{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:45:40Z","timestamp":1760060740699,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01HL121162","R03HL144891"],"award-info":[{"award-number":["K01HL121162","R03HL144891"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bayer Pharmaceutical","award":["K01HL121162","R03HL144891"],"award-info":[{"award-number":["K01HL121162","R03HL144891"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>(1) Objective: The objective was to test the hypothesis that cine MRI-derived radiomic features can detect functional tricuspid regurgitation (FTR) in the context of pulmonary hypertension (PH). (2) Materials and methods: In total, 53 PH patients were retrospectively enrolled. Thirty-three patients had echocardiography-defined mild-to-severe FTR, while the other twenty patients had no or trivial regurgitation. For all participants, 93 radiomic features were extracted from four-chamber cine MRI using a fixed-size region of interest (ROI) located in the right atrium (RA), 0.5\u20131 cm above the tricuspid valve. The levels of radiomic features were averaged over the ventricular systole and compared between patients with and without FTR using t tests. In patients with FTR, radiomic features were related to hemodynamic parameters in the right heart using the Pearson correlation coefficient (r). (3) Results: There were no significant differences in demographic information, right heart catheterization (RHC) results, and most cine MRI-derived cardiac function indices between the two subject groups. Eight of ninety-three radiomic features were significantly different between PH patients with and without FTR. Radiomic features can be used to discriminate two subject groups (AUC = 0.77). In patients with FTR, multiple radiomic features are related to the pressure in the RA, right ventricle (RV), and pressure difference between RA and RV (r: 0.4 to 0.55), p values &lt; 0.05. (4) Conclusion: Cine MRI-derived radiomic features of the cardiac blood pool differ between PH patients with and without FTR. Cine MRI shows promise as a method for assessing FTR in the context of complex cardiovascular diseases (CVDs).<\/jats:p>","DOI":"10.3390\/jcdd12090353","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:51:33Z","timestamp":1757933493000},"page":"353","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cine MRI-Derived Radiomics for the Detection of Functional Tricuspid Regurgitation in Pulmonary Hypertension: A Proof-of-Concept Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-4077","authenticated-orcid":false,"given":"Kai","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Sarnari","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-3608","authenticated-orcid":false,"given":"Daniel Z.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Markl","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Radiology, Northwestern University Feinberg School of Medicine, 737 N Michigan Ave, Ste 1600, Chicago, IL 60611, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1053\/j.semtcvs.2010.05.004","article-title":"The pathogenesis of functional tricuspid regurgitation","volume":"22","author":"Hung","year":"2010","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Forado-Benatar, I., Caravaca-Perez, P., Rodriguez-Espinosa, D., Guzman-Bofarull, J., Cuadrado-Payan, E., Moayedi, Y., Broseta, J.J., and Farrero, M. (2023). Tricuspid regurgitation, right ventricular function, and renal congestion: A cardiorenal triangle. Front. Cardiovasc. Med., 10.","DOI":"10.3389\/fcvm.2023.1255503"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.echo.2017.01.007","article-title":"Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation: A Report from the American Society of Echocardiography Developed in Collaboration with the Society for Cardiovascular Magnetic Resonance","volume":"30","author":"Zoghbi","year":"2017","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jcmg.2018.07.033","article-title":"Imaging Assessment of Tricuspid Regurgitation Severity","volume":"12","author":"Hahn","year":"2019","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1053\/euhj.1997.0825","article-title":"Comparison of the proximal flow convergence method and the jet area method for the assessment of the severity of tricuspid regurgitation","volume":"19","author":"Grossmann","year":"1998","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"P112","DOI":"10.1186\/1532-429X-15-S1-P112","article-title":"Evaluation of cardiac valvular regurgitant lesions by cardiac MRI sequences: Comparison of a four valve semi-quantitative vs. quantitative approach","volume":"15","author":"Reddy","year":"2013","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/jmri.28572","article-title":"Cine MRI-Derived Radiomics Features of the Cardiac Blood Pool: Periodicity, Specificity, and Reproducibility","volume":"58","author":"Lin","year":"2023","journal-title":"J. Magn. Reson. Imaging"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s10554-024-03131-w","article-title":"Radiomics features of the cardiac blood pool to indicate hemodynamic changes in pulmonary hypertension (PH) due to heart failure with preserved ejection fraction (PH-HFpEF)","volume":"40","author":"Lin","year":"2024","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10554-023-03007-5","article-title":"Cine MRI-derived radiomics features indicate hemodynamic changes in the pulmonary artery","volume":"40","author":"Lin","year":"2024","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1801913","DOI":"10.1183\/13993003.01913-2018","article-title":"Haemodynamic definitions and updated clinical classification of pulmonary hypertension","volume":"53","author":"Simonneau","year":"2019","journal-title":"Eur. Respir. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"H1742","DOI":"10.1152\/ajpheart.00478.2003","article-title":"Myocardial density and composition: A basis for calculating intracellular metabolite concentrations","volume":"286","author":"Vinnakota","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1093\/ehjci\/jeac113","article-title":"Cine magnetic resonance imaging detects shorter cardiac rest periods in postcapillary pulmonary hypertension","volume":"24","author":"Lin","year":"2023","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_13","first-page":"243","article-title":"Right Heart Failure in Pulmonary Hypertension","volume":"38","author":"Cassady","year":"2020","journal-title":"Cardiol. Clin."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/10976640600604856","article-title":"Severity of mitral and aortic regurgitation as assessed by cardiovascular magnetic resonance: Optimizing correlation with Doppler echocardiography","volume":"8","author":"Gelfand","year":"2006","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.jacc.2014.12.047","article-title":"Discordance between echocardiography and MRI in the assessment of mitral regurgitation severity: A prospective multicenter trial","volume":"65","author":"Uretsky","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12968-017-0426-7","article-title":"Tricuspid flow and regurgitation in congenital heart disease and pulmonary hypertension: Comparison of 4D flow cardiovascular magnetic resonance and echocardiography","volume":"20","author":"Driessen","year":"2018","journal-title":"J. Cardiovasc. Magn. Reson."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/9\/353\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:45:10Z","timestamp":1760035510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/12\/9\/353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,13]]},"references-count":16,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["jcdd12090353"],"URL":"https:\/\/doi.org\/10.3390\/jcdd12090353","relation":{},"ISSN":["2308-3425"],"issn-type":[{"type":"electronic","value":"2308-3425"}],"subject":[],"published":{"date-parts":[[2025,9,13]]}}}