{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:27:46Z","timestamp":1792495666071,"version":"4.5.0"},"reference-count":108,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The adult human heart cannot repair itself after injury and, instead, forms a permanent fibrotic scar that impairs cardiac function and can lead to incurable heart failure. The zebrafish, amongst other organisms, has been extensively studied for its innate capacity to repair its heart after injury. Understanding the signals that govern successful regeneration in models such as the zebrafish will lead to the development of effective therapies that can stimulate endogenous repair in humans. To date, many studies have investigated cardiac regeneration using a reverse genetics candidate gene approach. However, this approach is limited in its ability to unbiasedly identify novel genes and signalling pathways that are essential to successful regeneration. In contrast, drawing comparisons between different models of regeneration enables unbiased screens to be performed, identifying signals that have not previously been linked to regeneration. Here, we will review in detail what has been learnt from the comparative approach, highlighting the techniques used and how these studies have influenced the field. We will also discuss what further comparisons would enhance our knowledge of successful regeneration and scarring. Finally, we focus on the Astyanax mexicanus, an intraspecies comparative fish model that holds great promise for revealing the secrets of the regenerating heart.<\/jats:p>","DOI":"10.3390\/jcdd8010004","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T05:17:34Z","timestamp":1610947054000},"page":"4","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Unlocking the Secrets of the Regenerating Fish Heart: Comparing Regenerative Models to Shed Light on Successful Regeneration"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-7823","authenticated-orcid":false,"given":"Helen G.","family":"Potts","sequence":"first","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Stockdale","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6624-3038","authenticated-orcid":false,"given":"Mathilda T. M.","family":"Mommersteeg","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1136\/bmj.316.7141.1337","article-title":"ISIS-2: 10 year survival among patients with suspected acute myocardial infarction in randomised comparison of intravenous streptokinase, oral aspirin, both, or neither","volume":"316","author":"Baigent","year":"1998","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1056\/NEJM197907123010201","article-title":"Nonoperative Dilatation of Coronary-Artery Stenosis","volume":"301","author":"Senning","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.21037\/jtd.2018.02.43","article-title":"Fifty years of coronary artery bypass grafting","volume":"10","author":"Melly","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"ref_4","unstructured":"British Heart Foundation (2020). UK Factsheet. Br. Heart Found., 1\u201321. Available online: https:\/\/www.bhf.org.uk\/what-we-do\/our-research\/heart-statistics."},{"key":"ref_5","first-page":"e9349","article-title":"Global Epidemiology of Ischemic Heart Disease: Results from the Global Burden of Disease Study","volume":"12","author":"Khan","year":"2020","journal-title":"Cureus"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.carpath.2015.02.004","article-title":"The winding road to regenerating the human heart","volume":"Volume 24","author":"Gerbin","year":"2015","journal-title":"Cardiovascular Pathology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1161\/CIRCRESAHA.116.303577","article-title":"The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis","volume":"119","author":"Prabhu","year":"2016","journal-title":"Circ. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart Regeneration in Zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient Regenerative Potential of the Neonatal Mouse Heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Price, E.L., Vieira, J.M., and Riley, P.R. (2019). Model organisms at the heart of regeneration. DMM Dis. Models Mech., dmm040691.","DOI":"10.1242\/dmm.040691"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"16012","DOI":"10.1038\/npjregenmed.2016.12","article-title":"Evolution, comparative biology and ontogeny of vertebrate heart regeneration","volume":"1","author":"Vivien","year":"2016","journal-title":"NPJ Regen. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/nrd.2017.106","article-title":"Heart regeneration and repair after myocardial infarction: Translational opportunities for novel therapeutics","volume":"16","author":"Cahill","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.devcel.2016.01.018","article-title":"Mechanisms of Cardiac Regeneration","volume":"36","author":"Uygur","year":"2016","journal-title":"Dev. Cell"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/CIRCRESAHA.117.312586","article-title":"Mechanisms of Cardiac Repair and Regeneration","volume":"122","author":"Broughton","year":"2018","journal-title":"Circ. