{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:05:50Z","timestamp":1788807950530,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,10,3]],"date-time":"2021-10-03T00:00:00Z","timestamp":1633219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Major adverse cardiac events, defined as death or myocardial infarction, are common causes of perioperative mortality and major morbidity in patients undergoing non-cardiac surgery. Reduction of perioperative cardiovascular risk in relation to non-cardiac surgery requires a stepwise patient evaluation that integrates clinical risk factors, functional status and the estimated stress of the planned surgical procedure. Major guidelines on preoperative cardiovascular risk assessment recommend to establish, firstly, the risk of surgery per se (low, moderate, high) and the related timing (elective vs. urgent\/emergent), evaluate the presence of unstable cardiac conditions or a recent coronary revascularization (percutaneous coronary intervention or coronary artery bypass grafting), assess the functional capacity of the patient (usually expressed in metabolic equivalents), determine the value of non-invasive and\/or invasive cardiovascular testing and then combine these data in estimating perioperative risk for major cardiac adverse events using validated scores (Revised Cardiac Risk Index (RCRI) or National Surgical Quality Improvement Program (NSQIP)). This stepwise approach has the potential to guide clinicians in determining which patients could benefit from cardiovascular therapy and\/or coronary artery revascularization before non-cardiac surgery towards decreasing the incidence of perioperative morbidity and mortality. Finally, it should be highlighted that there is a need to implement specific strategies in the 2019 Coronavirus disease (COVID-19) pandemic to minimize the risk of transmission of COVID-19 infection during the preoperative risk assessment process.<\/jats:p>","DOI":"10.3390\/jcdd8100126","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T16:23:58Z","timestamp":1633623838000},"page":"126","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Preoperative Assessment and Management of Cardiovascular Risk in Patients Undergoing Non-Cardiac Surgery: Implementing a Systematic Stepwise Approach during the COVID-19 Pandemic Era"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2769-9950","authenticated-orcid":false,"given":"Eduardo","family":"Bossone","sequence":"first","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Cademartiri","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Center, IRCCS SDN, 80143 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hani","family":"AlSergani","sequence":"additional","affiliation":[{"name":"Cardiac Centre, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Chianese","sequence":"additional","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mehta","sequence":"additional","affiliation":[{"name":"ProMedica Monroe Regional Hospital, Monroe, MI 48162, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-9948","authenticated-orcid":false,"given":"Valentina","family":"Capone","sequence":"additional","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Ruotolo","sequence":"additional","affiliation":[{"name":"Vascular Surgery Unit, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran Hayat","family":"Tarrar","sequence":"additional","affiliation":[{"name":"Henry Ford Allegiance Hospital, 205 North East Avenue, Jackson, MI 49201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Frangiosa","sequence":"additional","affiliation":[{"name":"Post Operative Intensive Care Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Vriz","sequence":"additional","affiliation":[{"name":"Cardiac Centre, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Maffei","sequence":"additional","affiliation":[{"name":"Post Operative Intensive Care Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-3205","authenticated-orcid":false,"given":"Roberto","family":"Annunziata","sequence":"additional","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9682-3815","authenticated-orcid":false,"given":"Domenico","family":"Galzerano","sequence":"additional","affiliation":[{"name":"Cardiac Centre, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4880-5679","authenticated-orcid":false,"given":"Brigida","family":"Ranieri","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Center, IRCCS SDN, 80143 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sepe","sequence":"additional","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-2103","authenticated-orcid":false,"given":"Andrea","family":"Salzano","sequence":"additional","affiliation":[{"name":"Cardiovascular Imaging Center, IRCCS SDN, 80143 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosangela","family":"Cocchia","sequence":"additional","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Majolo","sequence":"additional","affiliation":[{"name":"Health Management Office, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Russo","sequence":"additional","affiliation":[{"name":"Health Management Office, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Longo","sequence":"additional","affiliation":[{"name":"Healthcare Direction, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Muto","sequence":"additional","affiliation":[{"name":"Diagnostic and Interventional Neuroradiology, AORN Antonio