{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:28:32Z","timestamp":1785929312729,"version":"3.56.0"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Introduction. Patent ductus arteriosus (PDA) is the most common cardiac anomaly in preterm newborns and may aggravate respiratory disease. Invasive closure options after failure of medical treatment include surgical ligation (SL) and transcatheter closure (TCC). Reports on side effects of intravenous contrast media are scarce. Methods. In this retrospective single-center study, we compared 35 preterm infants below 1500 g birth weight undergoing SL with 35 matched infants undergoing TCC. Outcomes were procedural success, complications and postprocedural ventilation. Results. Closure success was high in both groups (97% SL vs. 86% TCC, p = 0.106). One SL patient underwent re-operation after accidental clipping of the left pulmonary artery, and eight patients (24%) had endoscopy-diagnosed vocal cord palsy after SL. Six TCC patients had complications that required further action, including device embolization, device failure and one case of late device migration that resulted in aortic arch obstruction requiring intervention, and 4 TCC patients developed necrotizing enterocolitis (NEC)-like disease within 24 h, requiring surgery in one patient. SL was associated with longer duration of mechanical ventilation (24 h vs. 144 h, p &lt; 0.001), as opposed to TCC, and higher rates of bronchopulmonary dysplasia (86% vs. 53%, p = 0.004). Discussion. Both techniques achieve high success but differ in complication profiles. TCC may reduce respiratory morbidity. NEC-like disease (probably linked to intravenous administration of contrast agents) warrants further investigation.<\/jats:p>","DOI":"10.3390\/jcdd13010022","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T17:24:58Z","timestamp":1767201898000},"page":"22","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Complications of Interventional Versus Surgical Closure of Patent Ductus Arteriosus in Very Preterm Infants\u2014A Retrospective Analysis"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6919-0808","authenticated-orcid":false,"given":"Karla","family":"Girke","sequence":"first","affiliation":[{"name":"Department of Neonatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-414X","authenticated-orcid":false,"given":"Christoph","family":"B\u00fchrer","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-4529","authenticated-orcid":false,"given":"Bernd","family":"Opgen-Rhein","sequence":"additional","affiliation":[{"name":"Department of Congenital Heart Disease\u2014Pediatric Cardiology, Deutsches Herzzentrum der Charit\u00e9, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 13353 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Metze","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Czernik","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, 10117 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2025071425","DOI":"10.1542\/peds.2025-071425","article-title":"Patent Ductus Arteriosus in Preterm Infants","volume":"155","author":"Ambalavanan","year":"2025","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Sung, S.I., Chang, Y.S., Kim, J., Choi, J.H., Ahn, S.Y., and Park, W.S. (2019). Natural evolution of ductus arteriosus with noninterventional conservative management in extremely preterm infants born at 23\u201328 weeks of gestation. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212256"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"de Klerk, J.C.A., Engbers, A.G.J., van Beek, F., Flint, R.B., Reiss, I.K.M., V\u00f6ller, S., and Simons, S.H.P. (2020). Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review. Front. Pediatr., 8.","DOI":"10.3389\/fped.2020.00541"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"He, M., Yang, Z., Gan, T., Tang, J., Ran, S., and Zhang, K. (2023). Echocardiographic parameters predicting spontaneous closure of ductus arteriosus in preterm infants. Front. Pediatr., 11.","DOI":"10.3389\/fped.2023.1198936"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e20164258","DOI":"10.1542\/peds.2016-4258","article-title":"Spontaneous Closure of Patent Ductus Arteriosus in Infants = 1500 g","volume":"140","author":"Semberova","year":"2017","journal-title":"Pediatrics"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41390-019-0387-7","article-title":"Understanding the pathobiology in patent ductus arteriosus in prematurity-beyond prostaglandins and oxygen","volume":"86","author":"Hundscheid","year":"2019","journal-title":"Pediatr. Res."},{"key":"ref_7","first-page":"Cd010061","article-title":"Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants","volume":"12","author":"Jasani","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/cpt.2616","article-title":"The Effect of Ibuprofen Exposure and Patient Characteristics on the Closure of the Patent Ductus Arteriosus in Preterm Infants","volume":"112","author":"Engbers","year":"2022","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/jamapediatrics.2025.1025","article-title":"Active Treatment vs Expectant Management of Patent Ductus Arteriosus in Preterm Infants: A Meta-Analysis","volume":"179","author":"Buvaneswarran","year":"2025","journal-title":"JAMA Pediatr."