{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:57:59Z","timestamp":1792043879987,"version":"4.4.0"},"reference-count":166,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cRicerca Corrente\u201d funding"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>The endothelium is composed of a monolayer of endothelial cells, lining the interior surface of blood and lymphatic vessels. Endothelial cells display important homeostatic functions, since they are able to respond to humoral and hemodynamic stimuli. Thus, endothelial dysfunction has been proposed as a key and early pathogenic mechanism in many clinical conditions. Given the relevant repercussions on cardiovascular risk, the complex interplay between endothelial dysfunction and systemic arterial hypertension has been a matter of study in recent years. Numerous articles have been published on this issue, all of which contribute to providing an interesting insight into the molecular mechanisms of endothelial dysfunction in arterial hypertension and its role as a biomarker of inflammation, oxidative stress, and vascular disease. The prognostic and therapeutic implications of endothelial dysfunction have also been analyzed in this clinical setting, with interesting new findings and potential applications in clinical practice and future research. The aim of this review is to summarize the pathophysiology of the relationship between endothelial dysfunction and systemic arterial hypertension, with a focus on the personalized pharmacological and rehabilitation strategies targeting endothelial dysfunction while treating hypertension and cardiovascular comorbidities.<\/jats:p>","DOI":"10.3390\/jcdd9050136","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Mechanisms and Clinical Implications of Endothelial Dysfunction in Arterial Hypertension"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9398-0428","authenticated-orcid":false,"given":"Pasquale","family":"Ambrosino","sequence":"first","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1612-5329","authenticated-orcid":false,"given":"Tiziana","family":"Bachetti","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Scientific Direction, 27100 Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvestro Ennio","family":"D\u2019Anna","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brurya","family":"Galloway","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-5901","authenticated-orcid":false,"given":"Andrea","family":"Bianco","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"D\u2019Agnano","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antimo","family":"Papa","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Cardiac Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8643-658X","authenticated-orcid":false,"given":"Andrea","family":"Motta","sequence":"additional","affiliation":[{"name":"Institute of Biomolecular Chemistry, National Research Council, 80078 Pozzuoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-7037","authenticated-orcid":false,"given":"Fabio","family":"Perrotta","sequence":"additional","affiliation":[{"name":"Department of Translational Medical Sciences, University of Campania \u201cLuigi Vanvitelli\u201d, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6751-9921","authenticated-orcid":false,"given":"Mauro","family":"Maniscalco","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri IRCCS, Pulmonary Rehabilitation Unit of Telese Terme Institute, 82037 Telese Terme, Italy"},{"name":"Department of Clinical Medicine and Surgery, \u201cFederico II\u201d University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18014","DOI":"10.1038\/nrdp.2018.14","article-title":"Hypertension","volume":"4","author":"Oparil","year":"2018","journal-title":"Nat. Rev. Dis Prim."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/HJH.0000000000002453","article-title":"2020 International Society of Hypertension global hypertension practice guidelines","volume":"38","author":"Unger","year":"2020","journal-title":"J. Hypertens"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990\u20132019: Update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/5584_2016_90","article-title":"Endothelial dysfunction and hypertension","volume":"956","author":"Konukoglu","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ambrosino, P., Grassi, G., and Maniscalco, M. (2021). Endothelial dysfunction: From a pathophysiological mechanism to a potential therapeutic target. Biomedicines, 10.","DOI":"10.3390\/biomedicines10010078"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1161\/hy1201.096575","article-title":"Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery","volume":"38","author":"Gokce","year":"2001","journal-title":"Hypertension"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"99S","DOI":"10.1016\/j.amjmed.2003.09.016","article-title":"Endothelial function, inflammation, and prognosis in cardiovascular disease","volume":"115","author":"Gonzalez","year":"2003","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1161\/01.RES.53.5.557","article-title":"Role of endothelium in responses of vascular smooth muscle","volume":"53","author":"Furchgott","year":"1983","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0733-8651(03)00073-0","article-title":"Endothelial control of vasomotion and nitric oxide production","volume":"21","author":"Harrison","year":"2003","journal-title":"Cardiol. Clin."