{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:52:38Z","timestamp":1792900358914,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Radiation exposure in the cardiac catheterization laboratory remains a critical occupational hazard for interventional cardiologists and staff, contributing to orthopedic injuries, cataracts, and malignancy. In parallel, procedural complexity continues to increase, demanding both precision and safety. Robotic-assisted percutaneous coronary intervention (R-PCI), alongside advanced shielding systems and imaging integration, has emerged as a transformative strategy to minimize radiation and enhance operator ergonomics. Objective: This state-of-the-art review synthesizes the current clinical evidence and technological advances that support a radiation-reduction paradigm in percutaneous coronary intervention (PCI), with a particular focus on the role of R-PCI platforms, procedural modifications, and emerging shielding technologies. Methods: We reviewed published clinical trials, registries, and experimental studies evaluating robotic PCI platforms, contrast and radiation dose metrics, ergonomic implications, procedural efficiency, and radiation shielding systems. Emphasis was given to the integration of CT-based imaging (coronary computed tomography angiography\u2014CCTA, fractional flow reserve computed tomography\u2014FFR-CT) and low-dose acquisition protocols. Results: R-PCI demonstrated technical success rates of 81\u2013100% and clinical success rates up to 100% in both standard and complex lesions, with significant reductions in operator radiation exposure (up to 95%) and procedural ergonomic burden. Advanced shielding technologies offer radiation dose reductions ranging from 86% to nearly 100%, while integration of (CCTA), (FFR-CT), and Artificial Intelligence (AI) -assisted procedural mapping facilitates further fluoroscopy minimization. Robotic workflows, however, remain limited by lack of device compatibility, absence of haptic feedback, and incomplete integration of physiology and imaging tools. Conclusions: R-PCI, in combination with shielding technologies and imaging integration, marks a shift towards safer, radiation-minimizing interventional strategies. This transition reflects not only a technical evolution but a philosophical redefinition of safety, precision, and sustainability in modern interventional cardiology.<\/jats:p>","DOI":"10.3390\/jcdd12090339","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T15:15:57Z","timestamp":1756912557000},"page":"339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Radiation-Free Percutaneous Coronary Intervention: Myth or Reality?"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1785-3198","authenticated-orcid":false,"given":"Sotirios C.","family":"Kotoulas","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-463X","authenticated-orcid":false,"given":"Andreas S.","family":"Triantafyllis","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1402-4682","authenticated-orcid":false,"given":"Nestoras","family":"Kontogiannis","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Tsinivizov","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Antoniades","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibraheem","family":"Aqeel","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Karapedi","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Kolyda","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9525-0971","authenticated-orcid":false,"given":"Leonidas E.","family":"Poulimenos","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Asklepeion General Hospital, 16673 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1093\/eurheartj\/ehw334","article-title":"Cardiovascular disease in Europe: Epidemiological update 2016","volume":"37","author":"Townsend","year":"2016","journal-title":"Eur. 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