},{"key":"ref_10","first-page":"Cd013278","article-title":"Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants","volume":"6","author":"Mitra","year":"2025","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Laughon, M.M., Thomas, S.M., Watterberg, K.L., Kennedy, K.A., Keszler, M., Ambalavanan, N., Davis, A.S., Slaughter, J.L., Guillet, R., and Colaizy, T.T. (2025). Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants: The PDA Randomized Clinical Trial. JAMA.","DOI":"10.1001\/jama.2025.23330"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"106167","DOI":"10.1016\/j.earlhumdev.2024.106167","article-title":"Effectiveness of repeated pharmacological courses for patent ductus arteriosus in preterm infants","volume":"200","author":"Dani","year":"2025","journal-title":"Early Hum. Dev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1007\/s00246-024-03626-2","article-title":"Perinatal Factors Associated with Successful Pharmacologic Closure of the Patent Ductus Arteriosus in Premature Infants","volume":"46","author":"Sharma","year":"2024","journal-title":"Pediatr. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/s41372-024-02052-9","article-title":"Procedural closure of the patent ductus arteriosus in preterm infants: A clinical practice guideline","volume":"44","author":"Mitra","year":"2024","journal-title":"J. Perinatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.jpedsurg.2022.02.037","article-title":"Outcomes of patent ductus arteriosus ligation in very low birth weight premature infants: A retrospective cohort analysis","volume":"57","author":"Ashfaq","year":"2022","journal-title":"J. Pediatr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13019-016-0539-3","article-title":"Bedside PDA ligation in premature infants less than 28 weeks and 1000 grams","volume":"11","author":"Avsar","year":"2016","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Saini, A., Hamrick, S., Adamson, M., Bhombal, S., Hash, S., Kim, D.W., LeFevre, A.S., Long, J., Mills, M., and Ligon, R.A. (2025). Impact of PDA Closure Methodology on Peri-procedural Opioid Utilization in Preterm Neonates, a Cross-Sectional Review in a Tertiary Pediatric Healthcare System. Pediatr. Cardiol.","DOI":"10.1007\/s00246-025-03855-z"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/ppul.26325","article-title":"Surgical ligation, not transcatheter closure, associated with a higher severity of bronchopulmonary dysplasia in extremely preterm infant intervened for patent ductus arteriosus","volume":"58","author":"Wei","year":"2023","journal-title":"Pediatr. Pulmonol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/chd.12704","article-title":"Percutaneous closure of the patent ductus arteriosus: Opportunities moving forward","volume":"14","author":"Mitchell","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"113716","DOI":"10.1016\/j.jpeds.2023.113716","article-title":"Trends in Procedural Closure of the Patent Ductus Arteriosus among Infants Born at 22 to 30 Weeks\u2019 Gestation","volume":"263","author":"Shah","year":"2023","journal-title":"J. Pediatr."},{"key":"ref_21","first-page":"1266","article-title":"Amplatzer Piccolo Occluder clinical trial for percutaneous closure of the patent ductus arteriosus in patients \u2265700 grams","volume":"96","author":"Sathanandam","year":"2020","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_22","first-page":"217","article-title":"Percutaneous versus surgical closure of patent ductus arteriosus in low-weight premature infants: 10-year experience in a tertiary center","volume":"101","author":"Ball","year":"2024","journal-title":"An. Pediatr. (Engl. Ed.)"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2024065905","DOI":"10.1542\/peds.2024-065905","article-title":"Transcatheter and Surgical Ductus Arteriosus Closure in Very Low Birth Weight Infants: 2018\u20132022","volume":"154","author":"Leahy","year":"2024","journal-title":"Pediatrics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijcard.2020.03.040","article-title":"Improved ventilation in premature babies after transcatheter versus surgical closure of patent ductus arteriosus","volume":"311","author":"Regan","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s41372-024-02019-w","article-title":"Morbidity and neurodevelopmental outcomes at 2 years in preterm infants undergoing percutaneous transcatheter closure vs. surgical ligation of the PDA","volume":"44","author":"Fernandez","year":"2024","journal-title":"J. Perinatol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kaluarachchi, D.C., Chock, V.Y., Do, B.T., Rysavy, M.A., Sankar, M.N., Laughon, M.M., Backes, C.H., Colaizy, T.T., Bell, E.F., and McNamara, P.J. (2025). Comparison of neurodevelopmental outcomes of extremely preterm infants undergoing trans-catheter closure of the patent ductus arteriosus compared to surgical ligation. J. Perinatol.","DOI":"10.1038\/s41372-025-02417-8"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e2513366","DOI":"10.1001\/jamanetworkopen.2025.13366","article-title":"Respiratory Outcomes After Transcatheter vs Surgical Patent Ductus Arteriosus Closure in Preterm Infants","volume":"8","author":"Chock","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s00246-023-03199-6","article-title":"Comparative Effectiveness of Surgical Ligation and Catheter Closure of Patent Ductus Arteriosus in Preterm Infants","volume":"45","author":"Tabb","year":"2023","journal-title":"Pediatr. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jpeds.2020.10.035","article-title":"Percutaneous Closure of Patent Ductus Arteriosus in Infants 1.5 kg or Less: A Meta-Analysis","volume":"230","author":"Bischoff","year":"2021","journal-title":"J. Pediatr."