{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:07:53Z","timestamp":1789693673135,"version":"4.0.1"},"reference-count":8,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T00:00:00Z","timestamp":1669248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Minnesota\u2019s Institute for Engineering in Medicine"},{"name":"Medtronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Transcatheter aortic valve replacement (TAVR) has become a popular treatment option for severe aortic stenosis for patients with a high risk for mortality with surgical aortic valve replacement (SAVR). Coronary artery occlusion (CAO) following the implantation of the device is a potential and sometimes devastating complication of this procedure, that provokes a sudden deterioration of hemodynamic status followed by cardiogenic shock and electrical instability. With patients that present a high risk for coronary obstruction, coronary protection with a chimney stenting technique is an effective strategy that can ensure coronary perfusion during TAVR in case of acute CAO. Utilizing Visible Heart\u00ae methodologies, a human heart was reanimated. A chimney stenting technique was implemented simultaneously with the deployment of a Medtronic Evolut\u2122 Pro+ valve (Medtronic PLC; Minneapolis, MN, USA). The entire procedure was recorded utilizing endoscopic cameras, fluoroscopy, optical coherence tomography, and echocardiography. In addition to these procedural visualizations, post-procedural micro-computed tomography (micro-CT) was conducted to provide post-implantation imaging with approximately 60-micron resolution. Utilizing these imaging modalities in a reanimated human heart allows for the unique opportunity to collect data for TAVR procedures in real human anatomies for the subsequent educational uses by the physicians treating aortic valvular disease and\/or the designers of future TAVR technologies and procedures.<\/jats:p>","DOI":"10.3390\/jcdd9120413","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T02:54:05Z","timestamp":1669258445000},"page":"413","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Multimodal Imaging of a Chimney-Stenting Procedure Performed Simultaneously with a Transcatheter Aortic Valve Replacement (TAVR) in a Reanimated Human Heart including Post-Implant Analyses"],"prefix":"10.3390","volume":"9","author":[{"given":"Michael A.","family":"Bielecki","sequence":"first","affiliation":[{"name":"Departments of Surgery and Biomedical Engineering, Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda N.","family":"DeVos","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Biomedical Engineering, Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-6462","authenticated-orcid":false,"given":"Francesco","family":"Bianchini","sequence":"additional","affiliation":[{"name":"Cardiology, Fondazione Policlinico Universitario Agostino Gemelli, 00168 Metropolitan City of Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Iaizzo","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Biomedical Engineering, Institute for Engineering in Medicine, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,24]]},"reference":[{"key":"ref_1","first-page":"e25","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s12265-014-9561-9","article-title":"Advances in transcatheter valve therapies","volume":"7","author":"Steinberg","year":"2014","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.jacc.2020.09.595","article-title":"STS-ACC TVT Registry of Transcatheter Aortic Valve Replacement","volume":"76","author":"Carroll","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.carrev.2020.12.013","article-title":"An \u201cOrthotopic\u201d Snorkel-Stenting Technique to Maintain Coronary Patency During Transcatheter Aortic Valve Replacement","volume":"28","author":"Burzotta","year":"2021","journal-title":"Cardiovasc. Revascularization Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e09","DOI":"10.15420\/icr.2020.08","article-title":"Chimney Stenting During Transcatheter Aortic Valve Implantation","volume":"15","author":"Rosseel","year":"2020","journal-title":"Interv. Cardiol."},{"key":"ref_6","first-page":"163","article-title":"The Visible Heart\u00ae project and free-access website \u201cAtlas of Human Cardiac Anatomy\u201d","volume":"18","author":"Iaizzo","year":"2016","journal-title":"EP Eur."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/S0003-4975(00)01977-9","article-title":"Isolated four-chamber working swine heart model","volume":"70","author":"Chinchoy","year":"2000","journal-title":"Ann. Thorac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhingre Sanchez, J.D., Schinstock, E.A., Bateman, M.G., and Iaizzo, P.A. (2019, January 15\u201318). The development and testing of a fixation apparatus for inducing the coaptation of the cardiac atrioventricular valves. Proceedings of the 2019 Design of Medical Devices Conference, Minneapolis, MN, USA.","DOI":"10.1115\/DMD2019-3298"}],"container-title":["Journal of Cardiovascular Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2308-3425\/9\/12\/413\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:37Z","timestamp":1760145937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2308-3425\/9\/12\/413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,24]]},"references-count":8,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["jcdd9120413"],"URL":"https:\/\/doi.org\/10.3390\/jcdd9120413","relation":{},"ISSN":["2308-3425"],"issn-type":[{"value":"2308-3425","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,24]]}}}