{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:59:55Z","timestamp":1789768795753,"version":"4.0.1"},"reference-count":16,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Robert Anderson has made a huge contribution to almost all aspects of morphology and understanding of congenital cardiac malformations, none more so than the group of anomalies that many of those in the practice of paediatric cardiology and adult congenital heart disease now call \u2018Atrioventricular Septal Defect\u2019 (AVSD). In 1982, with Anton Becker working in Amsterdam, their hallmark \u2018What\u2019s in a name?\u2019 editorial was published in the Journal of Thoracic and Cardiovascular Surgery. At that time most described the group of lesions as \u2018atrioventricular canal malformation\u2019 or \u2018endocardial cushion defect\u2019. Perhaps more significantly, the so-called ostium primum defect was thought to represent a partial variant. It was also universally thought, at that time, that the left atrioventricular valve was no more than a mitral valve with a cleft in the aortic leaflet. In addition to this, lesions such as isolated cleft of the mitral valve, large ventricular septal defects opening to the inlet of the right and hearts with straddling or overriding tricuspid valve were variations of the atrioventricular canal malformation. Anderson and Becker emphasised the differences between the atrioventricular junction in the normal heart and those with a common junction for which they recommended the generic name, \u2018atrioventricular septal defect\u2019. As I will discuss, over many years, they continued to work with clinical cardiologists and cardiac surgeons to refine diagnostic criteria and transform the classification and understanding of this complex group of anomalies. Their emphasis was always on accurate diagnosis and communication, which is conveyed in this review.<\/jats:p>","DOI":"10.3390\/jcdd8020019","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T03:22:26Z","timestamp":1613359346000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atrioventricular Septal Defect: What Is in a Name?"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3301-8173","authenticated-orcid":false,"given":"Michael","family":"Rigby","sequence":"first","affiliation":[{"name":"MD FRCP FRCPCH, Royal Brompton Hospital, London SW3 6NP, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0022-5223(19)37286-1","article-title":"Atrioventricular septal defects. What\u2019s in a name?","volume":"83","author":"Becher","year":"1982","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1378\/chest.65.1.13","article-title":"The \u2018goose neck\u2019 of the endocardial cushion defect: Anatomical basis","volume":"65","author":"Blieden","year":"1974","journal-title":"Chest"},{"key":"ref_3","first-page":"296","article-title":"Anatomic observations on complete form of persistent common atrioventricular canal with special reference to atrioventricular valves","volume":"41","author":"Rastelli","year":"1966","journal-title":"Mayo Clin. Proc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0022-5223(20)31629-9","article-title":"The anatomy and embryology of endocardial cushion defects","volume":"43","author":"Alley","year":"1962","journal-title":"J. Thorac. Cardi-Ovasc. Surg."},{"key":"ref_5","first-page":"446","article-title":"Assessment of atrioventricular septal defects by two-dimensional echocar-diography","volume":"30","author":"Smallhorn","year":"1982","journal-title":"Br. Heart J."},{"key":"ref_6","first-page":"81","article-title":"Anatomy of the human atrioventricular junctions revisited","volume":"260","author":"Anderson","year":"2000","journal-title":"Anat. Rec. Adv. Integr. Anat. Evol. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0167-5273(86)90117-8","article-title":"Atrioventricular septal defects: Cross-sectional echocardiographic and mor-phologic comparisons","volume":"13","author":"Silverman","year":"1986","journal-title":"Int. J. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S0022-5223(19)38577-0","article-title":"Further observations on the morphology of atrioventricular septal defects","volume":"90","author":"Penkoske","year":"1985","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1017\/S1047951100004613","article-title":"The diagnostic features of atrioventricular septal defect with common atrioventricular junction","volume":"8","author":"Anderson","year":"1998","journal-title":"Cardiol. Young"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0003-4975(93)91163-H","article-title":"Valve morphology in complete atrioventricular septal defect: Variability relevant to operation","volume":"56","author":"Akiba","year":"1993","journal-title":"Ann. Thorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0022-5223(19)37284-8","article-title":"Left-sided obstructive lesions in atrioventricular septal defects","volume":"83","author":"Piccoli","year":"1982","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0022-5223(19)37014-X","article-title":"Anomalies of the left atrioventricular valve and related ventricular septal morphology in atrioventricular septal defects","volume":"99","author":"Ebels","year":"1990","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0022-5223(97)70111-9","article-title":"The parachute-like asymmetric mitral valve and its two papillary muscles","volume":"114","author":"Oosthoek","year":"1997","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1017\/S1047951106000758","article-title":"Echo-morphological correlates in patients with atrioventricular septal defect and common atrioventricular junction","volume":"16","author":"Mahle","year":"2006","journal-title":"Cardiol. Young"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1017\/S1047951117002244","article-title":"Nomenclature for congenital and paediatric cardiac disease: The International Paediatric and Congenital Cardiac Code (IPCCC) and the Eleventh Iteration of the International Classification of Diseases (ICD-11)","volume":"27","author":"Franklin","year":"2017","journal-title":"Cardiol. 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