Cardarelli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Fedelini","sequence":"additional","affiliation":[{"name":"Urology Department, Antonio Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Esposito","sequence":"additional","affiliation":[{"name":"Liver Intensive Care Unit, AORN A. Cardarelli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-8500","authenticated-orcid":false,"given":"Alessandro","family":"Perrella","sequence":"additional","affiliation":[{"name":"Infectious Disease of Healthcare Direction, AORN Antonio Cardarelli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Guggino","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, Antonio Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Raiola","sequence":"additional","affiliation":[{"name":"Health Management Office, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Catalano","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department \u201cCardarelli\u201d Hospital Naples, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"De Palma","sequence":"additional","affiliation":[{"name":"UOC Chirurgia Generale 2, AORN Cardarelli, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigia","family":"Romano","sequence":"additional","affiliation":[{"name":"Department of General and Emergency Radiology, \u201cAntonio Cardarelli\u201d Hospital, Antonio Cardarelli St. 9, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Romano","sequence":"additional","affiliation":[{"name":"Orthopedic Unit, Antonio Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Coppola","sequence":"additional","affiliation":[{"name":"Health Management Office, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciro","family":"Mauro","sequence":"additional","affiliation":[{"name":"Cardiology Division, A. Cardarelli Hospital, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Durham, North Carolina, 300 W Morgan St, Durham, NC 27701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1093\/eurheartj\/ehu285","article-title":"2014 ESC\/ESA Guidelines on non-cardiac surgery: Cardiovascular assessment and management","volume":"35","author":"Kristensen","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1001\/jama.2020.7840","article-title":"Perioperative Cardiovascular Risk Assessment and Management for Noncardiac Surgery","volume":"324","author":"Smilowitz","year":"2020","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cjca.2016.09.008","article-title":"Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery","volume":"33","author":"Duceppe","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_4","first-page":"e278","article-title":"2014 ACC\/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery","volume":"130","author":"Fleisher","year":"2014","journal-title":"Circulation"},{"key":"ref_5","unstructured":"Zipes, D.P., Libby, P., Bonow, R.O., Mann, D.L., and Tomaselli, G.F. (2018). Braunwald\u2019s Heart Disease: A Textbook of Cardiovascular Medicine, Elsevier. [11th ed.]."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/ehjci\/jeaa072","article-title":"COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel","volume":"21","author":"Skulstad","year":"2020","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_7","unstructured":"The European Society for Cardiology (2020, June 10). ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic. Available online: https:\/\/www.escardio.org\/Education\/COVID-19-and-Cardiology\/ESC-COVID-19-Guidance."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Bossone, E., Mauro, C., Maiellaro, A., Raiola, E., Cocchia, R., Ranieri, B., Sepe, C., Capone, V., Chianese, S., and Maramaldi, R. (2021). Cardiac teleconsulting in the time of COVID-19 global pandemic: The \u201cAntonio Cardarelli\u201d Hospital project. Monaldi Arch. Chest Dis., 91.","DOI":"10.4081\/monaldi.2021.1779"},{"key":"ref_9","unstructured":"Societ\u00e0 Italiana di Ecocardiografia e Cardiovascular Imaging (SIECVI) (2020, June 10). Documento ad uso Degli Operatori di Ecografia Cardiovascolare per COVID-19. Available online: https:\/\/www.siec.it\/download\/siecvi-documento-ad-uso-degli-operatori-di-ecografia-cardiovascolare-per-covid-19."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1016\/j.jacc.2016.07.760","article-title":"Efficacy and Safety of Dual Antiplatelet Therapy After Complex PCI","volume":"68","author":"Giustino","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation","volume":"39","author":"Ibanez","year":"2017","journal-title":"Eur. Heart J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"Collet","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_13","first-page":"417","article-title":"A Multidisciplinary Approach on the Perioperative Antithrombotic Management of Patients with Coronary Stents Undergoing Surgery","volume":"11","author":"Rossini","year":"2018","journal-title":"JACC: Cardiovasc. Interv."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.CIR.100.10.1043","article-title":"Derivation and Prospective Validation of a Simple Index for Prediction of Cardiac Risk of Major Noncardiac Surgery","volume":"100","author":"Lee","year":"1999","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1161\/CIRCULATIONAHA.110.015701","article-title":"Development and Validation of a Risk Calculator for Prediction of Cardiac Risk After Surgery","volume":"124","author":"Gupta","year":"2011","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1161\/hc3901.095960","article-title":"Exercise Standards for Testing and Training","volume":"104","author":"Fletcher","year":"2001","journal-title":"Circulation"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1056\/NEJMoa011858","article-title":"Exercise Capacity and Mortality among Men Referred for Exercise Testing","volume":"346","author":"Myers","year":"2002","journal-title":"New Engl. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0002-9149(89)90496-7","article-title":"A brief self-administered questionnaire to determine functional capacity (The Duke Activity Status Index)","volume":"64","author":"Hlatky","year":"1989","journal-title":"Am. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/eurheartj\/ehq456","article-title":"Troponin elevation in coronary vs. non-coronary disease","volume":"32","author":"Agewall","year":"2010","journal-title":"Eur. Heart J."},{"key":"ref_21","unstructured":"Feigenbaum, H., Armstrong, W.F., and Ryan, T. (2019). Feigenbaum\u2019s Echocardiography, Lippincott Williams & Wilkins."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/ehjci\/jey145","article-title":"The use of handheld ultrasound devices: A position statement of the European Association of Cardiovascular Imaging (2018 update)","volume":"20","author":"Cardim","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_24","unstructured":"Zipes, D.P., and Libby, P. (2019). Braunwald\u2019s Heart Disease: A Textbook of Cardiovascular Medicine, 2-Volume Set, Elsevier. [11th ed.]."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.jacc.2021.06.019","article-title":"Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease","volume":"78","author":"Serruys","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","unstructured":"Lombardi, M., and Plein, S. (2018). The EACVI Textbook of Cardiovascular Magnetic Resonance, Oxford University Press."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1016\/j.jacc.2009.11.011","article-title":"ACCF\/ACR\/AHA\/NASCI\/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents","volume":"55","author":"Hundley","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e123","DOI":"10.1161\/CIR.0000000000000404","article-title":"2016 ACC\/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients with Coronary Artery Disease","volume":"134","author":"Levine","year":"2016","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Steffel, J., Collins, R., Antz, M., Cornu, P., Desteghe, L., Haeusler, K.G., Oldgren, J., Reinecke, H., Roldan-Schilling, V., and Rowell, N. (2021). 2021 European Heart Rhythm Association Practical Guide on the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation. EP Eur.","DOI":"10.1093\/europace\/euab157"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1001\/jama.2013.4135","article-title":"Association of Perioperative \u03b2-Blockade with Mortality and Cardiovascular Morbidity Following Major Noncardiac Surgery","volume":"309","author":"London","year":"2013","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.jacc.2010.05.056","article-title":"Timing of Pre-Operative Beta-Blocker Treatment in Vascular Surgery Patients: Influence on Post-Operative Outcome","volume":"56","author":"Flu","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1016\/j.jacc.2014.07.939","article-title":"Perioperative Beta Blockade in Noncardiac Surgery: A Systematic Review for the 2014 ACC\/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery","volume":"64","author":"Wijeysundera","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/ATVBAHA.115.306885","article-title":"Synergistic Inhibition of Both P2Y 1 and P2Y 12 Adenosine Diphosphate Receptors as Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis","volume":"36","author":"Gremmel","year":"2016","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nrcardio.2015.87","article-title":"Defining the optimal duration of DAPT after PCI with DES","volume":"12","author":"Eisen","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4244\/EIJV10I1A8","article-title":"Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: A consensus document from Italian cardiological, surgical and anaesthesiological societies","volume":"10","author":"Rossini","year":"2014","journal-title":"EuroIntervention"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s11239-012-0737-3","article-title":"Pharmacodynamic effects of cangrelor and clopidogrel: The platelet function substudy from the cangrelor versus standard therapy to achieve optimal management of platelet inhibition (CHAMPION) trials","volume":"34","author":"Angiolillo","year":"2012","journal-title":"J. Thromb. Thrombolysis"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2147\/TCRM.S84210","article-title":"New oral anticoagulants: Their advantages and disadvantages compared with vitamin K antagonists in the prevention and treatment of patients with thromboembolic events","volume":"ume 11","author":"Mekaj","year":"2015","journal-title":"Ther. Clin. Risk Manag."}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/8\/10\/126\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:09:11Z","timestamp":1760166551000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/8\/10\/126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,3]]},"references-count":38,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jcdd8100126"],"URL":"https:\/\/doi.org\/10.3390\/jcdd8100126","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,3]]}}}