{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T10:44:54Z","timestamp":1785926694125,"version":"3.56.0"},"reference-count":81,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Dev. Dis.","JCDD"],"abstract":"<jats:p>Autoimmune diseases substantially increase the risk of atrial and ventricular arrhythmias and sudden cardiac death through shared immune-mediated mechanisms. Pro-inflammatory cytokines, autoantibodies, and progressive myocardial fibrosis disrupt ion channel function, impair conduction, and create re-entrant substrates. Across systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and systemic sclerosis (SSc), these pathways manifest as atrial fibrillation, ventricular arrhythmias, conduction disease, and heightened arrhythmic mortality. Anti Ro\/SSA antibodies, in particular, contribute to QT prolongation and atrioventricular (AV) block, while cytokines such as TNF \u03b1, IL 1\u03b2, and IL 6 remodel electrophysiological properties and promote fibrosis. Advanced cardiac imaging, especially cardiac magnetic resonance (CMR), detects inflammation and fibrosis even when ejection fraction is preserved, enabling earlier intervention. Management requires a dual approach: standard arrhythmia therapies alongside aggressive control of systemic inflammation with disease-specific immunosuppression. Despite growing evidence, major gaps remain, including the absence of randomized trials targeting immune-driven arrhythmias and the need for integrated risk models incorporating inflammatory biomarkers.<\/jats:p>","DOI":"10.3390\/jcdd13070343","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:39Z","timestamp":1784712039000},"page":"343","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Arrhythmias in Autoimmune Diseases: Immune-Mediated Mechanisms and Management"],"prefix":"10.3390","volume":"13","author":[{"given":"Kamala","family":"Tamirisa","sequence":"first","affiliation":[{"name":"Division of Cardiology, UT Southwestern Medical Center, Dallas, TX 75390, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6394-2543","authenticated-orcid":false,"given":"Jorge","family":"Irizarry-Caro","sequence":"additional","affiliation":[{"name":"Division of Cardiology, UT San Antonio, San Antonio, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4511-3142","authenticated-orcid":false,"given":"Ian","family":"Curnutt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kansas City University College of Osteopathic Medicine, Joplin, MO 64804, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2414-5450","authenticated-orcid":false,"given":"Devika","family":"Adusumilli","sequence":"additional","affiliation":[{"name":"Medical City Fort Worth, Fort Worth, TX 76104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia","family":"Jose","sequence":"additional","affiliation":[{"name":"Senior High School, Carroll ISD, Southlake, TX 76092, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8460-2751","authenticated-orcid":false,"given":"Meenakshi","family":"Jolly","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Torbey","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Brown University Medical Center, Providence, RI 02914, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9918-0878","authenticated-orcid":false,"given":"Annabelle","family":"Volgman","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Rush University Medical Center, Chicago, IL 60612, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"ref_1","first-page":"100267","article-title":"Chronic rheumatologic disorders and cardiovascular disease risk in women","volume":"27","author":"Mehta","year":"2023","journal-title":"Am. 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