{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:52:11Z","timestamp":1760151131595,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:00:00Z","timestamp":1644969600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Choroid plexus cysts (CPCs) are often transient and benign findings observed in pregnancy screenings. This study aimed to examine the association between the frequency of congenital heart diseases and the detection of CPCs. In this prospective case-control study, pregnant mothers with no predisposing risk factors for the development of fetal cardiac abnormalities were eligible for entry. Based on the presence or absence of CPCs on ultrasound, the enrolled fetuses were divided into two groups. All patients (n = 100) underwent two-dimensional and color Doppler echocardiography to identify potential cardiac anomalies. Overall, CPCs were detected in 53 enrolled fetuses, and the remainder were enrolled as controls (n = 47). Pathological findings, such as echogenic intracardiac focus (EIF), ductal spasm, atrial septal defect (ASD), pericardial effusion, cardiomyopathy, and congenital heart disease were found in neither group. In the CPC group, two mild and six trivial cases of tricuspid regurgitation (TR) were detected. In the controls, five cases of trivial TR were identified. In conclusion, the presence of CPCs was not associated with significant functional or structural fetal cardiac abnormalities, which may be due to altered developmental mechanisms.<\/jats:p>","DOI":"10.3390\/jcdd9020060","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T21:36:24Z","timestamp":1645047384000},"page":"60","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the Association between Fetal Cardiac Disorders with Choroid Plexus Cyst in Fetuses"],"prefix":"10.3390","volume":"9","author":[{"given":"Mohammad Sedigh","family":"Dakkali","sequence":"first","affiliation":[{"name":"School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743463, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arman","family":"Karimi Behnagh","sequence":"additional","affiliation":[{"name":"Echocardiography Research Center, Rajaei Cardiovascular, Medical and Research Center, Iran University of Medical Sciences, Tehran 1995614331, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9930-114X","authenticated-orcid":false,"given":"Shakiba","family":"Ghasemi Assl","sequence":"additional","affiliation":[{"name":"School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atiyeh","family":"Kimiaeifar","sequence":"additional","affiliation":[{"name":"School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Radgoodarzi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/1097-0223(200008)20:8<657::AID-PD866>3.0.CO;2-S","article-title":"Fetal choroid plexus cysts: Are we there yet?","volume":"20","author":"Walkinshaw","year":"2000","journal-title":"Prenat. 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