{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T16:07:07Z","timestamp":1774973227331,"version":"3.50.1"},"reference-count":146,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Cardiogenic shock is a life-threatening condition caused by the heart\u2019s sudden inability to pump sufficient blood to maintain adequate tissue perfusion, most commonly occurring following a myocardial infarction or acute decompensated heart failure. The resultant hypoperfusion can quickly progress to end-organ failure and ultimately death if not treated urgently. This review explores the management of cardiogenic shock, highlighting current treatments, their effectiveness, and the challenges faced by healthcare providers. It looks at both pharmacological therapies and devices used for cardiac support, including mechanical circulatory support and emergency revascularisation procedures to restore blood flow. We also examine how different stages of shock affect survival and how new technologies including artificial intelligence and wearable monitors could help detect and treat this condition earlier. In addition, this review discusses the significant pressure that cardiogenic shock places on healthcare provision, including the typical financial cost of treatment in the UK, resource utilisation and regional disparities. Finally, we outline future directions for trial design, better prevention, more rapid diagnosis and improved treatments that could improve morbidity and mortality.<\/jats:p>","DOI":"10.3390\/jcdd13040156","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T13:23:17Z","timestamp":1774963397000},"page":"156","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiogenic Shock: Clinical Management, Outcomes and Future Directions"],"prefix":"10.3390","volume":"13","author":[{"given":"Aaqil Ahmad","family":"Aubdool","sequence":"first","affiliation":[{"name":"Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AD, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8556-0530","authenticated-orcid":false,"given":"Andrew J.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St. Bartholomew\u2019s Hospital, London EC1A 7BE, UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London E1 4NS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1441-0417","authenticated-orcid":false,"given":"Daniel A.","family":"Jones","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St. Bartholomew\u2019s Hospital, London EC1A 7BE, UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London E1 4NS, UK"},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St. Bartholomew\u2019s Hospital, London EC1A 7BE, UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London E1 4NS, UK"},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair","family":"Proudfoot","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St. Bartholomew\u2019s Hospital, London EC1A 7BE, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-5055","authenticated-orcid":false,"given":"Krishnaraj S.","family":"Rathod","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St. Bartholomew\u2019s Hospital, London EC1A 7BE, UK"},{"name":"Centre for Cardiovascular Medicine and Devices, William Harvey Research Institute, Queen Mary University of London, London E1 4NS, UK"},{"name":"NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,31]]},"reference":[{"key":"ref_1","first-page":"183","article-title":"Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: A document of the Acute Cardiovascular Care Association of the European Society of Cardiology","volume":"9","author":"Zeymer","year":"2020","journal-title":"Eur. 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