{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:21:27Z","timestamp":1780546887941,"version":"3.54.1"},"reference-count":42,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011949","name":"Abbott vascular","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Computed tomography derived Fractional Flow Reserve (CT-FFR) has been shown to decrease the referral rate for invasive coronary angiography (ICA). The purpose of the study was to evaluate the diagnostic performance of CT-FFR compared to hyperemia-free index Resting Full-cycle Ratio (RFR) in patients with relevant aortic stenosis (AS) and intermediate coronary stenosis. Methods: 41 patients with 46 coronary lesions underwent ICA with quantitative coronary angiography (QCA), pressure wire assessment and routine pre-transcatheter aortic valve replacement (TAVR) computed tomography (CT). CT-FFR analysis was performed using prototype on-site software. Results: RFR showed a significant correlation with CT-FFR (Pearson\u2019s correlation, r = 0.632, p &lt; 0.001). On a per-lesion basis, diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of CT-FFR were 82.6% (95% CI 68.6\u201392.2), 69.6% (95% CI 47.1\u201386.8), 95.7% (95% CI\u2009 78.1\u201399.9), 94.1% (95% CI 69.8\u201399.1), and 75.9% (95% CI 62.7\u201385.4), respectively. The optimal cutoff value of the CT-FFR for RFR \u2264 0.89 prediction was 0.815. The area under the receiver curve showed a larger area under the curve for CT-FFR (0.87; 95% CI 0.75\u20130.98) compared with CTA stenosis of \u226550% (0.54, 95% CI 0.38\u20130.71), CTA \u2265 70% (0.72, 95% CI 0.57\u20130.87) and QCA \u2265 50% (0.67, 95% CI 0.52\u20130.83). Conclusions: CT-FFR assessed by routine pre-TAVR CT is safe and feasible and shows a significant correlation with RFR in patients with AS. CT-FFR is superior to QCA \u2265 50%, CT \u2265 50% and CT \u2265 70% in assessing the hemodynamic relevance of intermediate coronary lesions. Thus, CT-FFR has the potential to guide revascularization in patients with AS.<\/jats:p>","DOI":"10.3390\/jcdd9040116","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T21:44:06Z","timestamp":1649972646000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility and Comparison of Resting Full-Cycle Ratio and Computed Tomography Fractional Flow Reserve in Patients with Severe Aortic Valve Stenosis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5810-2868","authenticated-orcid":false,"given":"Hendrik","family":"Wienemann","sequence":"first","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel C.","family":"Langenbach","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Mauri","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9112-2753","authenticated-orcid":false,"given":"Maryam","family":"Banazadeh","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Lee","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Breidert","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-8892","authenticated-orcid":false,"given":"Alexander","family":"Hof","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaveh","family":"Eghbalzadeh","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Halbach","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Maintz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Baldus","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Bunck","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6990-8135","authenticated-orcid":false,"given":"Matti","family":"Adam","sequence":"additional","affiliation":[{"name":"Clinic III for Internal Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, Kerpener Str. 61, 50937 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e006092","DOI":"10.1161\/JAHA.117.006092","article-title":"Impact of Coronary Artery Disease on 30-Day and 1-Year Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement: A Meta-Analysis","volume":"6","author":"Sankaramangalam","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ahj.2014.04.022","article-title":"Diagnostic accuracy of multidetector computed tomography coronary angiography in 325 consecutive patients referred for transcatheter aortic valve replacement","volume":"168","author":"Andreini","year":"2014","journal-title":"Am. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s12265-021-10099-8","article-title":"Computed Tomography Angiography for the Diagnosis of Coronary Artery Disease Among Patients Undergoing Transcatheter Aortic Valve Implantation","volume":"14","author":"Meier","year":"2021","journal-title":"J. Cardiovasc. Trans. