{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T14:14:48Z","timestamp":1777644888475,"version":"3.51.4"},"reference-count":30,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Atrial septal defect (ASD) is a non-physiologic communication between the two atria, allowing the shunt between systemic and pulmonary circulation. Data about ASD prevalence among congenital heart disease patients (CHD) in Vietnam are still scarce. We aim to assess the trends in the prevalence of ASD patients and associated factors among CHD patients. This was a cross-sectional study, with data collected from medical records from 1220 CHD patients in Da Nang hospital from 1 January 2010 to 31 December 2015. Descriptive statistics were used to estimate the prevalence of ASD among CHD patients. Comparative statistical methods were used to compare groups and logistic regression to access associated factors with ASD. The overall prevalence of ASD among CHD patients was 18.5% between 2010 and 2015. The prevalence varied between periods, ranging between 15% and 31.9% during the period. The prevalence of ASD women among CHD (25.9%) was significantly higher than for men (16.0%). The prevalence of ASD increased gradually when the age group increased. The factors associated with increased ASD prevalence were being a female and being in an older age group. The findings suggest that targeted policy should provide more-specific health-care services of ASD for women and older patients.<\/jats:p>","DOI":"10.3390\/jcdd7010002","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:42:47Z","timestamp":1577446967000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Trends in the Prevalence of Atrial Septal Defect and Its Associated Factors among Congenital Heart Disease Patients in Vietnam"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2721-8424","authenticated-orcid":false,"given":"Ho","family":"Xuan Tuan","sequence":"first","affiliation":[{"name":"Center for International Health, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80539 Munich, Germany"},{"name":"School of Medicine and Pharmacy, Da Nang University, Da Nang 550000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan","family":"The Phuoc Long","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, Da Nang University, Da Nang 550000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4333-8912","authenticated-orcid":false,"given":"Vu","family":"Duy Kien","sequence":"additional","affiliation":[{"name":"OnCare Medical Technology Company Limited, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-0577","authenticated-orcid":false,"given":"Le","family":"Manh Cuong","sequence":"additional","affiliation":[{"name":"National Hospital of Traditional Medicine, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Van Son","sequence":"additional","affiliation":[{"name":"Phu Tho Provincial General Hospital, Viet Tri 290000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dalla-Pozza","sequence":"additional","affiliation":[{"name":"Center for International Health, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen, 80539 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/MDER.S49368","article-title":"Current perspectives in percutaneous atrial septal defect closure devices","volume":"8","author":"Bissessor","year":"2015","journal-title":"Med. Devices"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.12688\/f1000research.11844.1","article-title":"Recent advances in managing septal defects: Atrial septal defects","volume":"6","author":"Rao","year":"2017","journal-title":"F1000 Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11886-018-0983-x","article-title":"ASD Closure in Structural Heart Disease","volume":"20","author":"Wiktor","year":"2018","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.carpath.2010.02.006","article-title":"Anatomical and pathophysiological classification of congenital heart disease","volume":"19","author":"Thiene","year":"2010","journal-title":"Cardiovasc. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00246-013-0705-5","article-title":"Prevalence of treatment, risk factors, and management of atrial septal defects in a pediatric Medicaid cohort","volume":"34","author":"Shuler","year":"2013","journal-title":"Pediatr. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1016\/S0140-6736(13)62145-5","article-title":"Atrial septal defects","volume":"383","author":"Geva","year":"2014","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s12471-015-0663-z","article-title":"Secundum atrial septal defect in adults: A practical review and recent developments","volume":"23","author":"Kuijpers","year":"2015","journal-title":"Neth. Heart J."},{"key":"ref_8","first-page":"427","article-title":"Adult Congenital Interventions in Heart Failure","volume":"6","author":"Suradi","year":"2017","journal-title":"Interv. Cardiol. Clin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/eurheartj\/ehx687","article-title":"Long-term mortality in patients with atrial septal defect: A nationwide cohort-study","volume":"39","author":"Nyboe","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.1161\/CIRCULATIONAHA.116.023544","article-title":"Trends in Congenital Heart Disease: The Next Decade","volume":"133","author":"Triedman","year":"2016","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijcard.2016.02.133","article-title":"Cause of death in adults with congenital heart disease\u2014An analysis of the German National Register for Congenital Heart Defects","volume":"211","author":"Engelings","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Pei, L., Kang, Y., Zhao, Y., and Yan, H. (2017). Prevalence and risk factors of congenital heart defects among live births: A population-based cross-sectional survey in Shaanxi province, Northwestern China. BMC Pediatr., 17.","DOI":"10.1186\/s12887-017-0784-1"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.5830\/CVJA-2013-028","article-title":"The global burden of congenital heart disease","volume":"24","author":"Hoffman","year":"2013","journal-title":"Cardiovasc. J. Afr."