{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:57:09Z","timestamp":1774454229300,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy of Timi\u0219oara\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t              https:\/\/ror.org\/00afdp487"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Severe aortic stenosis (AS) increases left ventricular afterload and disrupts ventricular\u2013vascular coupling. Transcatheter aortic valve replacement (TAVR) promptly relieves valvular obstruction, but its immediate effects on blood pressure-dependent arterial load and ventricular\u2013vascular interactions are not fully clarified. Estimated pulse wave velocity (ePWV), derived from age and mean arterial pressure, is a convenient surrogate of global arterial load. The study aimed to assess ePWV before and after TAVR and its relationship with ventricular function and inflammatory biomarkers. Methods: In this retrospective observational study, 100 elderly patients with severe AS undergoing TAVR underwent detailed clinical, laboratory, and echocardiographic assessments before and after the procedure. Arterial stiffness was quantified using ePWV, while left ventricular geometry and systolic function were evaluated by standard echocardiography. Post-procedural reassessment was performed at hospital discharge (median 8 days after TAVR). Results: TAVR led to a modest but significant reduction in ePWV (from 12.79 \u00b1 1.54 to 12.39 \u00b1 1.54 m\/s, p &lt; 0.01) and improvement in left ventricular ejection fraction (LVEF) (from 44.89 \u00b1 9.2% to 46.7 \u00b1 7.95%, p &lt; 0.01). Higher baseline ePWV correlated with unfavorable left ventricular remodeling and systolic dysfunction, and post-procedural ePWV remained linked to right ventricular performance. Before TAVR, ePWV and LVEF were both associated with inflammatory biomarkers, relationships that disappeared after intervention. Conclusions: Overall, ePWV functioned as an integrated measure of ventricular\u2013vascular interaction and global hemodynamic load, though its interpretation post-TAVR requires caution due to direct blood pressure dependence and confounding by acute procedural inflammation.<\/jats:p>","DOI":"10.3390\/jcdd13040149","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:05:33Z","timestamp":1774451133000},"page":"149","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Estimated Pulse Wave Velocity as a Marker of Blood-Pressure-Dependent Arterial Load and Ventricular\u2013Vascular Interaction in Severe Aortic Stenosis Before and After Transcatheter Aortic Valve Replacement"],"prefix":"10.3390","volume":"13","author":[{"given":"Simina Mariana","family":"Moroz","sequence":"first","affiliation":[{"name":"Center for Advanced Research in Cardiovascular Pathology and Hemostaseology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-744X","authenticated-orcid":false,"given":"Alina Gabriela","family":"Negru","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"},{"name":"Research Center of the Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirela","family":"Baba","sequence":"additional","affiliation":[{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0859-2498","authenticated-orcid":false,"given":"Silvia","family":"Luca","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"},{"name":"Research Center of the Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihaela","family":"Valcovici","sequence":"additional","affiliation":[{"name":"Cardiology Department, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"},{"name":"Research Center of the Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Maria","family":"Lupu","sequence":"additional","affiliation":[{"name":"Discipline of Parasitology, Department of Infectious Diseases, Center for Diagnosis and Study of Parasitic Diseases, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Clinical Laboratory, Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3752-2122","authenticated-orcid":false,"given":"Darius","family":"Buriman","sequence":"additional","affiliation":[{"name":"Doctoral School Medicine-Pharmacy, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Functional Sciences-Pathophysiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel-Dumitru","family":"Ni\u0219ulescu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"},{"name":"Research Center of the Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"},{"name":"Department of Histology, Faculty of Medicine, \u201cVasile Goldi\u0219\u201d Western University of Arad, 310025 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0600-1103","authenticated-orcid":false,"given":"Ana","family":"Lascu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases Timi\u0219oara, 300310 Timi\u0219oara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Functional Sciences-Pathophysiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Florin","family":"Lighezan","sequence":"additional","affiliation":[{"name":"Center for Advanced Research in Cardiovascular Pathology and Hemostaseology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Internal Medicine I-Medical Semiotics I, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6353-7698","authenticated-orcid":false,"given":"Ioana","family":"Mozos","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Systems Medicine, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Functional Sciences-Pathophysiology, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref_1","first-page":"e72","article-title":"2020 ACC\/AHA Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice 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