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1073\/pnas.74.8.3203","article-title":"Nitric oxide activates guanylate cyclase and increases guanosine 3\u2019:5\u2019-cyclic monophosphate levels in various tissue preparations","volume":"74","author":"Arnold","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1161\/CIRCULATIONAHA.105.602532","article-title":"Endothelial nitric oxide synthase in vascular disease: From marvel to menace","volume":"113","author":"Forstermann","year":"2006","journal-title":"Circulation"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"da Silva, G.M., da Silva, M.C., Nascimento, D.V.G., Lima Silva, E.M., Gouvea, F.F.F., de Franca Lopes, L.G., Araujo, A.V., Ferraz Pereira, K.N., and de Queiroz, T.M. (2021). Nitric oxide as a central molecule in hypertension: Focus on the vasorelaxant activity of new nitric oxide donors. Biology, 10.","DOI":"10.3390\/biology10101041"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"798958","DOI":"10.3389\/fmed.2021.798958","article-title":"Endothelial dysfunction in hypertension: Current concepts and clinical implications","volume":"8","author":"Gallo","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/HYPERTENSIONAHA.114.03575","article-title":"Endothelial dysfunction and hypertension","volume":"64","author":"Brandes","year":"2014","journal-title":"Hypertension"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.0000112565.60887.1E","article-title":"Clinical correlates and heritability of flow-mediated dilation in the community: The Framingham heart study","volume":"109","author":"Benjamin","year":"2004","journal-title":"Circulation"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s11739-017-1690-0","article-title":"Clinical assessment of endothelial function in patients with chronic obstructive pulmonary disease: A systematic review with meta-analysis","volume":"12","author":"Ambrosino","year":"2017","journal-title":"Intern. Emerg. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.2174\/13816128113196660748","article-title":"eNOS uncoupling in cardiovascular diseases\u2014The role of oxidative stress and inflammation","volume":"20","author":"Karbach","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.medici.2016.01.005","article-title":"Hypertension and physical exercise: The role of oxidative stress","volume":"52","author":"Matchkov","year":"2016","journal-title":"Medicina (Kaunas)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/MNH.0b013e32832923c3","article-title":"Molecular mechanisms of hypertension: Role of Nox family NADPH oxidases","volume":"18","author":"Sedeek","year":"2009","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1161\/CIRCRESAHA.121.318063","article-title":"Oxidative Stress and Hypertension","volume":"128","author":"Griendling","year":"2021","journal-title":"Circ. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/1573403X12666161014094738","article-title":"Endoplasmic reticulum stress in arterial smooth muscle cells: A novel regulator of vascular disease","volume":"13","author":"Shanahan","year":"2017","journal-title":"Curr. Cardiol. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mam.2018.03.002","article-title":"ROS signaling and ER stress in cardiovascular disease","volume":"63","author":"Ochoa","year":"2018","journal-title":"Mol. Asp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"200","DOI":"10.5483\/BMBRep.2015.48.4.274","article-title":"Antioxidant enzymes as redox-based biomarkers: A brief review","volume":"48","author":"Yang","year":"2015","journal-title":"BMB Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cjca.2015.02.008","article-title":"Oxidative stress and human hypertension: Vascular mechanisms, biomarkers, and novel therapies","volume":"31","author":"Montezano","year":"2015","journal-title":"Can. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1253\/jcj.56.170","article-title":"Endothelium-derived hyperpolarizing factor (EDHF)","volume":"56","author":"Suzuki","year":"1992","journal-title":"Jpn. Circ. J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/hr.2013.97","article-title":"Endothelium-derived hyperpolarizing factor and hypertension","volume":"36","author":"Oyama","year":"2013","journal-title":"Hypertens. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1046\/j.1440-1681.1999.03011.x","article-title":"Endothelin-1 as a mediator in cardiovascular disease","volume":"26","author":"Kelly","year":"1999","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Kostov, K. (2021). The causal relationship between endothelin-1 and hypertension: Focusing on endothelial dysfunction, arterial stiffness, vascular remodeling, and blood pressure regulation. Life, 11.","DOI":"10.3390\/life11090986"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0022-2828(90)91041-5","article-title":"Myosin light chain and caldesmon phosphorylation in arterial muscle stimulated with endothelin-1","volume":"22","author":"Adam","year":"1990","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1002\/jcb.22895","article-title":"Mitogen-activated protein kinase in endothelin-1-induced cardiac differentiation of mouse embryonic stem cells","volume":"111","author":"Chen","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.atherosclerosis.2019.09.020","article-title":"Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques","volume":"292","author":"Rafnsson","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1124\/pr.115.011833","article-title":"Endothelin","volume":"68","author":"Davenport","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/01.CIR.83.2.469","article-title":"Endothelin-1-induced vasoconstriction in humans. Reversal by calcium channel blockade but not by nitrovasodilators or endothelium-derived relaxing factor","volume":"83","author":"Kiowski","year":"1991","journal-title":"Circulation"},{"key":"ref_34","first-page":"157","article-title":"The role of endothelin-1 in human hypertension","volume":"37","author":"Shreenivas","year":"2007","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"83S","DOI":"10.1016\/S0895-7061(01)02074-X","article-title":"Role of endothelin-1 in hypertension and vascular disease","volume":"14","author":"Schiffrin","year":"2001","journal-title":"Am. J. Hypertens."