{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T09:25:15Z","timestamp":1775294715139,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Cardiac rehabilitation (CR) in patients with coronary heart disease (CHD) increases adherence to a healthy lifestyle and to secondary preventive medication. A notable example of such medication is lipid-lowering therapy (LLT). LLT during CR improves quality of life and prognosis, and thus is particularly relevant for patients with diabetes mellitus, which is a major risk factor for CHD. Design: A prospective, multicenter registry study with patients from six rehabilitation centers in Germany. Methods: During CR, 1100 patients with a minimum age of 18 years and CHD documented by coronary angiography were included in a LLT registry. Results: In 369 patients (33.9%), diabetes mellitus was diagnosed. Diabetic patients were older (65.5 \u00b1 9.0 vs. 62.2 \u00b1 10.9 years, p &lt; 0.001) than nondiabetic patients and were more likely to be obese (BMI: 30.2 \u00b1 5.2 kg\/m2 vs. 27.8 \u00b1 4.2 kg\/m2, p &lt; 0.001). Analysis indicated that diabetic patients were more likely to show LDL cholesterol levels below 55 mg\/dL than patients without diabetes at the start of CR (Odds Ratio (OR) 1.9; 95% CI 1.3 to 2.9) until 3 months of follow-up (OR 1.9; 95% CI 1.2 to 2.9). During 12 months of follow-up, overall and LDL cholesterol levels decreased within the first 3 months and remained at the lower level thereafter (p &lt; 0.001), irrespective of prevalent diabetes. At the end of the follow-up period, LDL cholesterol did not differ significantly between patients with or without diabetes mellitus (p = 0.413). Conclusion: Within 3 months after CR, total and LDL cholesterol were significantly reduced, irrespective of prevalent diabetes mellitus. In addition, CHD patients with diabetes responded faster to LTT than nondiabetic patients, suggesting that diabetic patients benefit more from LLT treatment during CR.<\/jats:p>","DOI":"10.3390\/jcdd8090105","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T11:01:37Z","timestamp":1630321297000},"page":"105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Lipid-Lowering Therapy during Cardiac Rehabilitation in Patients with Diabetes Mellitus and Coronary Heart Disease"],"prefix":"10.3390","volume":"8","author":[{"given":"Thomas","family":"Wittlinger","sequence":"first","affiliation":[{"name":"Asklepios Harzkliniken GmbH, K\u00f6sliner Strasse 12, 38642 Goslar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4801-1107","authenticated-orcid":false,"given":"Bernhard","family":"Schwaab","sequence":"additional","affiliation":[{"name":"Medizinische Fakult\u00e4t, Universit\u00e4t zu L\u00fcbeck, D-23562 L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"V\u00f6ller","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Faculty of Health Sciences Brandenburg, University of Potsdam, D-14469 Potsdam, Germany"},{"name":"Klinik am See, Department of Cardiology, 15562 R\u00fcdersdorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Bongarth","sequence":"additional","affiliation":[{"name":"Clinic H\u00f6henried, 82347 Bernried, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktoria","family":"Heinze","sequence":"additional","affiliation":[{"name":"Paracelsus-Harz-Clinic, 06485 Bad Suderode, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Eckrich","sequence":"additional","affiliation":[{"name":"Clinic Tharandter Wald\u2014Hetzdorf, 09633 Halsbr\u00fccke, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manju","family":"Guha","sequence":"additional","affiliation":[{"name":"Rehabilitation Clinic Sendesaal, 28329 Bremen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Richter","sequence":"additional","affiliation":[{"name":"Coordination Center for Clinical Studies, Martin Luther-University Halle Wittenberg, 06120 Halle, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Schlitt","sequence":"additional","affiliation":[{"name":"Paracelsus-Harz-Clinic, 06485 Bad Suderode, Germany"},{"name":"Medical Faculty, Martin Luther-University, 06120 Halle Wittenberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","article-title":"2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD","volume":"41","author":"Cosentino","year":"2020","journal-title":"Eur. 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