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Aw, T.C., Chan, B., and Singh, Y. (2023). Transport and Anaesthesia Consideration for Transcatheter Patent Ductus Arteriosus Closure in Premature Infants. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10090377"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/chd.12738","article-title":"Anticipatory perioperative management for patent ductus arteriosus surgery: Understanding postligation cardiac syndrome","volume":"14","author":"Giesinger","year":"2019","journal-title":"Congenit. Heart Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"14345","DOI":"10.1038\/s41598-024-64923-7","article-title":"RBC transfusion and necrotizing enterocolitis in very preterm infants: A multicenter observational study","volume":"14","author":"Dang","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"e615","DOI":"10.1016\/S2352-3026(22)00207-1","article-title":"Packed red blood cell transfusion in preterm infants","volume":"9","author":"Bellach","year":"2022","journal-title":"Lancet Haematol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/RLI.0000000000000019","article-title":"Influence of contrast media viscosity and temperature on injection pressure in computed tomographic angiography: A phantom study","volume":"49","author":"Kok","year":"2014","journal-title":"Invest. Radiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.3348\/kjr.2019.0835","article-title":"Incidence and Risk Factors of Nausea and Vomiting after Exposure to Low-Osmolality Iodinated Contrast Media in Children: A Focus on Preparative Fasting","volume":"21","author":"Ha","year":"2020","journal-title":"Korean J. Radiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1007\/s00330-020-07255-0","article-title":"Is fasting still necessary prior to contrast-enhanced computed tomography? A randomized clinical study","volume":"31","author":"Neeman","year":"2021","journal-title":"Eur. Radiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3748\/wjg.v18.i9.999","article-title":"Transient small bowel angioedema due to intravenous iodinated contrast media","volume":"18","author":"Hu","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/RCT.0000000000001520","article-title":"Incidence of Bowel Wall Swelling Induced by Iodine-Contrast Media and Its Association With Gastrointestinal Manifestation","volume":"48","author":"Ishii","year":"2024","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.amjcard.2022.07.013","article-title":"Renal Function After Transcatheter Piccolo Patent Ductus Arteriosus Closure With Contrast Angiography in Extremely Premature Infants","volume":"181","author":"Herron","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197801000-00001","article-title":"Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging","volume":"187","author":"Bell","year":"1978","journal-title":"Ann. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0031-3955(16)34975-6","article-title":"Necrotizing enterocolitis: Treatment based on staging criteria","volume":"33","author":"Walsh","year":"1986","journal-title":"Pediat. Clin. N. Am."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1017\/S1047951123004353","article-title":"Percutaneous closure of patent ductus arteriosus versus surgical treatment in low-birth-weight preterms: A systematic review and meta-analysis","volume":"34","author":"Melchior","year":"2024","journal-title":"Cardiol. Young"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41372-021-01226-z","article-title":"Phenotyping respiratory decompensation following definitive closure of the patent ductus arteriosus in preterm infants","volume":"42","author":"Wheeler","year":"2022","journal-title":"J. Perinatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.jpeds.2009.01.005","article-title":"The role of patent ductus arteriosus ligation in bronchopulmonary dysplasia: Reexamining a randomized controlled trial","volume":"154","author":"Clyman","year":"2009","journal-title":"J. Pediatr."},{"key":"ref_45","first-page":"934","article-title":"Mobile bedside ductus arteriosus closure in severely premature neonates using only echocardiographic guidance","volume":"103","author":"Georgiev","year":"2024","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E1573403X338573","DOI":"10.2174\/011573403X338573241101092849","article-title":"Safety and Efficacy of Zero Fluoroscopy Patent Ductus Arteriosus Closure in Comparison to the Standardized Fluoroscopy-Guided Procedure: A Systematic Review and Meta-Analysis","volume":"21","author":"Mendel","year":"2025","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4357017","DOI":"10.1155\/2020\/4357017","article-title":"Transcatheter Closure of Patent Ductus Arteriosus under Echocardiography Guidance: A Randomized Controlled Noninferiority Trial","volume":"2020","author":"Wang","year":"2020","journal-title":"J. Interv. Cardiol."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/13\/1\/22\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T05:29:03Z","timestamp":1767677343000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/13\/1\/22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,31]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["jcdd13010022"],"URL":"https:\/\/doi.org\/10.3390\/jcdd13010022","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,31]]}}}