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1161\/HYPERTENSIONAHA.111.187021","article-title":"Vascular remodeling in hypertension: Mechanisms and treatment","volume":"59","author":"Schiffrin","year":"2012","journal-title":"Hypertension"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/eurheartj\/14.suppl_C.2","article-title":"Vascular remodelling in hypertension","volume":"14","author":"Mulvany","year":"1993","journal-title":"Eur. Hear. J."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1097\/HJH.0000000000001324","article-title":"Vascular smooth muscle cell peroxisome proliferator-activated receptor gamma protects against endothelin-1-induced oxidative stress and inflammation","volume":"35","author":"Ouerd","year":"2017","journal-title":"J. Hypertens."},{"key":"ref_39","first-page":"R57","article-title":"Development of angiotensin-converting enzyme in fetal rat lungs","volume":"236","author":"Wallace","year":"1979","journal-title":"Am. J. Physiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cca.2021.10.029","article-title":"Angiotensin converting enzyme (ACE)","volume":"524","author":"Khurana","year":"2022","journal-title":"Clin. Chim. Acta"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"45S","DOI":"10.1016\/S0895-7061(99)00248-4","article-title":"Renal responses to AT1 receptor blockade","volume":"13","author":"Navar","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0167-0115(98)00140-2","article-title":"Regulation of angiotensin II type 1 (AT1) receptor function","volume":"79","author":"Thomas","year":"1999","journal-title":"Regul. Pept."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s003950050240","article-title":"Interaction between insulin and AT1 receptor. Relevance for hypertension and arteriosclerosis","volume":"93","author":"Nickenig","year":"1998","journal-title":"Basic Res. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00041552-200501000-00011","article-title":"Update on the role of the AT2 receptor","volume":"14","author":"Carey","year":"2005","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"62S","DOI":"10.1016\/S0895-7061(00)00274-0","article-title":"The role of the AT2 receptor in hypertension","volume":"13","author":"Siragy","year":"2000","journal-title":"Am. J. Hypertens."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Scialo, F., Vitale, M., Daniele, A., Nigro, E., Perrotta, F., Gelzo, M., Iadevaia, C., Cerqua, F.S., Costigliola, A., and Allocca, V. (2021). SARS-CoV-2: One year in the pandemic. What have we learned, the new vaccine era and the threat of SARS-CoV-2 variants. Biomedicines, 9.","DOI":"10.3390\/biomedicines9060611"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00408-020-00408-4","article-title":"ACE2: The major cell entry receptor for SARS-CoV-2","volume":"198","author":"Scialo","year":"2020","journal-title":"Lung"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"105996","DOI":"10.1016\/j.rmed.2020.105996","article-title":"Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?","volume":"168","author":"Perrotta","year":"2020","journal-title":"Respir. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"Raposo","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: Exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J. Cell Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cell.2019.02.029","article-title":"Reassessment of exosome composition","volume":"177","author":"Jeppesen","year":"2019","journal-title":"Cell"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/978-3-030-67171-6_4","article-title":"Apoptotic bodies: Mechanism of formation, isolation and functional relevance","volume":"97","author":"Santavanond","year":"2021","journal-title":"Subcell. Biochem."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Mathiesen, A., Hamilton, T., Carter, N., Brown, M., McPheat, W., and Dobrian, A. (2021). Endothelial extracellular vesicles: From keepers of health to messengers of disease. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22094640"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1177\/1535370220974600","article-title":"Importance of extracellular vesicles in hypertension","volume":"246","author":"Liu","year":"2021","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/HYPERTENSIONAHA.119.13363","article-title":"Circulating extracellular vesicles in normotension restrain vasodilation in resistance arteries","volume":"75","author":"Good","year":"2020","journal-title":"Hypertension"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.bbrc.2018.06.075","article-title":"Plasma exosomes regulate systemic blood pressure in rats","volume":"503","author":"Otani","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.dib.2018.04.149","article-title":"Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary artery disease","volume":"19","author":"Sansone","year":"2018","journal-title":"Data Br."