{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:10:19Z","timestamp":1790071819801,"version":"4.0.1"},"reference-count":39,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Cardiovasc. Dev. Dis.","JCDD"],"abstract":"<jats:p>Background: For infants who underwent surgical coarctation repair and required balloon angioplasty for recoarctation within the first year of life, data are limited\u2014especially regarding safety, mid-term efficacy, and reintervention risk factors. Methods: This retrospective study included the data of 33 infants who underwent surgical correction of CoA within their first three months of life and whose first cardiac catheterization for recoarctation\u2014defined by a systolic echocardiographic gradient of \u226520 mmHg\u2014was performed within the first year of life. Results: The median age at repair was 21 days, and that at angioplasty was 77 days. The peak systolic gradient decreased from 40.0 to 21.0 mmHg (p &lt; 0.001), and the mean gradient decreased from 13.9 to 6.7 mmHg (p = 0.02). The aortic stenotic diameter increased from 3.2 to 4.1 mm (p &lt; 0.001), and the z score increased from \u22124.2 to \u22122.7 (p &lt; 0.001). Right arm systolic blood pressure dropped from 111.8 to 88.2 mmHg (p &lt; 0.001); 7% of cases remained hypertensive. Complications occurred in 12% of patients, and reintervention was needed in 39.4%. Association with other congenital heart disease increased reintervention risk (OR 4.51). Follow-up gradients were as follows: 27.4 \u00b1 10.2 mmHg (1 year), 24.6 \u00b1 8.3 mmHg (2 years), 32.8 \u00b1 18.8 mmHg (5 years), and 35.4 \u00b1 23.2 mmHg (7 years). Conclusions: Early balloon angioplasty for postoperative recoarctation is safe, effective, and repeatable, with a high procedural success rate and sustained hemodynamic improvements. Reinterventions were more common in patients with additional CHD, though outcomes remained favorable.<\/jats:p>","DOI":"10.3390\/jcdd13090473","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:04:17Z","timestamp":1790067857000},"page":"473","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Balloon Angioplasty for Recoarctation in Infants with Isolated Aortic Coarctation and Coarctation Associated with Other Congenital Heart Diseases"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1147-2359","authenticated-orcid":false,"given":"Axel","family":"Rentzsch","sequence":"first","affiliation":[{"name":"Clinic for Pediatric Cardiology, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"given":"Sophie","family":"Schubert","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Clinic Donaustadt, 1220 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1673-6285","authenticated-orcid":false,"given":"Jochen","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Cardiology, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Migdat","family":"Mustafi","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Hashim","family":"Abdul-Khaliq","sequence":"additional","affiliation":[{"name":"Clinic for Pediatric Cardiology, Saarland University Hospital, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Raza, S., Aggarwal, S., Jenkins, P., Kharabish, A., Anwer, S., Cullington, D., Jones, J., Dua, J., Papaioannou, V., and Ashrafi, R. (2023). Coarctation of the Aorta: Diagnosis and Management. Diagnostics, 13.","DOI":"10.3390\/diagnostics13132189"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jtcvs.2009.04.046","article-title":"Coarctation repair in neonates and young infants: Is small size or low weight still a risk factor?","volume":"138","author":"Burch","year":"2009","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_3","first-page":"168","article-title":"Long-Term Outcomes of Native Coarctation of the Aorta after Balloon Angioplasty or Surgical Aortoplasty in Newborns and Young Infants Less Than 3 Months of Age","volume":"29","author":"Chiu","year":"2013","journal-title":"Acta Cardiol. Sin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.athoracsur.2009.08.035","article-title":"Coarctation of the aorta: Midterm outcomes of resection with extended end-to-end anastomosis","volume":"88","author":"Kaushal","year":"2009","journal-title":"Ann. Thorac. Surg."