{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T16:04:43Z","timestamp":1769011483929,"version":"3.49.0"},"reference-count":25,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Biosense Webster","award":["No. HCO00004"],"award-info":[{"award-number":["No. HCO00004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>This randomized study aims to compare the left atrial (LA) lesion size, function, and tissue damage following pulmonary vein isolation (PVI) by high-power short-duration (HPSD) radiofrequency (RF) and second-generation cryoballoon (CB2) ablation. We enrolled 40 patients with paroxysmal atrial fibrillation who underwent PVI by HPSD RF (n = 21) or CB2 (n = 19). Every patient underwent LA CT angiography and transthoracic echocardiography (TTE) to assess the LA anatomy and function. Biomarker levels (hs-cTnT, hs-CRP, LDH) were compared pre- and post-procedurally. Pre- and post-ablation high-density mapping (HDM) was performed. The isolation area was defined under 0.2 mV bipolar voltage (low voltage area, LVA). We calculated the post-PVI LVA\/LA surface ratio using LA CT-HDM merge images. At 3-month follow-up, TTE was performed to assess the changes in LA function. Post-ablation hs-cTnT level was significantly higher in the RF group (RF: 1249 \u00b1 469 ng\/L, CB2: 995 \u00b1 280 ng\/L, p = 0.024). Post-PVI hs-CRP (RF: 9.53 \u00b1 10.30 mg\/L, CB2: 12.36 \u00b1 5.76 mg\/L, p = 0.034) and LDH levels (RF: 349.9 \u00b1 65.6 U\/L, CB2: 451.6 \u00b1 91.3 U\/L, p &lt; 0.001) were significantly higher following CB2 ablation. Post-PVI LVA\/LA surface ratios were 8.37 \u00b1 6.42% in the RF group and 13.58 \u00b1 8.92% in the CB2 group (p = 0.022). LA function did not change significantly after the PVI procedure. Our data indicate that second-generation cryoballoon ablation produces a significantly larger LA lesion size compared to \u201cpoint-by-point\u201d HPSD radiofrequency. Both techniques preserve LA function. The myocardial component of tissue loss appears to be higher using HPSD radiofrequency ablation, with less collateral damage.<\/jats:p>","DOI":"10.3390\/jcdd9100327","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"327","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Isolation Area, Myocardial Injury and Left Atrial Function Following High-Power Short-Duration Radiofrequency or Second-Generation Cryoballoon Ablation for Atrial Fibrillation"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9175-4219","authenticated-orcid":false,"given":"Krisztian Istvan","family":"Kassa","sequence":"first","affiliation":[{"name":"Karoly Racz Doctoral School of Clinical Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsofia","family":"Nagy","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Simkovits","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsuzsanna","family":"Kis","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamas","family":"Ferenci","sequence":"additional","affiliation":[{"name":"Physiological Controls Research Center, Obuda University, 1034 Budapest, Hungary"},{"name":"Department of Statistics, Corvinus University of Budapest, 1093 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoltan","family":"Som","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Csaba","family":"Foldesi","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"Kardos","sequence":"additional","affiliation":[{"name":"Gottsegen National Cardiovascular Center, 1096 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/eurheartj\/ehaa612","article-title":"2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS)","volume":"42","author":"Hindricks","year":"2020","journal-title":"Eur. 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