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.scr.2014.06.003","article-title":"A neonatal blueprint for cardiac regeneration","volume":"13","author":"Porrello","year":"2014","journal-title":"Stem Cell Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/reg2.83","article-title":"Zebrafish heart regeneration: 15 years of discoveries","volume":"4","author":"Burns","year":"2017","journal-title":"Regeneration"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1534\/genetics.114.173849","article-title":"The Genomic and Genetic Toolbox of the Teleost Medaka (Oryzias latipes)","volume":"199","author":"Kirchmaier","year":"2015","journal-title":"Genetics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/dvdy.24154","article-title":"Differential reparative phenotypes between zebrafish and medaka after cardiac injury","volume":"243","author":"Ito","year":"2014","journal-title":"Dev. Dyn."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e25605","DOI":"10.7554\/eLife.25605","article-title":"Reciprocal analyses in zebrafish and medaka reveal that harnessing the immune response promotes cardiac regeneration","volume":"6","author":"Lai","year":"2017","journal-title":"ELife"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/cvr\/cvz221","article-title":"Specific macrophage populations promote both cardiac scar deposition and subsequent resolution in adult zebrafish","volume":"116","author":"Bevan","year":"2020","journal-title":"Cardiovasc. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.devcel.2017.11.010","article-title":"Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs","volume":"43","author":"Hui","year":"2017","journal-title":"Dev. Cell"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.fsi.2019.09.030","article-title":"Prolonged neutrophil retention in the wound impairs zebrafish heart regeneration after cryoinjury","volume":"94","author":"Xu","year":"2019","journal-title":"Fish Shellfish. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-017-0027-y","article-title":"Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape","volume":"2","author":"Godwin","year":"2017","journal-title":"NPJ Regen. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.celrep.2019.06.091","article-title":"Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish","volume":"28","author":"Reuter","year":"2019","journal-title":"Cell Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1073\/pnas.072560099","article-title":"Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies","volume":"99","author":"Liu","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"50163","DOI":"10.7554\/eLife.50163","article-title":"Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart","volume":"8","author":"Honkoop","year":"2019","journal-title":"Elife"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/cvr\/cvw031","article-title":"Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways","volume":"110","author":"Crippa","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.stem.2014.10.003","article-title":"In vivo activation of a conserved microRNA program induces robust mammalian heart regeneration","volume":"15","author":"Aguirre","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1600844","DOI":"10.1126\/sciadv.1600844","article-title":"Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration","volume":"2","author":"Chen","year":"2016","journal-title":"Sci. Adv."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ydbio.2013.08.012","article-title":"Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration","volume":"382","author":"Wang","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Marro, J., Pfefferli, C., Charles, A.-S.D.P., Bise, T., and Jazwinska, A. (2016). Collagen XII Contributes to Epicardial and Connective Tissues in the Zebrafish Heart during Ontogenesis and Regeneration. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0165497"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1242\/dev.078543","article-title":"The regenerative capacity of the zebrafish heart is dependent on TGF\u03b2 signaling","volume":"139","author":"Chablais","year":"2012","journal-title":"Development"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1074\/mcp.RA118.001193","article-title":"Proteomics Analysis of Extracellular Matrix Remodeling During Zebrafish Heart Regeneration","volume":"18","author":"Mosquera","year":"2019","journal-title":"Mol. Cell. Proteom."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1038\/ng.3929","article-title":"Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration","volume":"49","author":"Patterson","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.devcel.2018.01.021","article-title":"Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish","volume":"44","author":"Sharpe","year":"2018","journal-title":"Dev. Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.aar2038","article-title":"Evidence for hormonal control of heart regenerative capacity during endothermy acquisition","volume":"364","author":"Hirose","year":"2019","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1469-185X.2000.tb00054.x","article-title":"Thyroid hormones and their effects: A new perspective","volume":"75","author":"Hulbert","year":"2000","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1242\/jeb.088880","article-title":"The evolution of endothermy is explained by thyroid hormonemediated responses to cold in early vertebrates","volume":"217","author":"Little","year":"2014","journal-title":"J. Exp. Biol."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Moran, D., Softley, R., and Warrant, E.J. (2014). Eyeless Mexican Cavefish Save Energy by Eliminating the Circadian Rhythm in Metabolism. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107877"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"9668","DOI":"10.1073\/pnas.1510802112","article-title":"Melanocortin 4 receptor mutations contribute to the adaptation of cavefish to nutrient-poor conditions","volume":"112","author":"Aspirasa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","article-title":"The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response","volume":"157","author":"Puente","year":"2014","journal-title":"Cell"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/bdrc.20102","article-title":"The effect of hypoxia in development","volume":"81","author":"Webster","year":"2007","journal-title":"Birth Defects Res. Part C Embryo Today Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/1097-010X(20010401\/30)289:4<266::AID-JEZ7>3.0.CO;2-5","article-title":"Acclimation to hypoxia increases survival time of zebrafish, Danio rerio, during lethal hypoxia","volume":"289","author":"Rees","year":"2001","journal-title":"J. Exp. Zoo\u0308l."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1242\/jeb.02243","article-title":"Hypoxia induces a complex response of globin expression in zebrafish (Danio rerio)","volume":"209","author":"Roesner","year":"2006","journal-title":"J. Exp. Biol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"R63","DOI":"10.1186\/gb-2009-10-6-r63","article-title":"The conservation and evolutionary modularity of metabolism","volume":"10","author":"Sanford","year":"2009","journal-title":"Genome Biol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1101\/gr.700503","article-title":"Evolutionary Conservation of Regulatory Elements in Vertebrate Hox Gene Clusters","volume":"13","author":"Santini","year":"2003","journal-title":"Genome Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1038\/s41467-018-06617-z","article-title":"A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human","volume":"9","author":"Singh","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2015.06.017","article-title":"Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration","volume":"34","author":"Mahmoud","year":"2015","journal-title":"Dev. Cell"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.semcdb.2016.04.011","article-title":"Recent advancements in understanding endogenous heart regeneration\u2014insights from adult zebrafish and neonatal mice","volume":"58","author":"Rubin","year":"2016","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.3389\/fnins.2019.01117","article-title":"Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells","volume":"13","author":"Giffen","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_51","first-page":"1","article-title":"Macrophages directly contribute collagen to scar formation during zebrafish heart regeneration and mouse heart repair","volume":"11","author":"Cahill","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1161\/CIRCRESAHA.115.306565","article-title":"Cardiac fibrosis: The fibroblast awakens","volume":"118","author":"Travers","year":"2016","journal-title":"Circ. Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3389\/fphys.2018.00419","article-title":"The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes","volume":"9","author":"Krzyszczyk","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Harrison, M.R., Feng, X., Mo, G., Aguayo, A., Villafuerte, J., Yoshida, T., A Pearson, C., Schulte-Merker, S., and Lien, C.-L. (2019). Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. eLife, 8.","DOI":"10.7554\/eLife.42762"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e44153","DOI":"10.7554\/eLife.44153","article-title":"Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration","volume":"8","author":"Gancz","year":"2019","journal-title":"Elife"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-019-0079-2","article-title":"Vegfc\/d-dependent regulation of the lymphatic vasculature during cardiac regeneration is influenced by injury context","volume":"4","author":"Vivien","year":"2019","journal-title":"NPJ Regen. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"16029","DOI":"10.1073\/pnas.1406508111","article-title":"Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart","volume":"111","author":"LaVine","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI72181","article-title":"Macrophages are required for neonatal heart regeneration","volume":"124","author":"Aurora","year":"2014","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.cell.2017.03.050","article-title":"Macrophages Facilitate Electrical Conduction in the Heart","volume":"169","author":"Hulsmans","year":"2017","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"dev186569","DOI":"10.1242\/dev.186569","article-title":"Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration","volume":"147","author":"Koth","year":"2020","journal-title":"Development"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"eaaz3090","DOI":"10.1126\/science.aaz3090","article-title":"Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates","volume":"369","author":"Wang","year":"2020","journal-title":"Science"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"21931","DOI":"10.1073\/pnas.1016071107","article-title":"Histone H3K27ac separates active from poised enhancers and predicts developmental state","volume":"107","author":"Creyghton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1146\/annurev-biochem-051710-134100","article-title":"The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis","volume":"81","author":"Shilatifard","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/CIRCRESAHA.119.316167","article-title":"AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration","volume":"126","author":"Beisaw","year":"2020","journal-title":"Circ. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3389\/fcvm.2019.00107","article-title":"Zebrafish as a Smart Model to Understand Regeneration After Heart Injury: How Fish Could Help Humans","volume":"6","author":"Beffagna","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/dvdy.10220","article-title":"Tales of regeneration in zebrafish","volume":"226","author":"Poss","year":"2003","journal-title":"Dev. Dyn."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/wdev.160","article-title":"There and back again: Development and regeneration of the zebrafish lateral line system","volume":"4","author":"Thomas","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"ref_68","first-page":"95","article-title":"Identification of adult nephron progenitors capable of kidney regeneration in zebrafish","volume":"470","author":"Diep","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/(SICI)1096-9861(19970127)377:4<577::AID-CNE8>3.0.CO;2-#","article-title":"Axonal regrowth after spinal cord transection in adult zebrafish","volume":"377","author":"Becker","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1097-4695(20000905)44:3<289::AID-NEU1>3.0.CO;2-H","article-title":"Light-induced rod and cone cell death and regeneration in the adult albino zebrafish (Danio rerio) retina","volume":"44","author":"Vihtelic","year":"2000","journal-title":"J. Neurobiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1242\/dev.072587","article-title":"Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors","volume":"138","author":"Kroehne","year":"2011","journal-title":"Development"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15151","DOI":"10.1038\/ncomms15151","article-title":"The careg element reveals a common regulation of regeneration in the zebrafish myocardium and fin","volume":"8","author":"Pfefferli","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature17644","article-title":"Modulation of tissue repair by regeneration enhancer elements","volume":"532","author":"Kang","year":"2016","journal-title":"Nature"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"dev194019","DOI":"10.1242\/dev.194019","article-title":"Decoding an organ regeneration switch by dissecting cardiac regeneration enhancers","volume":"147","author":"Begeman","year":"2020","journal-title":"Development"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41536-018-0050-7","article-title":"Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues","volume":"3","author":"Pei","year":"2018","journal-title":"NPJ Regen. Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1242\/dev.01543","article-title":"ENU induced mutations causing congenital cardiovascular anomalies","volume":"131","author":"Yu","year":"2004","journal-title":"Development"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"4193","DOI":"10.1242\/dev.065375","article-title":"Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development","volume":"138","author":"Smith","year":"2011","journal-title":"Development"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1038\/ncomms3081","article-title":"Thymosin \u03b24-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing","volume":"4","author":"Evans","year":"2013","journal-title":"Nat. Commun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ydbio.2013.08.002","article-title":"A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration","volume":"382","author":"Mercer","year":"2013","journal-title":"Dev. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1161\/CIRCULATIONAHA.117.030801","article-title":"Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration","volume":"137","author":"Natarajan","year":"2018","journal-title":"Circulation"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ar.21492","article-title":"The Giant Danio (D. Aequipinnatus) as A Model of Cardiac Remodeling and Regeneration","volume":"295","author":"Lafontant","year":"2012","journal-title":"Anat. Rec. Adv. Integr. Anat. Evol. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cbpc.2014.02.002","article-title":"Cardiac repair and regenerative potential in the goldfish (Carassius auratus) heart","volume":"163","author":"Grivas","year":"2014","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.celrep.2018.10.072","article-title":"Heart Regeneration in the Mexican Cavefish","volume":"25","author":"Stockdale","year":"2018","journal-title":"Cell Rep."},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Van Dyck, P.K., Hockaden, N., Nelson, E.C., Koch, A.R., Hester, K.L., Pillai, N., Coffing, G.C., Burns, A.R., and Lafontant, P. (2020). Cauterization as a Simple Method for Regeneration Studies in the Zebrafish Heart. J. Cardiovasc. Dev. Dis., 7.","DOI":"10.3390\/jcdd7040041"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1242\/dev.068601","article-title":"The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion","volume":"138","author":"Wang","year":"2011","journal-title":"Development"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Chablais, F., Veit, J., Rainer, G., and Jazwinska, A. (2011). The zebrafish heart regenerates after cryoinjury-induced myocardial infarction. BMC Dev. Biol., 11.","DOI":"10.1186\/1471-213X-11-21"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2761.2004.00602.x","article-title":"An outbreak of disease resembling heart and skeletal muscle inflammation in Scottish farmed salmon, Salmo salar L., with observations on myocardial regeneration","volume":"28","author":"Ferguson","year":"2005","journal-title":"J. Fish Dis."