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1080\/23744235.2016.1201721","article-title":"Weight and prognosis for influenza A(H1N1)pdm09 infection during the pandemic period between 2009 and 2011: A systematic review of observational studies with meta-analysis","volume":"48","author":"Sun","year":"2016","journal-title":"Infect. Dis. (Lond)"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/HYPERTENSIONAHA.120.16598","article-title":"Urinary- and plasma-derived exosomes reveal a distinct MicroRNA signature associated with albuminuria in hypertension","volume":"77","author":"Ortega","year":"2021","journal-title":"Hypertension"},{"key":"ref_60","first-page":"494","article-title":"Bioinspired therapeutic platform based on extracellular vesicles for prevention of arterial wall remodeling in hypertension","volume":"8","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.tins.2020.11.003","article-title":"A vessel for change: Endothelial dysfunction in cerebral small vessel disease","volume":"44","author":"Quick","year":"2021","journal-title":"Trends Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e011104","DOI":"10.1161\/JAHA.118.011104","article-title":"Small-Vessel disease in the heart and brain: Current knowledge, unmet therapeutic need, and future directions","volume":"8","author":"Berry","year":"2019","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1093\/eurheartj\/ehaa191","article-title":"Hypertensive coronary microvascular dysfunction: A subclinical marker of end organ damage and heart failure","volume":"41","author":"Zhou","year":"2020","journal-title":"Eur Hear. J."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e021066","DOI":"10.1161\/JAHA.121.021066","article-title":"Impact of peripheral microvascular endothelial dysfunction on white matter hyperintensity","volume":"10","author":"Toya","year":"2021","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e015703","DOI":"10.1161\/JAHA.119.015703","article-title":"Incremental prognostic impact of peripheral microvascular endothelial dysfunction on the development of ischemic stroke","volume":"9","author":"Toya","year":"2020","journal-title":"J. Am. Hear. Assoc."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/hr.2015.4","article-title":"Endothelial dysfunction is associated with the severity of cerebral small vessel disease","volume":"38","author":"Nezu","year":"2015","journal-title":"Hypertens. Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/HYPERTENSIONAHA.107.089680","article-title":"Microvascular dysfunction: A potential pathophysiological role in the metabolic syndrome","volume":"50","author":"Serne","year":"2007","journal-title":"Hypertension"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/HYPERTENSIONAHA.109.148957","article-title":"Endothelial dysfunction and hypertension: Cause or effect?","volume":"55","author":"Quyyumi","year":"2010","journal-title":"Hypertension"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1161\/01.CIR.101.16.1899","article-title":"Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease","volume":"101","author":"Schachinger","year":"2000","journal-title":"Circulation"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1161\/CIRCULATIONAHA.109.864801","article-title":"Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: The multi-ethnic study of atherosclerosis","volume":"120","author":"Yeboah","year":"2009","journal-title":"Circulation"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1161\/01.CIR.0000012543.55874.47","article-title":"Risk stratification for postoperative cardiovascular events via noninvasive assessment of endothelial function: A prospective study","volume":"105","author":"Gokce","year":"2002","journal-title":"Circulation"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1161\/HYPERTENSIONAHA.109.143123","article-title":"Endothelial dysfunction and the risk of hypertension: The multi-ethnic study of atherosclerosis","volume":"55","author":"Shimbo","year":"2010","journal-title":"Hypertension"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/eurheartj\/ehi112","article-title":"Interaction between vascular dysfunction and cardiac mass increases the risk of cardiovascular outcomes in essential hypertension","volume":"26","author":"Sciacqua","year":"2005","journal-title":"Eur. Hear. J."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1161\/HYPERTENSIONAHA.120.15761","article-title":"Association of cardiovascular risk factors and lifestyle behaviors with hypertension: A mendelian randomization study","volume":"76","author":"Beulens","year":"2020","journal-title":"Hypertension"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1161\/01.HYP.33.4.937","article-title":"A large blood pressure-raising effect of nitric oxide synthase inhibition in humans","volume":"33","author":"Sander","year":"1999","journal-title":"Hypertension"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.HYP.0000237666.78217.47","article-title":"Elevated blood pressure in adolescent boys predicts endothelial dysfunction: The cardiovascular risk in young Finns study","volume":"48","author":"Juonala","year":"2006","journal-title":"Hypertension"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.jacc.2004.07.027","article-title":"Flow-mediated vasodilation and the risk of developing hypertension in healthy postmenopausal women","volume":"44","author":"Rossi","year":"2004","journal-title":"J. Am. Coll. Cardiol"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cca.2015.05.013","article-title":"Glycocalyx injury in adults with nephrotic syndrome: Association with endothelial function","volume":"447","author":"Salmito","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1582-4934.2008.00639.x","article-title":"Circulating endothelial cells, microparticles and progenitors: Key players towards the definition of vascular competence","volume":"13","author":"Sabatier","year":"2009","journal-title":"J. Cell Mol. Med."