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11239-017-1521-1","article-title":"Routine CT angiography to detect severe coronary artery disease prior to transcatheter aortic valve replacement","volume":"44","author":"Chava","year":"2017","journal-title":"J. Thromb Thrombolysis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa0807611","article-title":"Fractional flow reserve versus angiography for guiding percutaneous coronary intervention","volume":"360","author":"Tonino","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/S0140-6736(15)00057-4","article-title":"Fractional flow reserve versus angiography for guidance of PCI in patients with multivessel coronary artery disease (FAME): 5-year follow-up of a randomised controlled trial","volume":"386","author":"Zimmermann","year":"2015","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1056\/NEJMoa1616540","article-title":"Instantaneous Wave-free Ratio versus Fractional Flow Reserve to Guide PCI","volume":"376","author":"Christiansen","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1056\/NEJM199606273342604","article-title":"Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses","volume":"334","author":"Pijls","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4244\/EIJ-D-18-00342","article-title":"Validation of a novel non-hyperaemic index of coronary artery stenosis severity: The Resting Full-cycle Ratio (VALIDATE RFR) study","volume":"14","author":"Svanerud","year":"2018","journal-title":"EuroIntervention"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Marin, F., Scarsini, R., Kotronias, R.A., Printzios, D.T., Burrage, M.K., Bray, J.J.H., Ciofani, J.L., Venturi, G., Pighi, M., and Maria GL de Banning, A.P. (2021). Aortic Valve Disease and Associated Complex CAD: The Interventional Approach. J. Clin. Med., 10.","DOI":"10.3390\/jcm10050946"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.jacc.2011.06.066","article-title":"Diagnosis of ischemia-causing coronary stenoses by noninvasive fractional flow reserve computed from coronary computed tomographic angiograms. Results from the prospective multicenter DISCOVER-FLOW (Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve) study","volume":"58","author":"Koo","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.jacc.2013.11.043","article-title":"Diagnostic performance of noninvasive fractional flow reserve derived from coronary computed tomography angiography in suspected coronary artery disease: The NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps)","volume":"63","author":"Leipsic","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s12928-019-00609-6","article-title":"Discordance of intracoronary pressure-based indices in severe angiographic stenosis: Are we missing the flow?","volume":"35","author":"Michail","year":"2020","journal-title":"Cardiovasc. Interv. Ther."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1148\/radiol.2018171291","article-title":"Coronary CT Angiography-derived Fractional Flow Reserve: Machine Learning Algorithm versus Computational Fluid Dynamics Modeling","volume":"288","author":"Tesche","year":"2018","journal-title":"Radiology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jcct.2012.11.002","article-title":"SCCT expert consensus document on computed tomography imaging before transcatheter aortic valve implantation (TAVI)\/transcatheter aortic valve replacement (TAVR)","volume":"6","author":"Achenbach","year":"2012","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on myocardial revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1056\/NEJMoa1700445","article-title":"Use of the Instantaneous Wave-free Ratio or Fractional Flow Reserve in PCI","volume":"376","author":"Davies","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1056\/NEJMoa1408758","article-title":"Fractional flow reserve-guided PCI for stable coronary artery disease","volume":"371","author":"Bruyne","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1016\/j.jcin.2018.07.027","article-title":"Instantaneous Wave-Free Ratio for the Assessment of Intermediate Coronary Artery Stenosis in Patients With Severe Aortic Valve Stenosis: Comparison With Myocardial Perfusion Scintigraphy","volume":"11","author":"Yamanaka","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.jcin.2018.07.019","article-title":"Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement: Implications for Clinical Indices of Coronary Stenosis Severity","volume":"11","author":"Ahmad","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e002443","DOI":"10.1161\/CIRCINTERVENTIONS.114.002443","article-title":"Impact of Aortic Valve Stenosis on Coronary Hemodynamics and the Instantaneous Effect of Transcatheter Aortic Valve Implantation","volume":"8","author":"Wiegerinck","year":"2015","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1253\/circj.CJ-19-1110","article-title":"All Resting Physiological Indices May Not Be Equivalent\u2014Comparison Between the Diastolic Pressure Ratio and Resting Full-Cycle Ratio","volume":"84","author":"Hoshino","year":"2020","journal-title":"Circ. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1161\/hc0402.102931","article-title":"Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries","volume":"105","author":"Rajappan","year":"2002","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jacc.2016.05.071","article-title":"Coronary Physiology During Exercise and Vasodilation in the Healthy Heart and in Severe Aortic Stenosis","volume":"68","author":"Lumley","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e011331","DOI":"10.1161\/CIRCINTERVENTIONS.121.011331","article-title":"Long-Term Changes in Invasive Physiological Pressure Indices of Stenosis Severity Following Transcatheter Aortic Valve Implantation","volume":"15","author":"Sabbah","year":"2021","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Li, M., Du, X.-M., Jin, Z.-T., Peng, Z.-H., Ding, J., and Li, L. (2014). The diagnostic performance of coronary artery angiography with 64-MSCT and post 64-MSCT: Systematic review and meta-analysis. