{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:50:19Z","timestamp":1782294619251,"version":"3.54.5"},"reference-count":168,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Beijing Key Laboratory of Multi-modal Intelligent Diagnosis and Treatment for Cardiovascular Diseases in the Whole Life Cycle","award":["BZ-2025-181"],"award-info":[{"award-number":["BZ-2025-181"]}]},{"name":"Beijing Lab for Cardiovascular Precision Medicine","award":["PXM2018_014226_000013"],"award-info":[{"award-number":["PXM2018_014226_000013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, accounting for a substantial proportion of global deaths. Increasing evidence indicates that cardiovascular susceptibility is shaped during fetal development, where the intrauterine environment plays a critical role. Maternal\u2013fetal crosstalk, mediated largely through placental function, coordinates the transfer of metabolic, endocrine, and immune signals that are essential for normal cardiac and vascular development. Disruptions in maternal physiology\u2014including metabolic disorders, hypertensive conditions, inflammation, and environmental stress\u2014can perturb this communication network and alter the intrauterine milieu. These changes induce persistent modifications in cardiomyocyte growth, endothelial function, and key regulatory pathways, thereby contributing to long-term cardiovascular risk. Emerging studies highlight that cardiovascular programming is governed by interconnected mechanisms involving epigenetic regulation, mitochondrial function, immune signaling, and intercellular communication. This review synthesizes current evidence on how maternal\u2013fetal crosstalk shapes cardiovascular development beyond genetic determinants and provides an integrated framework linking early-life exposures to lifelong cardiovascular health.<\/jats:p>","DOI":"10.3390\/jcdd13070292","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:57:24Z","timestamp":1782287844000},"page":"292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal\u2013Fetal Crosstalk in Cardiovascular Programming: Linking the Intrauterine Environment to Lifelong Disease Risk"],"prefix":"10.3390","volume":"13","author":[{"given":"Ning","family":"Wu","sequence":"first","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairui","family":"Sun","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Fan","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yi","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Liu","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihua","family":"He","sequence":"additional","affiliation":[{"name":"Echocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China"},{"name":"Maternal-Fetal Medicine Center in Fetal Heart Disease, Beijing Anzhen Hospital, Beijing 100029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,24]]},"reference":[{"key":"ref_1","unstructured":"(2025). 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