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000322853","article-title":"Assessment of lower limb microcirculation: Exploring the reproducibility and clinical application of laser Doppler techniques","volume":"24","author":"Klonizakis","year":"2011","journal-title":"Ski. Pharm. Physiol"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/eurheartj\/ehq010","article-title":"Assessment of endothelial function by non-invasive peripheral arterial tonometry predicts late cardiovascular adverse events","volume":"31","author":"Rubinshtein","year":"2010","journal-title":"Eur. Hear. J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1161\/CIRCULATIONAHA.112.093245","article-title":"The assessment of endothelial function: From research into clinical practice","volume":"126","author":"Flammer","year":"2012","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"Corretti","year":"2002","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1161\/HYPERTENSIONAHA.120.15754","article-title":"Reference intervals for brachial artery flow-mediated dilation and the relation with cardiovascular risk factors","volume":"77","author":"Holder","year":"2021","journal-title":"Hypertension"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.atherosclerosis.2016.03.011","article-title":"Adherence to guidelines strongly improves reproducibility of brachial artery flow-mediated dilation","volume":"248","author":"Greyling","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1111\/bph.13517","article-title":"Targeting vascular (endothelial) dysfunction","volume":"174","author":"Daiber","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.atherosclerosis.2020.10.014","article-title":"Endothelial dysfunction in COVID-19: Current findings and therapeutic implications","volume":"314","author":"Nagele","year":"2020","journal-title":"Atherosclerosis"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"580419","DOI":"10.3389\/fcvm.2020.580419","article-title":"Effects of oral drugs on coronary microvascular function in patients without significant stenosis of epicardial coronary arteries: A systematic review and meta-analysis of coronary flow reserve","volume":"7","author":"Yong","year":"2020","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1016\/j.jacc.2019.03.507","article-title":"ACC\/AHA versus ESC\/ESH on hypertension guidelines: JACC guideline comparison","volume":"73","author":"Bakris","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_90","first-page":"336","article-title":"Cardioprotection by angiotensin-converting enzyme (ACE) inhibitors","volume":"9","author":"Juggi","year":"1993","journal-title":"Can. J. Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1161\/01.CIR.99.6.817","article-title":"Cardioprotective effect of angiotensin-converting enzyme inhibition against hypoxia\/reoxygenation injury in cultured rat cardiac myocytes","volume":"99","author":"Matoba","year":"1999","journal-title":"Circulation"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.atherosclerosis.2011.02.044","article-title":"Angiotensin converting enzyme inhibitors effect on endothelial dysfunction: A meta-analysis of randomised controlled trials","volume":"216","author":"Shahin","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/01.RES.86.2.139","article-title":"Angiotensin-converting enzyme inhibitors downregulate tissue factor synthesis in monocytes","volume":"86","author":"Napoleone","year":"2000","journal-title":"Circ. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2174\/157016112798829751","article-title":"Therapeutic strategies targeting endothelial function in humans: Clinical implications","volume":"10","author":"Lee","year":"2012","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1161\/HYPERTENSIONAHA.109.144600","article-title":"Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function","volume":"55","author":"Erdos","year":"2010","journal-title":"Hypertension"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1024\/0301-1526\/a000971","article-title":"Effect of ACEI and ARB treatment on nitric oxide-dependent endothelial function","volume":"50","author":"Li","year":"2021","journal-title":"Vasa"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.2174\/0929867325666180713144806","article-title":"Calcium channel blockers in restoration of endothelial function: Systematic review and meta-analysis of randomized controlled trials","volume":"26","author":"Radenkovic","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/01.CIR.94.3.258","article-title":"Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (trial on reversing endothelial dysfunction) study","volume":"94","author":"Mancini","year":"1996","journal-title":"Circulation"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1161\/HYPERTENSIONAHA.120.15721","article-title":"Vascular effects of ACE (angiotensin-converting enzyme) inhibitors and statins in adolescents with type 1 diabetes","volume":"76","author":"Chiesa","year":"2020","journal-title":"Hypertension"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.2337\/dc06-1551","article-title":"Impact of telmisartan versus ramipril on renal endothelial function in patients with hypertension and type 2 diabetes","volume":"30","author":"Schmieder","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: The JNC 7 report","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1524-6175.2006.05690.x","article-title":"A randomized, double-blind trial comparing the effects of amlodipine besylate\/benazepril HCl vs amlodipine on endothelial function and blood pressure","volume":"8","author":"Mohler","year":"2006","journal-title":"J. Clin. Hypertens. (Greenwich)"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1161\/01.CIR.93.7.1380","article-title":"Normalization of abnormal coronary vasomotion by calcium antagonists in patients with hypertension","volume":"93","author":"Frielingsdorf","year":"1996","journal-title":"Circulation"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1042\/CS20120311","article-title":"Dihydropyridine calcium channel blockers inhibit non-esterified-fatty-acid-induced endothelial and rheological dysfunction","volume":"125","author":"Yasu","year":"2013","journal-title":"Clin. Sci."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1161\/01.STR.30.9.1907","article-title":"1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats","volume":"30","author":"Napoli","year":"1999","journal-title":"Stroke"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1097\/00005344-199800002-00002","article-title":"Combination of ACE inhibitors and calcium antagonists: A logical approach","volume":"31","author":"Ruschitzka","year":"1998","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3109\/10641963.2011.577491","article-title":"Effects of lisinopril, irbesartan, and amlodipine on the thrombogenic variables in the early and late stages of the treatment in hypertensive patients","volume":"34","author":"Tiryaki","year":"2012","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_108","first-page":"CD002003","article-title":"Beta-blockers for hypertension","volume":"2017","author":"Wiysonge","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_109","first-page":"65","article-title":"Pharmacotherapy for coronary microvascular dysfunction","volume":"1","author":"Ong","year":"2015","journal-title":"Eur. Hear. J.-Cardiovasc. Pharm."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"4568","DOI":"10.1016\/j.bmc.2006.02.023","article-title":"Antioxidant activity of beta-blockers: An effect mediated by scavenging reactive oxygen and nitrogen species?","volume":"14","author":"Gomes","year":"2006","journal-title":"Bioorganic Med. Chem."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11906-007-0050-2","article-title":"The vasodilatory beta-blockers","volume":"9","author":"Pedersen","year":"2007","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1161\/01.CIR.0000066912.58385.DE","article-title":"Third-generation beta-blockers stimulate nitric oxide release from endothelial cells through ATP efflux: A novel mechanism for antihypertensive action","volume":"107","author":"Kalinowski","year":"2003","journal-title":"Circulation"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1742-7843.2012.00911.x","article-title":"Effect of carvedilol and nebivolol on oxidative stress-related parameters and endothelial function in patients with essential hypertension","volume":"111","author":"Zepeda","year":"2012","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S0140-6736(05)66378-7","article-title":"The metabolic syndrome","volume":"365","author":"Eckel","year":"2005","journal-title":"Lancet"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCULATIONAHA.110.985150","article-title":"Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling","volume":"124","author":"Antoniades","year":"2011","journal-title":"Circulation"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pharmthera.2018.10.004","article-title":"Statins: Adverse reactions, oxidative stress and metabolic interactions","volume":"195","author":"Liu","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/07853890.2013.874661","article-title":"Lipid profile changes in patients with rheumatic diseases receiving a treatment with TNF-alpha blockers: A meta-analysis of prospective studies","volume":"46","author":"Ambrosino","year":"2014","journal-title":"Ann. Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.2174\/138161207780831220","article-title":"Influence of statin use on endothelial function: From bench to clinics","volume":"13","author":"Badimon","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijcard.2012.04.054","article-title":"Low-density lipoprotein-independent improvement of flow-mediated dilatation with atorvastatin: A meta-analysis and meta-regression of randomized controlled trials","volume":"158","author":"Takagi","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"ref_120","doi-asserted-by":"crossref","unstructured":"Zinellu, A., and Mangoni, A.A. (2021). Systematic review and meta-analysis of the effect of statins on circulating E-selectin, L-selectin, and P-selectin. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111707"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.niox.2022.01.001","article-title":"An updated systematic review and meta-analysis of the effect of statins on asymmetric dimethylarginine","volume":"120","author":"Zinellu","year":"2022","journal-title":"Nitric Oxide"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Maruhashi, T., and Higashi, Y. (2021). Pathophysiological association between diabetes mellitus and endothelial dysfunction. Antioxidants, 10.","DOI":"10.3390\/antiox10081306"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00228-015-1999-4","article-title":"Thiazolidinediones improve flow-mediated dilation: A meta-analysis of randomized clinical trials","volume":"72","author":"Stojanovic","year":"2016","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.2169\/internalmedicine.0701-17","article-title":"The SGLT2 inhibitor dapagliflozin significantly improves the peripheral microvascular endothelial function in patients with uncontrolled type 2 diabetes mellitus","volume":"57","author":"Sugiyama","year":"2018","journal-title":"Intern. