcoholic cirrhosis and in men. To the best of the authors\u2019 knowledge, this is the first real-world evidence for the positive association between LC and subsequent HF from Europe.<\/jats:p>","DOI":"10.3390\/jcdd12080295","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T13:11:11Z","timestamp":1754313071000},"page":"295","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Both Alcoholic and Non-Alcoholic Liver Cirrhosis Are Associated with an Increased Risk of HF\u2014A Cohort Study Including 75,558 Patients"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2124-7227","authenticated-orcid":false,"given":"Karel","family":"Kostev","sequence":"first","affiliation":[{"name":"IQVIA, Epidemiology, 60549 Frankfurt am Main, Germany"},{"name":"University Hospital, Philipps University of Marburg, 35043 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9107-8063","authenticated-orcid":false,"given":"Jamschid","family":"Sedighi","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Campus Giessen, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2673","authenticated-orcid":false,"given":"Samuel","family":"Sossalla","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Campus Giessen, 35392 Giessen, Germany"},{"name":"Department of Cardiology, Kerckhoff-Clinic, 61231 Bad Nauheim, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, 61231 Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6798-5092","authenticated-orcid":false,"given":"Marcel","family":"Konrad","sequence":"additional","affiliation":[{"name":"Health & Social, FOM University of Applied Sciences for Economics and Management, 60486 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8149-8087","authenticated-orcid":false,"given":"Mark","family":"Luedde","sequence":"additional","affiliation":[{"name":"Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Campus Giessen, 35392 Giessen, Germany"},{"name":"Christian-Albrechts-University of Kiel, 24118 Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jhep.2018.09.014","article-title":"Burden of liver diseases in the world","volume":"70","author":"Asrani","year":"2019","journal-title":"J. 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