{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:55:52Z","timestamp":1772808952826,"version":"3.50.1"},"reference-count":27,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tianjin Key Medical Discipline (Specialty) Construction Project, Tianjin, China","award":["TJYXZDXK-010A"],"award-info":[{"award-number":["TJYXZDXK-010A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: The prevalence of chronic total occlusion (CTO) lesions is as high as 30% in patients undergoing coronary angiography (CAG). Some CTO patients do not undergo revascularization due to procedural complexity and high risks. This study aimed to investigate the value of cadmium-zinc-telluride (CZT) SPECT dynamic myocardial perfusion imaging (MPI) for risk stratification and prognosis assessment in patients with coronary CTO. Methods: This study retrospectively included 62 patients who underwent CZT SPECT dynamic MPI examination and were diagnosed with CTO by angiography. The primary endpoint was major adverse cardiovascular events (MACEs), defined as cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, hospitalization for heart failure, late coronary revascularization, or hospitalization for unstable angina. Results: Over a median follow-up of 17 months (IQR 11\u201323), 15 MACEs occurred. The stress myocardial blood flow (sMBF) and coronary flow reserve (CFR) in the CTO territory were significantly lower in the MACEs group compared to the non-MACEs group (all p &lt; 0.05). Receiver operating characteristic analysis determined the optimal cut-off values for predicting MACEs as sMBF &lt; 0.75 (sensitivity 78.7%, specificity 73.3%, AUC = 0.74, p &lt; 0.05) and CFR &lt; 1.39 (sensitivity 70.2%, specificity 80.0%, AUC = 0.75, p &lt; 0.01). Kaplan\u2013Meier survival analysis showed that patients with impaired sMBF (p &lt; 0.001) or impaired CFR (p &lt; 0.01), defined by these cut-off values, had significantly worse clinical outcomes. Conclusions: The results of this study indicate that sMBF and CFR obtained from CZT SPECT dynamic MPI provide valuable prognostic prediction for patients with coronary CTO lesions, offering critical evidence for identifying high-risk patients requiring active intervention.<\/jats:p>","DOI":"10.3390\/jcdd13030118","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:17:31Z","timestamp":1772641051000},"page":"118","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Cadmium-Zinc-Telluride Dedicated Cardiac SPECT Dynamic Myocardial Perfusion Quantitative Imaging in Patients with Coronary Chronic Total Occlusion: A Pilot Study"],"prefix":"10.3390","volume":"13","author":[{"given":"Linlin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Tianjin 300060, China"},{"name":"Key Laboratory of Cancer Immunology and Biotherapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekun","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, TEDA International Cardiovascular Hospital, No. 61, 3rd Street, Binhai New Area, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2585-4753","authenticated-orcid":false,"given":"Jianming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, TEDA International Cardiovascular Hospital, No. 61, 3rd Street, Binhai New Area, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wengui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Tianjin 300060, China"},{"name":"Key Laboratory of Cancer Immunology and Biotherapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1093\/eurheartj\/ehy220","article-title":"A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions","volume":"39","author":"Werner","year":"2018","journal-title":"Eur. 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