{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:20:46Z","timestamp":1760239246606,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The \u201cideal\u201d management of asymptomatic severe mitral regurgitation (MR) in valve prolapse (MVP) is still debated. The aims of this study were to identify pre-operatory parameters predictive of residual MR and of early and long-term favorable remodeling after MVP repair. We included 295 patients who underwent MV repair for MVP with pre-operatory two- and three-dimensional transthoracic echocardiography (2DTTE and 3DTTE) and 6-months (6M) and 3-years (3Y) follow-up 2DTTE. MVP was classified by 3DTTE as simple or complex and surgical procedures as simple or complex. Pre-operative echo parameters were compared to post-operative values at 6M and 3Y. Patients were divided into Group 1 (6M-MR &lt; 2) and Group 2 (6M-MR \u2265 2), and predictors of MR \u2265 2 were investigated. MVP was simple in 178\/295 pts, and 94% underwent simple procedures, while in only 42\/117 (36%) of complex MVP a simple procedure was performed. A significant relation among prolapse anatomy, surgical procedures and residual MR was found. Post-operative MR \u2265 2 was present in 9.8%: complex MVP undergoing complex procedures had twice the percentage of MR \u2265 2 vs. simple MVP and simple procedures. MVP complexity resulted independent predictor of 6M-MR \u2265 2. Favorable cardiac remodeling, initially found in all cases, was maintained only in MR &lt; 2 at 3Y. Pre-operative 3DTTE MVP morphology identifies pts undergoing simple or complex procedures predicting MR recurrence and favorable cardiac remodeling.<\/jats:p>","DOI":"10.3390\/jcdd7040046","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T09:28:23Z","timestamp":1603186103000},"page":"46","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Predictive Value of Pre-Operative 2D and 3D Transthoracic Echocardiography in Patients Undergoing Mitral Valve Repair: Long Term Follow Up of Mitral Valve Regurgitation Recurrence and Heart Chamber Remodeling"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-9644","authenticated-orcid":false,"given":"Gloria","family":"Tamborini","sequence":"first","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Mantegazza","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-6112","authenticated-orcid":false,"given":"Marco","family":"Penso","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Muratori","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0309-6231","authenticated-orcid":false,"given":"Laura","family":"Fusini","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Ghulam Ali","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Cefal\u00f9","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianpiero","family":"Italiano","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Volpato","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Gripari","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1770-6486","authenticated-orcid":false,"given":"Enrico G.","family":"Caiani","sequence":"additional","affiliation":[{"name":"Department of Electronics, Information and Bioengineering, Politecnico di Milano, 20133 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Zanobini","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Pepi","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1159","DOI":"10.1161\/CIR.0000000000000503","article-title":"2017 AHA\/ACC Focused Update of the 2014 AHA\/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","volume":"135","author":"Nishimura","year":"2017","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jama.2013.8643","article-title":"Association Between Early Surgical Intervention vs Watchful Waiting and Outcomes for Mitral Regurgitation Due to Flail Mitral Valve Leaflets","volume":"310","author":"Suri","year":"2013","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jtcvs.2018.02.102","article-title":"Simple versus complex degenerative mitral valve disease","volume":"156","author":"Javadikasgari","year":"2018","journal-title":"J. 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