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pharmthera.2018.07.007","article-title":"Endothelial function and dysfunction: Impact of metformin","volume":"192","author":"Nafisa","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.2174\/1381612822666160603020003","article-title":"The impact of antiplatelet treatment on endothelial function","volume":"22","author":"Androulakis","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Lee, S.J., Lee, J.S., Choi, M.H., Lee, S.E., Shin, D.H., and Hong, J.M. (2017). Cilostazol improves endothelial function in acute cerebral ischemia patients: A double-blind placebo controlled trial with flow-mediated dilation technique. BMC Neurol., 17.","DOI":"10.1186\/s12883-017-0950-y"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.3892\/mmr.2016.4881","article-title":"Cilostazol suppresses angiotensin II-induced apoptosis in endothelial cells","volume":"13","author":"Shi","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/0003319715606249","article-title":"Cilostazol enhances mobilization of circulating endothelial progenitor cells and improves endothelium-dependent function in patients at high risk of cardiovascular disease","volume":"67","author":"Chao","year":"2016","journal-title":"Angiology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ajh.2008.6","article-title":"Cilostazol activates AMP-activated protein kinase and restores endothelial function in diabetes","volume":"21","author":"Suzuki","year":"2008","journal-title":"Am. J. Hypertens."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11906-001-0081-z","article-title":"Antioxidants and endothelial dysfunction in hyperlipidemia","volume":"3","author":"Warnholtz","year":"2001","journal-title":"Curr. Hypertens. Rep."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1517\/14728220802517901","article-title":"N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility","volume":"8","author":"Dodd","year":"2008","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/aps.2016.12","article-title":"N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys","volume":"37","author":"Shen","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"ref_134","first-page":"R767","article-title":"N-acetyl-L-cysteine potentiates depressor response to captopril and enalaprilat in SHRs","volume":"267","author":"Ruiz","year":"1994","journal-title":"Am. J. Physiol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3892\/mmr.2021.11840","article-title":"Nacetylcysteine inhibits atherosclerosis by correcting glutathionedependent methylglyoxal elimination and dicarbonyl\/oxidative stress in the aorta of diabetic mice","volume":"23","author":"Fang","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1159\/000106103","article-title":"Effect of N-acetylcysteine on endothelial dysfunction in dialysis patients","volume":"25","author":"Sahin","year":"2007","journal-title":"Blood Purif."},{"key":"ref_137","first-page":"503","article-title":"N-acetylcysteine neither lowers plasma homocysteine concentrations nor improves brachial artery endothelial function in cardiac transplant recipients","volume":"18","author":"Miner","year":"2002","journal-title":"Can. J. Cardiol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Kim, D.H., Meza, C.A., Clarke, H., Kim, J.S., and Hickner, R.C. (2020). Vitamin D and endothelial function. Nutrients, 12.","DOI":"10.3390\/nu12020575"},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Chiu, H.F., Venkatakrishnan, K., Golovinskaia, O., and Wang, C.K. (2021). Impact of micronutrients on hypertension: Evidence from clinical trials with a special focus on meta-analysis. Nutrients, 13.","DOI":"10.3390\/nu13020588"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"4940673","DOI":"10.1155\/2020\/4940673","article-title":"Association between serum vitamin C and the blood pressure: A systematic review and meta-analysis of observational studies","volume":"2020","author":"Ran","year":"2020","journal-title":"Cardiovasc. Ther."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"e19274","DOI":"10.1097\/MD.0000000000019274","article-title":"Effects of vitamin C supplementation on essential hypertension: A systematic review and meta-analysis","volume":"99","author":"Guan","year":"2020","journal-title":"Medicine (Baltimore)"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ejheart.2005.03.007","article-title":"Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure","volume":"7","author":"Tousoulis","year":"2005","journal-title":"Eur. J. Hear. Fail."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41371-019-0192-0","article-title":"Effect of vitamin E supplementation on blood pressure: A systematic review and meta-analysis","volume":"33","author":"Emami","year":"2019","journal-title":"J. Hum. Hypertens."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1152\/japplphysiol.00660.2006","article-title":"Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression","volume":"102","author":"Gates","year":"2007","journal-title":"J. Appl. Physiol."