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0084937"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ijcard.2009.02.031","article-title":"Defining the appropriate CTA stenosis threshold for gatekeeping to invasive angiography: 50% or 70%?","volume":"144","author":"Nicol","year":"2010","journal-title":"Int. J. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jcmg.2015.08.021","article-title":"CT Angiography for the Prediction of Hemodynamic Significance in Intermediate and Severe Lesions: Head-to-Head Comparison With Quantitative Coronary Angiography Using Fractional Flow Reserve as the Reference Standard","volume":"9","author":"Budoff","year":"2016","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jcin.2014.03.004","article-title":"Fractional flow reserve calculation from 3-dimensional quantitative coronary angiography and TIMI frame count: A fast computer model to quantify the functional significance of moderately obstructed coronary arteries","volume":"7","author":"Tu","year":"2014","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1016\/j.jacc.2017.10.035","article-title":"Diagnostic Accuracy of Angiography-Based Quantitative Flow Ratio Measurements for Online Assessment of Coronary Stenosis","volume":"70","author":"Xu","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e009603","DOI":"10.1161\/JAHA.118.009603","article-title":"Diagnostic Performance of In-Procedure Angiography-Derived Quantitative Flow Reserve Compared to Pressure-Derived Fractional Flow Reserve: The FAVOR II Europe-Japan Study","volume":"7","author":"Westra","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/S0140-6736(21)02248-0","article-title":"Angiographic quantitative flow ratio-guided coronary intervention (FAVOR III China): A multicentre, randomised, sham-controlled trial","volume":"398","author":"Xu","year":"2021","journal-title":"Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.4244\/EIJ-D-19-01001","article-title":"Angiography-based quantitative flow ratio versus fractional flow reserve in patients with coronary artery disease and severe aortic stenosis","volume":"16","author":"Paradis","year":"2020","journal-title":"EuroIntervention"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00392-014-0806-z","article-title":"Diagnostic accuracy of computed tomography angiography for the detection of coronary artery disease in patients referred for transcatheter aortic valve implantation","volume":"104","author":"Opolski","year":"2015","journal-title":"Clin. Res. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jcmg.2021.09.013","article-title":"Combined Coronary CT-Angiography and TAVR Planning for Ruling Out Significant Coronary Artery Disease: Added Value of Machine-Learning-Based CT-FFR","volume":"15","author":"Gohmann","year":"2021","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Brandt, V., Schoepf, U.J., Aquino, G.J., Bekeredjian, R., Varga-Szemes, A., Emrich, T., Bayer, R.R., Schwarz, F., Kroencke, T.J., and Tesche, C. (2022). Impact of machine-learning-based coronary computed tomography angiography\u2013derived fractional flow reserve on decision-making in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement. Eur. Radiol.","DOI":"10.1007\/s00330-022-08758-8"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jcin.2011.03.013","article-title":"Optimal intravascular ultrasound criteria and their accuracy for defining the functional significance of intermediate coronary stenoses of different locations","volume":"4","author":"Koo","year":"2011","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jcmg.2019.03.003","article-title":"1-Year Impact on Medical Practice and Clinical Outcomes of FFRCT: The ADVANCE Registry","volume":"13","author":"Patel","year":"2020","journal-title":"JACC Cardiovasc. Imaging."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Baumann, S., Hirt, M., Rott, C., \u00d6zdemir, G.H., Tesche, C., Becher, T., Weiss, C., Hetjens, S., Akin, I., and Schoenberg, S.O. (2020). Comparison of Machine Learning Computed Tomography-Based Fractional Flow Reserve and Coronary CT Angiography-Derived Plaque Characteristics with Invasive Resting Full-Cycle Ratio. J. Clin. Med., 9.","DOI":"10.3390\/jcm9030714"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00392-019-01562-3","article-title":"Correlation of machine learning computed tomography-based fractional flow reserve with instantaneous wave free ratio to detect hemodynamically significant coronary stenosis","volume":"109","author":"Baumann","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1093\/ehjci\/jey104","article-title":"Diagnostic performance of on-site computed CT-fractional flow reserve based on fluid structure interactions: Comparison with invasive fractional flow reserve and instantaneous wave-free ratio","volume":"20","author":"Fujimoto","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/9\/4\/116\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:53:46Z","timestamp":1760136826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/9\/4\/116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,14]]},"references-count":42,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["jcdd9040116"],"URL":"https:\/\/doi.org\/10.3390\/jcdd9040116","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,14]]}}}