{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T04:53:32Z","timestamp":1793940812621,"version":"4.8.0"},"reference-count":116,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Fast-track extubation has emerged as a vital component of Enhanced Recovery After Surgery pathways, designed to optimize recovery and resource utilization after cardiac surgery, contrasting with traditional prolonged ventilation. This review explores the evidence supporting fast-track extubation, detailing patient selection criteria based on preoperative risk factors and functional status and outlining perioperative management strategies. It synthesizes findings from various studies, including randomized controlled trials, retrospective studies, and meta-analyses, focusing on intraoperative techniques such as low-dose opioids, neuromuscular blockade reversal, controlled cardiopulmonary bypass duration, judicious inotrope use, and minimal transfusion, alongside structured postoperative protocols emphasizing early sedative weaning and spontaneous breathing trials. Results demonstrate that fast-track extubation decreases intensive care unit stay, reduces costs and ventilator-associated complications, with a safety comparable to conventional care. Prolonged cardiopulmonary bypass time, dependency on inotropes, and intraoperative blood transfusions are identified as critical predictors of fast-track extubation failure. In conclusion, the successful implementation of fast-track extubation protocols requires a collaborative, multidisciplinary approach, proving essential for improving patient outcomes, minimizing complications such as postoperative delirium, and enhancing hospital efficiency in cardiac surgery. Further research should aim to refine patient selection and standardize protocols across healthcare systems.<\/jats:p>","DOI":"10.3390\/jcdd13010006","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T14:27:47Z","timestamp":1766500067000},"page":"6","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Fast-Track Extubation After Cardiac Surgery: A Narrative Review"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-0763","authenticated-orcid":false,"given":"Alexa","family":"Christophides","sequence":"first","affiliation":[{"name":"Office of the Vice President of Medical Affairs, Northwell Mather Hospital, Port Jefferson, NY 11777, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"DiMaria","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6733-0184","authenticated-orcid":false,"given":"Sophia Ann","family":"Jacob","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Feit","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Oster","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-5908","authenticated-orcid":false,"given":"Sergio","family":"Bergese","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E469","DOI":"10.1503\/cmaj.180635","article-title":"Enhanced recovery after surgery: Implementing a new standard of surgical care","volume":"191","author":"Altman","year":"2019","journal-title":"CMAJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.xjon.2022.07.006","article-title":"A 3-hour fast-track extubation protocol for early extubation after cardiac surgery","volume":"12","author":"Helwani","year":"2022","journal-title":"JTCVS Open"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4103\/aca.aca_207_24","article-title":"Frequency of Fast Track Extubation and Factors Affecting its Success in Adult Cardiac Surgery Patients: A Retrospective Analysis","volume":"28","author":"Zahid","year":"2025","journal-title":"Ann. 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