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Shiraseb, F., Asbaghi, O., Bagheri, R., Wong, A., Figueroa, A., and Mirzaei, K. (2021). The effect of L-arginine supplementation on blood pressure in adults: A systematic review and dose-response meta-analysis of randomized clinical trials. Adv. Nutr. Int. Rev. J.","DOI":"10.1093\/advances\/nmab155"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1097\/PHM.0b013e3181570b74","article-title":"Rehabilitation effectiveness: The state of the science and a hope for the future","volume":"86","author":"Whyte","year":"2007","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1080\/14779072.2019.1651198","article-title":"Exercise training and cardiac rehabilitation in cardiovascular disease","volume":"17","author":"Kachur","year":"2019","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/berh.2000.0111","article-title":"Physical therapy and rehabilitation in the management of rheumatic disorders","volume":"14","author":"Stucki","year":"2000","journal-title":"Best Pr. Res. Clin. Rheumatol."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/crj.12507","article-title":"The effect of pulmonary rehabilitation on COPD exacerbation frequency per year","volume":"12","author":"Sahin","year":"2018","journal-title":"Clin. Respir. J."},{"key":"ref_150","first-page":"CD003793","article-title":"Pulmonary rehabilitation for chronic obstructive pulmonary disease","volume":"2","author":"McCarthy","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_151","first-page":"CD001800","article-title":"Exercise-based cardiac rehabilitation for coronary heart disease","volume":"1","author":"Anderson","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Heran, B.S., Chen, J.M., Ebrahim, S., Moxham, T., Oldridge, N., Rees, K., Thompson, D.R., and Taylor, R.S. (2011). Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst. Rev., CD001800.","DOI":"10.1002\/14651858.CD001800.pub2"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1161\/STROKEAHA.119.024150","article-title":"New treatment approaches to modify the course of cerebral small vessel diseases","volume":"51","author":"Smith","year":"2020","journal-title":"Stroke"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"e14145","DOI":"10.14814\/phy2.14145","article-title":"Effects of a rehabilitation program on microvascular function of CHD patients assessed by near-infrared spectroscopy","volume":"7","author":"Soares","year":"2019","journal-title":"Physiol. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0002-9149(99)00233-7","article-title":"Influence of age and gender on exercise training-induced blood pressure reduction in systemic hypertension","volume":"84","author":"Ishikawa","year":"1999","journal-title":"Am. J. Cardiol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1152\/jappl.1986.61.2.673","article-title":"Enhanced maximal metabolic vasodilatation in the dominant forearms of tennis players","volume":"61","author":"Sinoway","year":"1986","journal-title":"J. Appl. Physiol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1177\/2047487319878958","article-title":"Systematic review of cardiac rehabilitation guidelines: Quality and scope","volume":"27","author":"Mehra","year":"2020","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00380-018-1128-2","article-title":"Heart failure with preserved vs reduced ejection fraction following cardiac rehabilitation: Impact of endothelial function","volume":"33","author":"Tanaka","year":"2018","journal-title":"Hear. Vessel."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1177\/2047487314565739","article-title":"Cardiac rehabilitation improves coronary endothelial function in patients with heart failure due to dilated cardiomyopathy: A positron emission tomography study","volume":"23","author":"Legallois","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.ijcard.2012.04.157","article-title":"Impact of a cardiac rehabilitation program and inflammatory state on endothelial progenitor cells in acute coronary syndrome patients","volume":"167","author":"Cesari","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.hlc.2016.06.1210","article-title":"The beneficial effects of cardiac rehabilitation on the function and levels of endothelial progenitor cells","volume":"26","author":"Guo","year":"2017","journal-title":"Hear. Lung Circ."},{"key":"ref_162","doi-asserted-by":"crossref","unstructured":"Merlo, C., Bernardi, E., Bellotti, F., Pomidori, L., and Cogo, A. (2020). Supervised exercise training improves endothelial function in COPD patients: A method to reduce cardiovascular risk?. ERJ Open Res., 6.","DOI":"10.1183\/23120541.00304-2019"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"3583956","DOI":"10.1155\/2016\/3583956","article-title":"Vascular ageing and exercise: Focus on cellular reparative processes","volume":"2016","author":"Ross","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJMra1805377","article-title":"Treating hypertension in chronic obstructive pulmonary disease","volume":"382","author":"Finks","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.hfc.2019.06.007","article-title":"Hypertension and Heart Failure","volume":"15","author":"Slivnick","year":"2019","journal-title":"Hear. Fail. Clin."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Ambrosino, P., Molino, A., Calcaterra, I., Formisano, R., Stufano, S., Spedicato, G.A., Motta, A., Papa, A., Di Minno, M.N.D., and Maniscalco, M. (2021). Clinical assessment of endothelial function in convalescent COVID-19 patients undergoing multidisciplinary pulmonary rehabilitation. 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