{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:16:58Z","timestamp":1775240218726,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007104","name":"Trakya \u00dcniversitesi","doi-asserted-by":"publisher","award":["TUBAP 2016\/81"],"award-info":[{"award-number":["TUBAP 2016\/81"]}],"id":[{"id":"10.13039\/501100007104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Calcific aortic valve disease (CAVD) is a multifactorial condition. Both environmental and genetic factors play an important role in its etiology. CAVD exhibits a broad spectrum, varying from mild valve thickening to severe valve calcification and stenosis. Progression of the disease consists of chronic inflammation, lipoprotein deposition, and active leaflet calcification. It is a process similar to coronary artery disease. In this study, we investigated Lp(a) levels and gene polymorphisms associated with calcific aortic stenosis from blood samples after echocardiography in the evaluation of 75 patients diagnosed with CAVD and 77 controls. Blood tests were run in our laboratory to rule out certain risk factors before echocardiography examination. A significant association among smoking, elevated LDL level and creatinine, low albumin levels, Lp(a) level, rs10455872, and rs3798220 polymorphisms may be considered genetic risk factors for the development of calcific aortic stenosis.<\/jats:p>","DOI":"10.3390\/jcdd6030031","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T10:54:53Z","timestamp":1566816893000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lipoprotein(a) Gene Polymorphism Increases a Risk Factor for Aortic Valve Calcification"],"prefix":"10.3390","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7552-7654","authenticated-orcid":false,"given":"Ugur","family":"Ozkan","sequence":"first","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"},{"name":"Department of Cardiology, Edirne Sultan 1. Murat State Hospital, 22030 Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Ozcelik","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Budak","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey"},{"name":"Molecular Research Lab, Prof. Mirko Tos Ear and Hearing Research Center, Trakya University, 22030 Edirne, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1161\/CIRCULATIONAHA.104.486738","article-title":"Spectrum of calcific aortic valve disease: Pathogenesis, disease progression, and treatment strategies","volume":"111","author":"Freeman","year":"2005","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nrcardio.2010.202","article-title":"Epidemiology of valvular heart disease in the adult","volume":"8","author":"Iung","year":"2011","journal-title":"Nat. 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