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.devcel.2011.01.010","article-title":"Retinoic Acid Production by Endocardium and Epicardium Is an Injury Response Essential for Zebrafish Heart Regeneration","volume":"20","author":"Kikuchi","year":"2011","journal-title":"Dev. Cell"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cophys.2019.11.007","article-title":"Towards deciphering variations of heart regeneration in fish","volume":"14","author":"Jazwinska","year":"2020","journal-title":"Curr. Opin. Physiol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"4397","DOI":"10.1111\/mec.14877","article-title":"The role of gene flow in rapid and repeated evolution of cave-related traits in Mexican tetra, Astyanax mexicanus","volume":"27","author":"Herman","year":"2018","journal-title":"Mol. Ecol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12862-018-1156-7","article-title":"Evidence for late Pleistocene origin of Astyanax mexicanus cavefish","volume":"18","author":"Fumey","year":"2018","journal-title":"BMC Evol. Biol."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1002\/dvdy.24253","article-title":"The rise of Astyanax cavefish","volume":"244","author":"Gross","year":"2015","journal-title":"Dev. Dyn."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Gross, J.B. (2012). The complex origin of Astyanax cavefish. BMC Evol. Biol., 12.","DOI":"10.1186\/1471-2148-12-105"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-genet-102108-134216","article-title":"Regressive Evolution inAstyanaxCavefish","volume":"43","author":"Jeffery","year":"2009","journal-title":"Annu. Rev. Genet."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jez.b.22933","article-title":"Comparative transcriptome analysis of wild and lab populations of Astyanax mexicanus uncovers differential effects of environment and morphotype on gene expression","volume":"334","author":"Krishnan","year":"2020","journal-title":"J. Exp. Zoo\u0308l. Part B Mol. Dev. Evol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1038\/s41559-020-1234-2","article-title":"Adaptation to low parasite abundance affects immune investment and immunopathological responses of cavefish","volume":"4","author":"Box","year":"2020","journal-title":"Nat. Ecol. Evol."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"O\u2019Quin, K.E., Yoshizawa, M., Doshi, P., and Jeffery, W.R. (2013). Quantitative Genetic Analysis of Retinal Degeneration in the Blind Cavefish Astyanax mexicanus. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0057281"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/ng1700","article-title":"Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism","volume":"38","author":"Protas","year":"2005","journal-title":"Nat. Genet."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/dvdy.32","article-title":"Stable transgenesis in Astyanax mexicanus using the Tol2 transposase system","volume":"248","author":"Stahl","year":"2019","journal-title":"Dev. Dyn."},{"key":"ref_100","first-page":"e54113","article-title":"Genome Editing in Astyanax mexicanus Using Transcription Activator-like Effector Nucleases (TALENs)","volume":"2016","author":"Kowalko","year":"2016","journal-title":"J. Vis. Exp."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ydbio.2018.03.014","article-title":"CRISPR mutagenesis confirms the role of oca2 in melanin pigmentation in Astyanax mexicanus","volume":"441","author":"Klaassen","year":"2018","journal-title":"Dev. Biol."},{"key":"ref_102","first-page":"647","article-title":"Insulin resistance in cavefish as an adaptation to a nutrient-limited environment","volume":"555","author":"Riddle","year":"2018","journal-title":"Yearb. Paediatr. Endocrinol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tig.2008.11.006","article-title":"Evolutionary mutant models for human disease","volume":"25","author":"Albertson","year":"2009","journal-title":"Trends Genet."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Schnabel, K., Wu, C.-C., Kurth, T., and Weidinger, G. (2011). Regeneration of Cryoinjury Induced Necrotic Heart Lesions in Zebrafish Is Associated with Epicardial Activation and Cardiomyocyte Proliferation. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0018503"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/dev.060897","article-title":"Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish","volume":"138","author":"Peralta","year":"2011","journal-title":"Development"},{"key":"ref_106","first-page":"601","article-title":"Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes","volume":"464","author":"Kikuchi","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1002\/wdev.367","article-title":"Recent advancements in understanding fin regeneration in zebrafish","volume":"9","author":"Sehring","year":"2019","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/8\/1\/4\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:11:58Z","timestamp":1760159518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/8\/1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,16]]},"references-count":108,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["jcdd8010004"],"URL":"https:\/\/doi.org\/10.3390\/jcdd8010004","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,16]]}}}