},{"key":"ref_14","first-page":"446","article-title":"Totally Endoscopic Cardiac Surgery for Atrial Septal Defect Repair on Beating Heart Without Robotic Assistance in 25 Patients","volume":"12","author":"Dang","year":"2017","journal-title":"Innovations"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1540-8183.2012.00755.x","article-title":"Safety and long-term outcome of modified intracardiac echocardiography-assisted \u201cno-balloon\u201d sizing technique for transcatheter closure of ostium secundum atrial septal defect","volume":"25","author":"Rigatelli","year":"2012","journal-title":"J. Interv. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1111\/j.1747-0803.2011.00567.x","article-title":"Five-year follow-up of intracardiac echocardiography-assisted transcatheter closure of complex ostium secundum atrial septal defect","volume":"7","author":"Rigatelli","year":"2012","journal-title":"Congenit. Heart Dis."},{"key":"ref_17","unstructured":"Pezzella, A.T. (2017). On Location\u2014Vietnam. CTSNet Inc."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Liu, Y., Chen, S., Zuhlke, L., Black, G.C., Choy, M.K., Li, N., and Keavney, B.D. (2019). Global birth prevalence of congenital heart defects 1970\u20132017: Updated systematic review and meta-analysis of 260 studies. Int. J. Epidemiol.","DOI":"10.1093\/ije\/dyz009"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/ped.13156","article-title":"Congenital heart disease at Laos Children\u2019s Hospital: Two year experience","volume":"59","author":"Hwang","year":"2017","journal-title":"Pediatr. Int."},{"key":"ref_20","first-page":"7","article-title":"Prevalence and echocardiographic characteristics of common congenital heart disease in adult patients at Siriraj Hospital: 10-year study","volume":"98","author":"Ratanasit","year":"2015","journal-title":"J. Med. Assoc. Thai"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1017\/S1047951111000552","article-title":"Adult congenital cardiac surgery in Indonesia","volume":"21","author":"Wilamarta","year":"2011","journal-title":"Cardiol. Young"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/chd.12220","article-title":"Epidemiology of Congenital Heart Disease in India","volume":"10","author":"Bhardwaj","year":"2015","journal-title":"Congenit. Heart Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00380-011-0122-8","article-title":"Effects of age on hemodynamic changes after transcatheter closure of atrial septal defect: Importance of ventricular diastolic function","volume":"27","author":"Masutani","year":"2012","journal-title":"Heart Vessel."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ahj.2017.07.019","article-title":"Regional variation in quality of life in patients with a Fontan circulation: A multinational perspective","volume":"193","author":"Fogleman","year":"2017","journal-title":"Am. Heart J."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ahj.2017.10.018","article-title":"Variation in practice patterns in device closure of atrial septal defects and patent ductus arteriosus: An analysis of data from the IMproving Pediatric and Adult Congenital Treatment (IMPACT) registry","volume":"196","author":"Kennedy","year":"2018","journal-title":"Am. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1017\/S1047951111000618","article-title":"Geography or pathology? Regional variation in atrial septal defect closure rates and techniques","volume":"21","author":"Walker","year":"2011","journal-title":"Cardiol. Young"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.5090\/kjtcs.2017.50.2.78","article-title":"Risk Analysis of the Long-Term Outcomes of the Surgical Closure of Secundum Atrial Septal Defects","volume":"50","author":"Kim","year":"2017","journal-title":"Korean J. Thorac. Cardiovasc. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.ijcard.2007.04.044","article-title":"Repaired and open atrial septal defects type II in adulthood: An epidemiological study of a large European cohort","volume":"126","author":"Engelfriet","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/aogs.12062","article-title":"Birth outcomes of cases with isolated atrial septal defect type II\u2014A population-based case-control study","volume":"92","author":"Vereczkey","year":"2013","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"S2945","DOI":"10.21037\/jtd.2017.10.130","article-title":"Pregnancy in adults with repaired\/unrepaired atrial septal defect","volume":"10","author":"Bredy","year":"2018","journal-title":"J. Thorac. Dis."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/7\/1\/2\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:46:12Z","timestamp":1760190372000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/7\/1\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,27]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,3]]}},"alternative-id":["jcdd7010002"],"URL":"https:\/\/doi.org\/10.3390\/jcdd7010002","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,27]]}}}