{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:04:14Z","timestamp":1762049054729,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Research, Innovation and Digitization","award":["28 PFE\/30 December 2021"],"award-info":[{"award-number":["28 PFE\/30 December 2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Polysplenia syndrome represents a type of left atrial isomerism characterized by multiple small spleens, often associated with cardiac malformations and with situs ambiguus of the abdominal organs. The case presented is of a one-month-old male infant, weighing approximately 3000 g, born at the County Clinical Emergency Hospital of Sibiu, who was hospitalized from birth until death. The patient suffered cardio-respiratory arrest due to severe hypoxia and septicemia on the background of a series of complex cardiac malformations associated with congenital abdominal organ anomalies. Examination of the body revealed a common atrium with complete atrioventricular canal defect, left ventricular hypertrophy, right ventricle hypoplasia, truncus arteriosus, superior vena cava duplication, bilobation of the lungs, situs ambiguous of the abdominal organs with right-sided stomach, a midline liver, gall bladder agenesis, multiple right-sided spleens and complete inversion of the intestines and pancreas. Histopathology concluded that the patient suffered cardiac lesions consistent with infantile lactic acidosis, as well as pulmonary modifications suggesting congenital alveolar dysplasia and altered hepatic architecture compatible with fibrosis.<\/jats:p>","DOI":"10.3390\/jcdd9050135","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"135","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Rare Case of Polysplenia Syndrome Associated with Severe Cardiac Malformations and Congenital Alveolar Dysplasia in a One-Month-Old Infant: A Complete Macroscopic and Histopathologic Study"],"prefix":"10.3390","volume":"9","author":[{"given":"Cosmin Ioan","family":"Mohor","sequence":"first","affiliation":[{"name":"Department of Basic Science, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-9828","authenticated-orcid":false,"given":"Sorin Radu","family":"Fleaca","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Oprinca Muja","sequence":"additional","affiliation":[{"name":"Department of Basic Science, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Calin","family":"Oprinca","sequence":"additional","affiliation":[{"name":"Department of Basic Science, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-8515","authenticated-orcid":false,"given":"Mihai Dan","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1894-4475","authenticated-orcid":false,"given":"Radu","family":"Chicea","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian Gheorghe","family":"Boicean","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horatiu","family":"Dura","sequence":"additional","affiliation":[{"name":"Department of Basic Science, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciprian","family":"Tanasescu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas Catalin Ionut","family":"Ion","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Faur","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-7591","authenticated-orcid":false,"given":"Ciprian Ionut","family":"Bacila","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florina","family":"Batar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calin Ilie","family":"Mohor","sequence":"additional","affiliation":[{"name":"Department of Basic Science, Faculty of Medicine, Lucian Blaga University of Sibiu, 550024 Sibiu, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2183\/pjab.96.021","article-title":"Molecular and cellular basis of left-right asymmetry in vertebrates","volume":"96","author":"Hamada","year":"2020","journal-title":"Proc. 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