{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:27:06Z","timestamp":1791642426237,"version":"4.3.4"},"reference-count":32,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Government of Ireland","award":["DT20180123"],"award-info":[{"award-number":["DT20180123"]}]},{"name":"Government of Ireland","award":["RTI2018-094357-B-C21"],"award-info":[{"award-number":["RTI2018-094357-B-C21"]}]},{"name":"Spanish MCIN\/AEI\/10.13039\/501100011033","award":["DT20180123"],"award-info":[{"award-number":["DT20180123"]}]},{"name":"Spanish MCIN\/AEI\/10.13039\/501100011033","award":["RTI2018-094357-B-C21"],"award-info":[{"award-number":["RTI2018-094357-B-C21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCDD"],"abstract":"<jats:p>Background: Pulsed Electric Field (PEF) ablation has been recently proposed to ablate cardiac ganglionic plexi (GP) aimed to treat atrial fibrillation. The effect of metal intracoronary stents in the vicinity of the ablation electrode has not been yet assessed. Methods: A 2D numerical model was developed accounting for the different tissues involved in PEF ablation with an irrigated ablation device. A coronary artery (with and without a metal intracoronary stent) was considered near the ablation source (0.25 and 1 mm separation). The 1000 V\/cm threshold was used to estimate the \u2018PEF-zone\u2019. Results: The presence of the coronary artery (with or without stent) distorts the E-field distribution, creating hot spots (higher E-field values) in the front and rear of the artery, and cold spots (lower E-field values) on the sides of the artery. The value of the E-field inside the coronary artery is very low (~200 V\/cm), and almost zero with a metal stent. Despite this distortion, the PEF-zone contour is almost identical with and without artery\/stent, remaining almost completely confined within the fat layer in any case. The mentioned hot spots of E-field translate into a moderate temperature increase (&lt;48 \u00b0C) in the area between the artery and electrode. These thermal side effects are similar for pulse intervals of 10 and 100 \u03bcs. Conclusions: The presence of a metal intracoronary stent near the ablation device during PEF ablation simply \u2018amplifies\u2019 the E-field distortion already caused by the presence of the vessel. This distortion may involve moderate heating (&lt;48 \u00b0C) in the tissue between the artery and ablation electrode without associated thermal damage.<\/jats:p>","DOI":"10.3390\/jcdd9120458","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T02:54:21Z","timestamp":1670986461000},"page":"458","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["In Silico Modelling to Assess the Electrical and Thermal Disturbance Provoked by a Metal Intracoronary Stent during Epicardial Pulsed Electric Field Ablation"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-4176","authenticated-orcid":false,"given":"Ana","family":"Gonz\u00e1lez-Su\u00e1rez","sequence":"first","affiliation":[{"name":"School of Engineering, University of Galway, H91 TK33 Galway, Ireland"},{"name":"Translational Medical Device Lab, University of Galway, H91 YR71 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-8699","authenticated-orcid":false,"given":"Juan J.","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"BioMIT, Department of Electronic Engineering, Universitat Polit\u00e8cnica de Val\u00e8ncia, 46022 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"AtriAN Medical Limited, Unit 204, University of Galway Business Innovation Centre, Upper Newcastle, H91 W60E Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0988-5776","authenticated-orcid":false,"given":"Adnan","family":"Elahi","sequence":"additional","affiliation":[{"name":"School of Engineering, University of Galway, H91 TK33 Galway, Ireland"},{"name":"Translational Medical Device Lab, University of Galway, H91 YR71 Galway, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/jce.13860","article-title":"Electroporation of epicardial autonomic ganglia: Safety and efficacy in medium-term canine models","volume":"30","author":"Padmanabhan","year":"2019","journal-title":"J. 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