},{"key":"ref_5","first-page":"1116","article-title":"A prospective observational multicenter study of balloon angioplasty for the treatment of native and recurrent coarctation of the aorta","volume":"83","author":"Harris","year":"2014","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"E009399","DOI":"10.1161\/CIRCINTERVENTIONS.120.009399","article-title":"Percutaneous Implantation of Adult Sized Stents for Coarctation of the Aorta in Children <\/= 20 kg: A 12-Year Experience","volume":"14","author":"Boe","year":"2021","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ijcard.2018.02.054","article-title":"Balloon-expandable stents for recoarctation of the aorta in small children. Two centre experience","volume":"263","author":"Gendera","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_8","first-page":"553","article-title":"Stenting of aortic coarctation: Acute, intermediate, and long-term results of a prospective multi-institutional registry\u2014Congenital Cardiovascular Interventional Study Consortium (CCISC)","volume":"76","author":"Holzer","year":"2010","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00246-014-0909-3","article-title":"Percutaneous angioplasty used to manage native and recurrent coarctation of the aorta in infants younger than 1 year: Immediate and midterm results","volume":"35","author":"Adjagba","year":"2014","journal-title":"Pediatr. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1161\/CIR.0b013e31821b1f10","article-title":"Indications for cardiac catheterization and intervention in pediatric cardiac disease: A scientific statement from the American Heart Association","volume":"123","author":"Feltes","year":"2011","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.acvd.2017.05.007","article-title":"Immediate and midterm results of balloon angioplasty for recurrent aortic coarctation in children aged < 1 year","volume":"111","author":"Lefort","year":"2018","journal-title":"Arch. Cardiovasc. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.echo.2008.02.006","article-title":"Regression equations for calculation of z scores of cardiac structures in a large cohort of healthy infants, children, and adolescents: An echocardiographic study","volume":"21","author":"Pettersen","year":"2008","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e20171904","DOI":"10.1542\/peds.2017-1904","article-title":"Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents","volume":"140","author":"Flynn","year":"2017","journal-title":"Pediatrics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0735-1097(99)00527-6","article-title":"Balloon angioplasty of postsurgical recoarctation in infants: The risk of restenosis and long-term follow-up","volume":"35","author":"Maheshwari","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1093\/eurheartj\/ehn251","article-title":"Long-term (up to 20 years) results of percutaneous balloon angioplasty of recurrent aortic coarctation without use of stents","volume":"29","author":"Reich","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0002-9149(97)00805-9","article-title":"Long-term follow-up results of balloon angioplasty of postoperative aortic recoarctation","volume":"81","author":"Siblini","year":"1998","journal-title":"AM. J. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1017\/S104795110200080X","article-title":"Age-related aspects of balloon angioplasty for postsurgical aortic recoarctation","volume":"12","author":"Agnoletti","year":"2002","journal-title":"Cardiol. Young"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/0735-1097(94)00437-U","article-title":"Balloon angioplasty of native coarctation of the aorta: Midterm follow-up and prognostic factors","volume":"25","author":"Fletcher","year":"1995","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0735-1097(97)00228-3","article-title":"Balloon angioplasty for recurrent coarctation of the aorta: A 12-year review","volume":"30","author":"Yetman","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12576-016-0512-x","article-title":"Pathology and molecular mechanisms of coarctation of the aorta and its association with the ductus arteriosus","volume":"67","author":"Yokoyama","year":"2017","journal-title":"J. Physiol. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/hrt.49.4.317","article-title":"Localised coarctation of the aorta. An age dependent spectrum","volume":"49","author":"Elzenga","year":"1983","journal-title":"Br. Heart J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ijcard.2009.05.036","article-title":"Abnormally extended ductal tissue into the aorta is indicated by similar histopathology and shared apoptosis in patients with coarctation","volume":"145","author":"Kim","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"ref_23","first-page":"120","article-title":"Early and mid-term results with the Growth Stent\u2014A possible concept for transcatheter treatment of aortic coarctation from infancy to adulthood by stent implantation?","volume":"71","author":"Ewert","year":"2008","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/21501351221099933","article-title":"Surgical Treatment Following Stent Angioplasty for High-Risk Neonates With Critical Coarctation of the Aorta","volume":"13","author":"Grieshaber","year":"2022","journal-title":"World J. Pediatr. Congenit. Heart Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e21","DOI":"10.1055\/s-0042-1757175","article-title":"German Registry for Cardiac Operations and Interventions in Patients with Congenital Heart Disease: Report 2021 and 9 Years\u2019 Longitudinal Observations on Fallot and Coarctation Patients","volume":"70","author":"Dittrich","year":"2022","journal-title":"Thorac. Cardiovasc. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1007\/s00246-023-03402-8","article-title":"Medium-Term Outcomes of Stent Therapy for Aortic Coarctation in Children Under 30 kg with New Generation Low-Profile Stents: A Follow-Up Study of a Single Centre Experience","volume":"45","author":"Gibb","year":"2024","journal-title":"Pediatr. Cardiol."},{"key":"ref_27","first-page":"e714","article-title":"ACC\/AHA 2008 Guidelines for the Management of Adults with Congenital Heart Disease: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease)","volume":"118","author":"Warnes","year":"2008","journal-title":"Circulation"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Gendera, K., Meng, Z., Schaeffer, T., Kienmoser, D., Palm, J., Lemmen, T., Ruda, C., Matsubara, M., Heinisch, P.P., and Piber, N. (2026). Outcomes after primary surgical repair of coarctation of the aorta through lateral thoracotomy. Rev. Esp. Cardiol. (Engl. Ed.), in press.","DOI":"10.1016\/j.rec.2026.06.012"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.ejcts.2010.09.048","article-title":"Comparison of surgical and interventional therapy of native and recurrent aortic coarctation regarding different age groups during childhood","volume":"39","author":"Fruh","year":"2011","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0002-9149(90)91390-R","article-title":"Balloon angioplasty for aortic recoarctation: Results of Valvuloplasty and Angioplasty of Congenital Anomalies Registry","volume":"65","author":"Hellenbrand","year":"1990","journal-title":"AM. J. Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.CIR.68.1.109","article-title":"Balloon dilation angioplasty of aortic coarctations in infants and children","volume":"68","author":"Lock","year":"1983","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.jpedsurg.2018.11.012","article-title":"Necrotizing Enterocolitis Associated with Congenital Heart Disease: A Different Entity?","volume":"54","author":"Bubberman","year":"2019","journal-title":"J. Pediatr. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1542\/peds.2006-2640","article-title":"Persistent diastolic flow reversal in abdominal aortic Doppler-flow profiles is associated with an increased risk of necrotizing enterocolitis in term infants with congenital heart disease","volume":"119","author":"Carlo","year":"2007","journal-title":"Pediatrics"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.ijcard.2012.09.084","article-title":"Hypertension after repair of aortic coarctation\u2014A systematic review","volume":"167","author":"Canniffe","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1016\/S0735-1097(03)00480-7","article-title":"Ambulatory blood pressure, left ventricular mass, and conduit artery function late after successful repair of coarctation of the aorta","volume":"41","author":"Pilla","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00246-010-9860-0","article-title":"Underrecognition of elevated blood pressure readings in children after early repair of coarctation of the aorta","volume":"32","author":"Gillett","year":"2011","journal-title":"Pediatr. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/heart.88.2.163","article-title":"Prevalence of hypertension in children after early repair of coarctation of the aorta: A cohort study using casual and 24 h blood pressure measurement","volume":"88","author":"Derrick","year":"2002","journal-title":"Heart"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s00246-008-9280-6","article-title":"Impaired elastic properties of the ascending aorta persist within the first 3 years after neonatal coarctation repair","volume":"30","author":"Kuhn","year":"2009","journal-title":"Pediatr. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"3269","DOI":"10.1161\/CIRCULATIONAHA.104.529792","article-title":"Impaired elastic properties of the ascending aorta in newborns before and early after successful coarctation repair: Proof of a systemic vascular disease of the prestenotic arteries?","volume":"111","author":"Vogt","year":"2005","journal-title":"Circulation"}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/13\/9\/473\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:52:35Z","timestamp":1790070755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/13\/9\/473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcdd13090473"],"URL":"https:\/\/doi.org\/10.3390\/jcdd13090473","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]}}}